Familial adenomatous polyposis syndrome with colorectal cancer in two Nigerians: a report of two cases and review of literature

Abstract

Familial adenomatous polyposis syndrome is a rare condition characterized by the presence of numerous adenomatous polyps in the gastrointestinal tract and associated with risk for colorectal cancer. The disease is scarcely reported in Nigeria and this is the index report in Ilorin. Two cases were clinically diagnosed in our facility. They both presented with gastrointestinal bleeding and numerous rectal and colonic polyps were identified at colonoscopy. Histological examination of the polyps in both cases revealed features in keeping with adenomatous polyps. This report highlights the occurrence of this precancerous condition.

Clinicopathological Characteristics and Mutational Landscape of APC, HOXB13, and KRAS among Rwandan Patients with Colorectal Cancer

“…Germline mutations in APC are also key factors in familial adenomatous polyposis syndrome. This syndrome is quasi-nonexistent in African populations, with only a few cases having ever been reported in the literature [54][55][56][57][58][59][60][61][62][63]. Mutations in the APC gene in CRC have been reported in more than 50% of cases [44].…”

Role of different polyphenols in the treatment of cancer disease

“…Lynch syndrome is one such condition which falls within hereditary colorectal cancer syndrome and is caused by mutation in one of the DNA mismatch-repair genes: mutL homolog 1(MLH1), mutS homolog 2 (MSH2), mutS homolog 6 (MSH6), PMS2 or epithelial cell adhesion molecule (EpCAM) (Kuipers et al, 2015). Another most common colorectal cancer syndrome is familial adenomatous polyposis, characterized by the presence of hundreds to thousands of polyps in the colon and rectum and occurs due to mutation in adenomatous polyposis coli (APC) gene www.ajpp.in (Bojuwoye et al, 2018). Patients with chronic colitis with inflammatory bowel disease (IBD) are also associated with increased risk of cancer (Keller et al, 2019).…”