FAILURE OF HIGH RESISTANCE AND SUBMAXIMAL EXERCISE TRAINING TO ALTER SARCOPLASMIC RETICULUM Ca2* ATPase IN HUMAN MUSCLE.

Green, H.; Grange, F.; Goreham, C.; Shoemaker, Kevin; Grant, Susan

doi:10.1249/00005768-199505001-00366

Cited by 5 publications

(2 citation statements)

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“…Before training, the maximal SR Ca 2ϩ uptake of the vastus lateralis of the young women in this study (10.5 nmol • mg Ϫ1 protein • min Ϫ1 ) was similar to that reported in young men (10.4 nmol • mg Ϫ1 protein • min Ϫ1 ) (5). The failure of the SR of skeletal muscle in the young women to adapt to short-term high-resistance training was consistent with a previous study that reported no alteration in SR Ca 2ϩ -ATPase activity in the vastus lateralis of young men after 12-wk high-resistance training (20). It is important to note that the absence of adaptation of SR Ca 2ϩ uptake and SR Ca 2ϩ -ATPase found in young subjects in the latter study and the present one may be specific to the training dosages and duration imposed.…”

Section: Reductions In Sr Ca 2ϩ Uptake and Sr Ca 2ϩ -Atpase Activity supporting

confidence: 91%

Human skeletal sarcoplasmic reticulum Ca²⁺uptake and muscle function with aging and strength training

Hunter¹,

Thompson²,

Ruell³

et al. 1999

Journal of Applied Physiology

126

109

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This study investigated the adaptations of skeletal muscle sarcoplasmic reticulum (SR) Ca2+ uptake, relaxation, and fiber types in young (YW) and elderly women (EW) to high-resistance training. Seventeen YW (18-32 yr) and 11 EW (64-79 yr) were assessed for 1) electrically evoked relaxation time and rate of the quadriceps femoris; and 2) maximal rates of SR Ca2+ uptake and Ca2+-ATPase activity and relative fiber-type areas, analyzed from muscle biopsies of the vastus lateralis. EW had significantly slower relaxation rates and times, decreased SR Ca2+ uptake and Ca2+-ATPase activity, and a larger relative type I fiber area than did YW. A subgroup of 9 young (YWT) and 10 elderly women (EWT) performed 12 wk of high-resistance training (8 repetition maximum) of the quadriceps and underwent identical testing procedures pre- and posttraining. EWT significantly increased their SR Ca2+ uptake and Ca2+-ATPase activity in response to training but showed no alterations in speed of relaxation or relative fiber-type areas. In YWT none of the variables was altered after resistance training. These findings suggest that 1) a reduced SR Ca2+ uptake in skeletal muscle of elderly women was partially reversed with resistance training and 2) SR Ca2+ uptake in the vastus lateralis was not the rate-limiting mechanism for the slowing of relaxation measured from electrically evoked quadriceps muscle of elderly women.

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Section: Reductions In Sr Ca 2ϩ Uptake and Sr Ca 2ϩ -Atpase Activity supporting

confidence: 91%

Human skeletal sarcoplasmic reticulum Ca²⁺uptake and muscle function with aging and strength training

Hunter¹,

Thompson²,

Ruell³

et al. 1999

Journal of Applied Physiology

126

109

View full text Add to dashboard Cite

show abstract

“…1989). We have also failed to find an effect of either high resistance training or prolonged cycle training, conducted for 11–12 weeks, on Ca 2+ ‐ATPase activity of the vastus lateralis (Green et al. 1995).…”

Section: Sarcoplasmic Reticulum Ca2+‐atpasementioning

confidence: 90%

Cation pumps in skeletal muscle: potential role in muscle fatigue.

Green

1998

Acta Physiologica Scandinavica

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Two membrane bound pumps in skeletal muscle, the sarcolemma Na+-K+ adenosine triphosphatase (ATPase) and the sarcoplasmic reticulum Ca2+-ATPase, provide for the maintenance of transmembrane ionic gradients necessary for excitation and activation of the myofibrillar apparatus. The rate at which the pumps are capable of establishing ionic homeostasis depends on the maximal activity of the enzyme and the potential of the metabolic pathways for supplying adenosine triphosphate (ATP). The activity of the Ca2+-ATPase appears to be expressed in a fibre type specific manner with both the amount of the enzyme and the isoform type related to the speed of contraction. In contrast, only minimal differences exist between slow-twitch and fast-twitch fibres in Na+-K+ ATPase activity. Evidence is accumulating that both active transport of Na+ and K+ across the sarcolemma and Ca2+-uptake by the sarcoplasmic reticulum may be impaired in vivo in a task specific manner resulting in loss of contractile function. In contrast to the Ca2+-ATPase, the Na+-K+ ATPase can be rapidly upregulated soon after the onset of a sustained pattern of activity. Similar programmes of activity result in a downregulation of Ca2+-ATPase but at a much later time point. The manner in which the metabolic pathways reorganize following chronic activity to meet the changes in ATP demand by the cation pumps and the degree to which these adaptations are compartmentalized is uncertain.

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Muscular Factors in Endurance

Green¹

2000

Endurance in Sport

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FAILURE OF HIGH RESISTANCE AND SUBMAXIMAL EXERCISE TRAINING TO ALTER SARCOPLASMIC RETICULUM Ca2* ATPase IN HUMAN MUSCLE.

Cited by 5 publications

References 0 publications

Human skeletal sarcoplasmic reticulum Ca²⁺uptake and muscle function with aging and strength training

Human skeletal sarcoplasmic reticulum Ca²⁺uptake and muscle function with aging and strength training

Cation pumps in skeletal muscle: potential role in muscle fatigue.

Muscular Factors in Endurance

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FAILURE OF HIGH RESISTANCE AND SUBMAXIMAL EXERCISE TRAINING TO ALTER SARCOPLASMIC RETICULUM Ca2* ATPase IN HUMAN MUSCLE.

Cited by 5 publications

References 0 publications

Human skeletal sarcoplasmic reticulum Ca2+uptake and muscle function with aging and strength training

Human skeletal sarcoplasmic reticulum Ca2+uptake and muscle function with aging and strength training

Cation pumps in skeletal muscle: potential role in muscle fatigue.

Muscular Factors in Endurance

Contact Info

Product

Resources

About

Human skeletal sarcoplasmic reticulum Ca²⁺uptake and muscle function with aging and strength training

Human skeletal sarcoplasmic reticulum Ca²⁺uptake and muscle function with aging and strength training