Familial Abdominal and Intestinal Lipomatosis Presenting with Upper GI Bleeding

Abstract

Although lipomas are encapsulated benign tumors, systemic lipomatosis defines infiltrative nonencapsulated tumors resembling normal adipose tissue. Abdominal lipomatosis and intestinal lipomatosis are different clinicopathological entities with similar clinical symptoms. We describe here a case presenting with upper gastrointestinal bleeding from eroded submucosal lipoma at duodenum secondary to intestinal lipomatosis and abdominal lipomatosis.

Gastroduodenal Lipomatosis in Familial Multiple Lipomatosis

“…Our case is similar to that in Bilgic et al [3] , which is a report on a patient with multiple gastroduodenal lipomas associated with abdominal visceral adiposity and a solitary, subcutaneous lipoma on his neck; the patient's father had mobile, nontender, sub- Color version available online cutaneous lesions, with no evidence of gastrointestinal lipomas [3] . No karyotype or molecular genetic analysis was conducted for our patient; this was performed in several published studies on FML [7,8] .…”

“…The glucose and lipid profiles of the patient were normal, similar to previous cases [1,3] . The superior evidence of mass density, shape, homogeneity, location, and extensions of this were well visualized on CT, similar to what has been reported previously [2] .…”

“…Gastrointestinal lipomas associated with FML like this case are very rare, with only 9 cases having been reported, namely, colonic lipoma [3] , intestinal lipoma [4,5] , and brain and cardiac lipoma [6,7] . Our case is similar to that in Bilgic et al [3] , which is a report on a patient with multiple gastroduodenal lipomas associated with abdominal visceral adiposity and a solitary, subcutaneous lipoma on his neck; the patient's father had mobile, nontender, sub- Color version available online cutaneous lesions, with no evidence of gastrointestinal lipomas [3] .…”

Gastric lipomatosis

“…However, the most likely explanation is an embryogenic misplacement of adipocytes [4]. Gastric lipomatosis may be also an effect of chronic chemical or physical irritation [4], congenital predisposition, lipid storage diseases, chronic inflammatory bowel disease, hamartomatous syndromes [1], post-chemotherapeutic fat deposition and alcohol consumption, that apart from causing folate deficiency and macrocytic anemia, promotes lipomas through effects on adipocytes [6]. In some cases, family history of this disease has also been confirmed.…”

An unusual clinical presentation of colonic lipomatosis: A case report

“…It is generally first discovered between 50 and 65 years of age and has a predominance for women. The most frequently involved localizations are the ileocecal valve (ICV) and the ascending colon [ 3 ].…”