Failure of Postexposure Treatment of Rabies in Children

30 years of rabies vaccination with Rabipur: a summary of clinical data and global experience

“…However, investigation into these cases shows that for the majority of patients there was an omission of at least one of the essential steps of PEP (wound treatment, administration of RIG and complete course of vaccine) [85][86][87][88][89]. Physicians should be advised that immediate and correct PEP management without delay according to official recommendations is essential for patient survival.…”

Evaluation of Rabies Biologics against Irkut Virus Isolated in China

“…It is possible that PEP models with longer incubation periods or situations involving real-life exposures would allow sufficient time for the development of active immune responses to vaccination and would protect animals and humans against IRKV infection, as may be inferred from our PrEP experiments. However, short incubation periods may occur after reallife exposures as well (29), and this increases the demand for the development of novel immunoglobulin preparations (including MAbs) for protection against IRKV and other non-RABV lyssaviruses.…”

Passive Immunity in Prevention and Treatment of Infectious Diseases

“…Wilde et al (188) recognized the difficulty in infiltrating multiple wounds on the face, head, arms, and hands with a small volume of immune globulin and recommended dilution to ensure infiltration around every wound. The World Health Organization recommendations state that sterile saline can be used to dilute RIG two-to threefold to permit thorough infiltration (193).…”