Failure of transfusion of autologous whole blood to reduce banked-blood requirements in open-heart surgical patients

Pliam, Michael B.; McGoon, Dwight C.; Tarhan, Sait

doi:10.1016/s0022-5223(19)40359-0

Cited by 43 publications

(6 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…12 Sherman and colleagues 13 showed no difference in blood loss with ANH, the requirement for allogeneic blood actually being greater in their ANH group than in the group of patients serving as controls. Pliam and colleagues 14 showed that the requirements of allogeneic blood tended to be even greater after ANH (although the difference did not reach statistical significance). The reason for the discrepancy in the results is probably related to the fact that most of the reports on this topic included only small numbers of patients, were not randomized, or had no predefined criteria.…”

Section: Discussionmentioning

confidence: 98%

“…Pliam and colleagues 14 showed that the requirements of allogeneic blood tended to be even greater after ANH (although the difference did not reach statistical signifi cance). The reason for the discrepancy in the results is probably related to the fact that most of the reports on this topic included only small numbers of patients, were not randomized, or had no predefi ned criteria.…”

Section: Discussionmentioning

confidence: 98%

See 1 more Smart Citation

Effects of Tranexamic Acid and Autotransfusion in Coronary Artery Bypass

Mehraein

Davoodi

Madani-Civi

2007

Asian Cardiovasc Thorac Ann

View full text Add to dashboard Cite

The aim of this study was to compare the effects of intraoperative autotransfusion and tranexamic acid on postoperative bleeding and the need for allogeneic transfusion. In a prospective randomized study, 200 patients undergoing coronary artery bypass were divided into two groups: 100 patients received 1-2 units of autologous blood after termination of cardiopulmonary bypass; and 100 patients were given tranexamic acid 15 mg x kg(-1) before injection of heparin and again before injection of protamine. Postoperative bleeding was significantly lower in the tranexamic acid group (600 mL) than the autotransfusion group (1,100 mL). The percentage of patients transfused in the autotransfusion and tranexamic acid groups was 70% and 65%, respectively. Patients in the autotransfusion group received significantly more whole blood (2.82 vs 1.93 units). Intensive care and hospital stays were shorter in the tranexamic acid group. There was no hospital mortality and no difference in thrombotic complications between groups. Tranexamic acid was more effective than autotransfusion in reducing postoperative blood loss and allogeneic transfusions after coronary bypass.

show abstract

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 98%

Effects of Tranexamic Acid and Autotransfusion in Coronary Artery Bypass

Mehraein

Davoodi

Madani-Civi

2007

Asian Cardiovasc Thorac Ann

View full text Add to dashboard Cite

show abstract

“…In contrast, Pliam et al 9 and Sherman et al 10 observed no difference in postoperative blood loss or donor blood usage when they used fresh autologous blood in open heart surgery. Most of the first group of authors noted a rise of 25-30,OOO/mml in the platelet count after autologous blood transfusion but in none of these studies (summarised in Table 1) was account taken of haemodilution during bypass and haemoconcentration afterwards.…”

mentioning

confidence: 95%

Fresh Autologous Blood Transfusion and Platelet Counts after Cardiopulmonary Bypass Surgery

1982

Anaesth Intensive Care

View full text Add to dashboard Cite

The effect of fresh autologous blood transfusion on platelet count and blood requirement in the early postoperative period is examined in a control group and in patients receiving early and late autologous replacement. Withdrawal of blood in the autologous groups appeared to enhance platelet numbers as the autologous groups had higher mean platelet counts than the control group immediately after bypass, in spite of having lower mean haematocrit. After bypass all groups showed a progressive rise in platelet count with time. A substantial part of the rise was explained by haemoconcentration resulting from fluid shifts but there was also an increase in the total circulating platelet numbers. There was no difference in postoperative blood loss between the three groups. Autologous blood replacement hastens the postoperative rise in platelet count but does not alter the postoperative blood loss.

show abstract

“…Some authors suggest inconclusive results regarding the effect of autotransfusion from the use of heparin as an anticoagulation method. 5,6 The aim of our trial was to evaluate the effectiveness of intraoperative whole blood sequestration, comparing heparin and citrate as anticoagulants, for decreasing blood loss and use of allogeneic blood products.…”

mentioning

confidence: 99%