Pre-Menstrual Syndrome (PMS) complaints occur in women with different complaints and causes. This research aimed to determine the determinants of Pre-Menstrual Syndrome complaints in women workers in Makassar City. This type of research is analytics observational, with 203 women workers as a sample that was obtained through the purposive sampling technique. The research was conducted in Makassar City by distributing online questionnaires. This study showed that as many as 188 respondents (92.60%) had experienced PMS complaints with determinants of marital status, exercise, depression, consumption of foods high in salt, and knowledge about PMS. This study concludes that there is no relationship between marital status, exercise, depression, physical trauma, consuming high salt, and knowledge of PMS complaints. This study suggests that women workers, especially in Makassar City, can increase their knowledge about PMS and how to prevent it, improve sleep patterns, exercise regularly, avoid the consumption of foods high in salt, and increase the consumption of fruits and vegetables. Furthermore, the company should identify women workers who experience PMS complaints to carry out valid complaints. Women workers can find out the determinants of premenstrual syndrome complaints, and women workers can increase their knowledge about premenstrual syndrome and prevent the causes of premenstrual syndrome