The effect of the synthetic retinoid etretinate on sputum cytology: results from a randomised trial

Arnold, Andrew; Browman, George P.; Levine, Mark; D'Souza, T.J.; Johnstone, B.; Skingley, Peter; Turner-Smith, L.; Cayco, R.; Booker, Lynda; Newhouse, Muriel L.

doi:10.1038/bjc.1992.156

Cited by 83 publications

(19 citation statements)

References 19 publications

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“…Because bronchial metaplasia is reversible, it has been used as an intermediate endpoint for several lung cancer prevention trials, some of which have included various retinoids (8)(9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

Dietary vitamin A and prevalence of bronchial metaplasia in asbestos-exposed workers

Mayne¹,

Redlich²,

Cullen³

1998

The American Journal of Clinical Nutrition

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The purpose of this investigation was to examine the association between dietary intake of vitamin A in the form of retinol and provitamin A carotenoids and the prevalence of bronchial squamous metaplasia in a sample of asbestos workers from an industrial clinic. Bronchial biopsies were obtained from 49 asbestos workers. Pulmonary function testing was done and in-person interviews were conducted to estimate dietary intake of retinol and provitamin A carotenoids, tobacco exposure, and asbestos exposure. Results indicated that workers with metaplasia reported consuming a significantly lower intake of total vitamin A [2000 retinol equivalents (RE)/d] than did subjects without metaplasia (2710 RE/d, P = 0.02). Logistic regression analyses showed that higher intakes of retinol [odds ratio (OR): 0.31; 95% CI: 0.04, 2.44], provitamin A carotenoids (OR: 0.31; 95% CI: 0.03, 2.84), and total vitamin A (OR: 0.29; 95% CI: 0.03, 2.49) were associated with a nonsignificant reduction in the OR for metaplasia (highest quartile compared with lowest quartile, adjusted ORs). Current smoking (OR: 5.25; 95% CI: 0.50, 55.1) and former smoking (OR: 2.95; 95% CI: 0.31, 28.1) were associated with a nonsignificant increase in the OR for bronchial metaplasia compared with never smoking. Greater airway obstruction [decreased forced expiratory volume in 1 s (FEV 1 )/forced vital capacity (FVC)] was associated with an increased OR for metaplasia (OR: 2.86; 95% CI: 1.09, 7.69). These results suggest that a higher (ie, above the median) intake of vitamin A from foods decreases the risk of bronchial metaplasia in workers occupationally exposed to asbestos.Am J Clin Nutr 1998;68:630-5.

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Section: Introductionmentioning

confidence: 99%

Dietary vitamin A and prevalence of bronchial metaplasia in asbestos-exposed workers

Mayne¹,

Redlich²,

Cullen³

1998

The American Journal of Clinical Nutrition

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“…All three of the randomized trials of retinoids that have been conducted in smokers with metaplasia have been negative (see Table I). A placebo-controlled trial of 6 months of etretinate to reverse metaplasia in sputum samples [17] found that metaplasia was reversed in 32% of etretinate subjects and 30% of placebo subjects. A placebo-controlled trial of isotretinoin [18] for the reversal of metaplasia in bronchial biopsy specimens found that both study groups experienced a substantial reduction in metaplasia index (54% isotretinoin vs. 60% placebo).…”

Section: Lung Pre-malignancy Trialsmentioning

confidence: 97%

Lung cancer chemoprevention

Khuri

Lippman

2000

Sem. Surg. Onc.

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“…Reversal of these premalignant lesions through various treatment modalities may prevent progression to lung cancer. Studies have included various agents to treat sputum atypia [4][5][6][7] or bronchial squamous metaplasia [8][9][10][11]. One study even showed improvement of bronchial epithelium metaplasia in smokers with administration of folate and vitamin B 12 [12].…”

Section: Reversal Of Premalignant Lesionsmentioning

confidence: 99%

Chemoprevention of lung cancer

Kim

Khuri

2002

Curr Oncol Rep

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Lung cancer is the leading cause of death worldwide. Its overall survival rate has improved only slightly, and surgery, radiotherapy, and chemotherapy remain the mainstays of current treatment. Therapies with novel targeted agents are currently under active investigation in all settings of treatment including chemoprevention, defined as the use of natural or synthetic agents to interrupt the process of carcinogenesis and to prevent or delay tumor occurrence. Thus, chemoprevention describes the collaborative efforts of researchers in basic science and clinical settings who study the biology of lung cancer with the hope of uncovering new mechanisms of treatment. Because lung cancer has become an increasingly difficult problem to treat with standard therapies, chemopreventive strategies have been developed. Small molecule compounds that target specific receptors or mutations will play an increasingly significant role in treatment of lung cancer because the side effect profiles of such agents are tolerable and they may be more effective than other treatments.

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The effect of the synthetic retinoid etretinate on sputum cytology: results from a randomised trial

Abstract: Summary Laboratory studies, and one previous uncontrolled trial, have

Cited by 83 publications

References 19 publications

Dietary vitamin A and prevalence of bronchial metaplasia in asbestos-exposed workers

Dietary vitamin A and prevalence of bronchial metaplasia in asbestos-exposed workers

Lung cancer chemoprevention

Chemoprevention of lung cancer

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