False-Positive FDG Positron Emission Tomography in Pulmonary Amyloidosis

Standardized uptake value and radiological density attenuation as predictive and prognostic factors in patients with solitary pulmonary nodules: our experience on 1,592 patients

“…Visual assessment is based upon comparison between FDG lesion uptake and mediastinum (12), but nodules with similar FDG uptake to the mediastinal pool are challenging; for these reasons, a 2.5 cut off the SUVmax has been used for the establishment of malignancy. However, FDG and its avidity is not tumor-specific and an increased uptake is reported in benign diseases (13)(14)(15)(16). On the other hand, malignancies can be poorly avid leading to mistaken conclusions or interpretation of findings (17)(18)(19).…”

18F-FDG PET Scanning in Pulmonary Amyloidosis

“…The role of 18 F-FDG PET scanning in patients with amyloidosis has been unclear, with only a few case reports relevant to this issue having been published (3,(7)(8)(9)(10)(11)(12). In addition, the few retrospective studies that have been published on the role of 18 F-FDG PET in patients with MALT lymphoma have yielded conflicting results (13)(14)(15)(16)(17).…”

Mimicking pulmonary multiple metastatic tumors: A case of primary nodular parenchymal pulmonary amyloidosis with review of the literature

“…Furthermore, certain noncancerous conditions may also demonstrate high metabolic rates (26). Increased 18 F-FDG activity has been demonstrated in cases of tuberculosis, sarcoidosis, fungal disease, interstitial lung disease, osteoarthritis, vascular thromboses, osteoporosis and rheumatoid nodules (27)(28)(29). The reason that noncancerous conditions uptake 18 F-FDG may be due to lesions with a high concentration of inflammatory cells, including neutrophils and activated macrophages, which increase glucose uptake (30,31).…”