Failure to demonstrate Borna disease virus genome in peripheral blood mononuclear cells from psychiatric patients in Korea

Kim, Yong Ku; Kim, Sang Hyun; Choi, Seongcheol; Ko, Young Hoon; Lee, Heon Jeong; Lee, Min Soo; Suh, Kwang Yoon; Kwak, D I; Song, Ki-Joon; Lee, Yong Ju; Yanagihara, Richard; Song, Jin-Won

doi:10.3109/13550289909022002

Cited by 27 publications

(14 citation statements)

References 25 publications

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“…The prevalence of BDV RNA in psychiatric (schizophrenic) patients (1.8%) was not significantly different from that of healthy volunteers (0.6%), both of which was less than those reported by other Japanese groups [Kishi et al, 1995;Kubo et al, 1997;Iwata et al, 1998]. Our results, however, agreed with reports that there was no association between BDV and psychiatric diseases in Japan and Korea [Haga et al, 1997;Kubo et al, 1997;Iwata et al, 1998;Kim et al, 1999]. It is not known why there were no PBMC samples that both p24 and p40 RNA were detected simultaneously.…”

Section: Discussioncontrasting

confidence: 37%

“…The detection of BDV RNA in PBMCs from neuropsychiatric and chronic fatigue syndrome patients has been also reported Kishi et al, 1995;Kitani et al, 1996;Sauder et al, 1996]. In contrast to these findings, other groups recently found that there was no association between BDV infection and neuropsychiatric disorders or chronic fatigue syndrome [Haga et al, 1997;Kubo et al, 1997;Lieb et al, 1997;Iwata et al, 1998;Bachman et al, 1999;Kim et al, 1999]. The reason for this discrepancy is not known yet.…”

Section: Introductionmentioning

confidence: 39%

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No association of Borna disease virus with psychiatric disorders among patients in Northern Kyushu, Japan

et al. 2000

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There is controversy over the prevalence of Borna disease virus (BDV) antibodies and its RNA in the peripheral blood mononuclear cells (PBMCs) of psychiatric patients, and the contribution of BDV to human psychiatric disorders. We examined 299 plasma and 229 PBMC samples. No plasma samples were positive for BDV-p40, p24 or gp18 antibodies by western blot analysis. The prevalence of BDV RNA in the psychiatric (schizophrenic) patients (1.8%) was not significantly different from that in the healthy volunteers (0.6%). The nucleotide sequences of BDV p40 and p24 were highly conserved with those of BDV He/80. Our results suggested that there is a lack of association between BDV infection and psychiatric disorders among the patients in Northern Kyushu, Japan.

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Section: Discussioncontrasting

confidence: 37%

Section: Introductionmentioning

confidence: 39%

No association of Borna disease virus with psychiatric disorders among patients in Northern Kyushu, Japan

et al. 2000

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“…Another NMDA receptor antagonist, ketamine, also has antidepressant effects [46], which appear to be mediated by changes in mTOR signaling [47]. However, the literature on BDV infection and depression remains controversial, with several studies failing to replicate any association between the two [48-51]. …”

Section: Introductionmentioning

confidence: 99%

Reconceptualizing major depressive disorder as an infectious disease

Canli

2014

Biol Mood Anxiety Disord

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In this article, I argue for a reconceptualization of major depressive disorder (major depression) as an infectious disease. I suggest that major depression may result from a parasitic, bacterial, or viral infection and present examples that illustrate possible pathways by which these microorganisms could contribute to the etiology of major depression. I also argue that the reconceptualization of the human body as an ecosystem for these microorganisms and the human genome as a host for non-human exogenous sequences may greatly amplify the opportunity to discover genetic links to the illness. Deliberately speculative, this article is intended to stimulate novel research approaches and expand the circle of researchers taking aim at this vexing illness.

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“…Large amounts of plasma antigens were detected in a cohort of severely depressed patients by ELISA and the severity of symptoms appeared to correlate with the concentration and duration of antigenaemia. [46] In contrast, the presence of antigen in plasma occurs rarely [73] Healthy controls 0 (0/26) Germany p40 Various manifestations 0 (0/159) Lieb et al [75] Japan p24 Blood donors 57.10 Takashiet et al [76] USA and p24, p40 Various manifestations 0 (0/52) Richi et al [77] Germany [79] Taiwan p24, p40 Schizophrenia 13.5 (10/74) Chen et al [80] Healthy controls…”

Section: Detection Of Circulating Plasma Antigens and Cicsmentioning

confidence: 99%

Role of Borna Disease Virus in Neuropsychiatric Illnesses: Are We Inching Closer?

Thakur

Sarma

Sharma

2009

Indian Journal of Medical Microbiology

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The biological cause of psychiatric illnesses continues to be under intense scrutiny. Among the various neurotropic viruses, Borna disease virus (BDV) is another virus that preferentially targets the neurons of the limbic system and has been shown to be associated with behavioural abnormalities. Presence of various BDV markers, including viral RNA, in patients with affective and mood disorders have triggered ongoing debate worldwide regarding its aetiopathogenic relationship. This article analyses its current state of knowledge and recent advances in diagnosis in order to prove or refute the association of BDV in causation of human neuropsychiatric disorders. This emerging viral causative association of behavioural disorders, which seems to be inching closer, has implication not only for a paradigm shift in the treatment and management of neuropsychiatric illnesses but also has an important impact on the public health systems.

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Failure to demonstrate Borna disease virus genome in peripheral blood mononuclear cells from psychiatric patients in Korea

Cited by 27 publications

References 25 publications

No association of Borna disease virus with psychiatric disorders among patients in Northern Kyushu, Japan

No association of Borna disease virus with psychiatric disorders among patients in Northern Kyushu, Japan

Reconceptualizing major depressive disorder as an infectious disease

Role of Borna Disease Virus in Neuropsychiatric Illnesses: Are We Inching Closer?

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