False-Positive Results in Serologic Tests for Rocky Mountain Spotted Fever During Pregnancy

Kj, Welch; Rl, Rumley; Ja, Levine

doi:10.1097/00007611-199103000-00005

Cited by 4 publications

(2 citation statements)

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“…Literature around RMSF during pregnancy has been limited. 3 4 5 6 7 8 9 10 In endemic regions, especially eastern and south-central United States, the presence of a fever, transaminitis, thrombocytopenia, and rash in any patient with a history of a tick bite, pregnant or not, presumes the diagnosis, and empiric therapy should be started. However, in the setting of pregnancy, even in an endemic area, the differential diagnosis for fever with transaminitis and thrombocytopenia includes a number of other infectious diseases (rubella, streptococcal toxic shock syndrome, and Epstein–Barr virus) as well as immunologic and rheumatologic causes (immunologic thrombocytopenic purpura).…”

Section: Discussionmentioning

confidence: 99%

Atypical Presentation of Rocky Mountain Spotted Fever in Pregnancy

Wu,

Dotters-Katz,

Varvoutis

2024

AJP Rep

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Rocky Mountain spotted fever (RMSF) is a common tick-borne disease and can have variable presentation with potentially fatal outcomes when untreated. We describe an atypical presentation of RMSF in the third trimester. A 37-year-old multiparous woman at 310/7 weeks' gestation presented normotensive with headaches and fever but no rash or significant tick exposure. She was initially treated for atypical hemolysis, elevated liver enzymes, and low platelet count syndrome but further decompensated, requiring intensive care unit transfer, intubation, and emergent delivery. Doxycycline administration was associated with marked improvement with no significant sequalae to mother or infant. Later convalescent serologies were positive for RMSF. RMSF is a clinically challenging diagnosis in pregnancy. Given significant morbidity and mortality associated with delayed treatment, high suspicion in endemic areas is needed, and prompt antibiotic use with doxycycline should be administered.

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Section: Discussionmentioning

confidence: 99%

Atypical Presentation of Rocky Mountain Spotted Fever in Pregnancy

Wu,

Dotters-Katz,

Varvoutis

2024

AJP Rep

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“…The disease severity ranges 638 Obstetrical and Gynecological Survey from a mild malaise to death. 94,95 Other diseases caused by bacteria in this family include epidemic typhus (Rickettsia prowazekii), murine typhus (Rickettsia typhi), and scrub typhus, which is caused by Orientia tsutsugamushi. 94,95 Other diseases caused by bacteria in this family include epidemic typhus (Rickettsia prowazekii), murine typhus (Rickettsia typhi), and scrub typhus, which is caused by Orientia tsutsugamushi.…”

Section: Rickettsial Diseases In Pregnancymentioning

confidence: 99%

Arthropod-Borne Bacterial Diseases in Pregnancy

Dotters‐Katz¹,

Kuller²,

Heine³

2013

Obstetrical &Amp; Gynecological Survey

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Arthropod-borne bacterial diseases affect more than 25,000 Americans every year and thousands more around the world. These infections present a diagnostic dilemma for clinicians because they mimic many other pathologic conditions and are often low on or absent from the differential diagnosis list. Diagnosis is particularly challenging during pregnancy, as these infections may mimic common pregnancy-specific conditions, such as typical and atypical preeclampsia, or symptoms of pregnancy itself. Concerns regarding the safety in pregnancy of some indicated antibiotics add a therapeutic challenge for the prescriber, requiring knowledge of alternative therapeutic options for many arthropod-borne bacterial diseases. Physicians, especially those in endemic areas, must keep this class of infections in mind, particularly when the presentation does not appear classic for more commonly seen conditions. This article discusses presentation, diagnosis, and treatment of the most common of these arthropod-borne bacterial diseases, including Lyme disease, Rocky Mountain spotted fever, tick-borne relapsing fever, typhus, plague, cat-scratch disease, and Carrión disease.

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Zeckenübertragbare Infektionen

Hebisch¹

1998

Infektionserkrankungen Der Schwangeren Und Des Neugeborenen

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False-Positive Results in Serologic Tests for Rocky Mountain Spotted Fever During Pregnancy

Cited by 4 publications

References 0 publications

Atypical Presentation of Rocky Mountain Spotted Fever in Pregnancy

Atypical Presentation of Rocky Mountain Spotted Fever in Pregnancy

Arthropod-Borne Bacterial Diseases in Pregnancy

Zeckenübertragbare Infektionen

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