Failure to demonstrate tumour-associated transplantation antigens on asbestos-induced mesotheliomas in rats

Brown, D G; Wagner, J. C.; Wagner, M.

doi:10.1038/bjc.1980.316

Cited by 3 publications

(1 citation statement)

References 14 publications

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“…Similarly, Brown et al. (14) reported that asbestos-induced transplantable rat mesothelioma cells do not exhibit tumor-associated transplantation antigens. This was deduced by the failure of such cells to bring forth immune responses capable of inhibiting subsequent growth of the transplantable mesothelioma upon rechallenge.…”

Section: Resultsmentioning

confidence: 95%

Cell-Mediated Cytotoxicity Expressed by Lymphoid Cells from Rats with Asbestos-Induced Peritoneal Mesothelioma towards Rat Fetal Cell

Stevens¹,

Cole²,

Cheng³

et al. 1983

Environmental Health Perspectives

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Cell-mediated immunity (CMI) directed towards rat fetal cells was evaluated in Fischer F344 young inbred male rats having asbestos-induced peritoneal mesothelioma. The tumors were induced by exposure to Canadian chrysotile B fibers and the CMI delineated by the injury and destruction brought about to 6to 10-day-old primary fetal cell cultures by the so-called educated peripheral blood lymphoid-cells (PBLC) obtained from the cancer-bearing rats. A significant cytotoxicity was found to be expressed by the PBLCs, suggesting that during the development of mesothelioma, a cellular retrodifferentiation occurs, thereby educating the effectors to recognize a common determinant existing in both the tumor and fetal cells. Educated PBLCs were produced from rats having endodermal tissue cancers (adenocarcinomas of the small bowel, colon and pancreas) and were found to also be cytotoxic to the fetal cultures, yet no injury was apparently inflicted upon cultured mesothelioma target cells by these effectors. These results suggested that the tumor education was specific and that probably a unique and different fetal component was being recognized by the effector cells obtained from the rats with lesions arising either in the mesodermal or endodermal tissue. Further support for this concept was the failure of an antibody, specific to an oncofetal protein existing in endodermal lesions, to apparently recognize any common oncogenic proteins in the mesothelioma. Preliminary studies have also been accomplished which suggests the existence of natural killing immune responses existing to the mesothelioma target cells. These results, in contrast to other recently reported findings, certainly intimate that asbestos-induced mesothelioma indeed results in host antitumor immune responses and that immune therapy along with immunodiagnosis may in actuality prove to serve an important clinical role in the management of this form of cancer.

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Section: Resultsmentioning

confidence: 95%

Cell-Mediated Cytotoxicity Expressed by Lymphoid Cells from Rats with Asbestos-Induced Peritoneal Mesothelioma towards Rat Fetal Cell

Stevens¹,

Cole²,

Cheng³

et al. 1983

Environmental Health Perspectives

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Histology and ultrastructure of serially transplanted rat mesotheliomas

Wagner¹,

Johnson²,

Brown³

et al. 1982

Br J Cancer

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Cell-mediated cytotoxicity expressed by lymphoid cells from rats with asbestos-induced peritoneal mesothelioma towards rat fetal cell.

Stevens¹,

Cole²,

Cheng³

et al. 1983

Environ Health Perspect

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Cell-mediated immunity (CMI) directed towards rat fetal cells was evaluated in Fischer F344 young inbred male rats having asbestos-induced peritoneal mesothelioma. The tumors were induced by exposure to Canadian chrysotile B fibers and the CMI delineated by the injury and destruction brought about to 6- to 10-day-old primary fetal cell cultures by the so-called educated peripheral blood lymphoid-cells (PBLC) obtained from the cancer-bearing rats. A significant cytotoxicity was found to be expressed by the PBLCs, suggesting that during the development of mesothelioma, a cellular retrodifferentiation occurs, thereby educating the effectors to recognize a common determinant existing in both the tumor and fetal cells. Educated PBLCs were produced from rats having endodermal tissue cancers (adenocarcinomas of the small bowel, colon and pancreas) and were found to also be cytotoxic to the fetal cultures, yet no injury was apparently inflicted upon cultured mesothelioma target cells by these effectors. These results suggested that the tumor education was specific and that probably a unique and different fetal component was being recognized by the effector cells obtained from the rats with lesions arising either in the mesodermal or endodermal tissue. Further support for this concept was the failure of an antibody, specific to an oncofetal protein existing in endodermal lesions, to apparently recognize any common oncogenic proteins in the mesothelioma. Preliminary studies have also been accomplished which suggests the existence of natural killing immune responses existing to the mesothelioma target cells.(ABSTRACT TRUNCATED AT 250 WORDS)

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Failure to demonstrate tumour-associated transplantation antigens on asbestos-induced mesotheliomas in rats

Cited by 3 publications

References 14 publications

Cell-Mediated Cytotoxicity Expressed by Lymphoid Cells from Rats with Asbestos-Induced Peritoneal Mesothelioma towards Rat Fetal Cell

Cell-Mediated Cytotoxicity Expressed by Lymphoid Cells from Rats with Asbestos-Induced Peritoneal Mesothelioma towards Rat Fetal Cell

Histology and ultrastructure of serially transplanted rat mesotheliomas

Cell-mediated cytotoxicity expressed by lymphoid cells from rats with asbestos-induced peritoneal mesothelioma towards rat fetal cell.

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