Familial aggregation of early-onset myocardial infarction

Cipriani, Valentina; Mannucci, Pier Mannuccio; Ardissino, Diego; Ferrario, Maurizio; Corsini, G; Merlini, Piera Angelica; Notarangelo, Francesca M.; Lina, Daniela; Bernardinelli, Luisa

doi:10.1016/j.ejim.2010.07.017

Cited by 18 publications

(14 citation statements)

References 17 publications

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“…IHD has a complicated genetic component (22,23); previous studies of myocardial infarction have identified patterns similar to those we observed (11,21,24). Although our conclusions regarding the effect of a family history of premature cardiovascular death on risk of early IHD were unaffected by adjustment for diabetes, hypertension, and hyperlipidemia, the effects of sibling and half-sibling deaths decreased substantially, indicating that a large component of these associations is explained by the additional risk factors.…”

Section: Ischemic Heart Diseasesupporting

confidence: 60%

“…Earlier studies have lacked power and/or control groups, and have been limited by selection of heavily affected families (6,(11)(12)(13) and self-reported family history of cardiovascular events (e.g., "heart attack" [13] or "sudden cardiac death" [8,9]). We aimed to address these limitations by studying family history of premature death and subsequent risk of early cardiovascular disease in a cohort study based on all residents of Denmark.…”

Section: Discussionmentioning

confidence: 99%

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Family History of Premature Death and Risk of Early Onset Cardiovascular Disease

Ranthe

Carstensen

Øyen

et al. 2012

Journal of the American College of Cardiology

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Section: Ischemic Heart Diseasesupporting

confidence: 60%

Section: Discussionmentioning

confidence: 99%

Family History of Premature Death and Risk of Early Onset Cardiovascular Disease

Ranthe

Carstensen

Øyen

et al. 2012

Journal of the American College of Cardiology

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“…While the effect of parental history of premature cardiac events (<55 years old in men, <65 in women) and the effects of advanced age on CVD risk is well-studied [26,27], no research has been done on assessing the risk of a unit increase or decrease of parental age of onset of CVD and offspring age of onset of CVD while controlling for modifiable risk factors. Establishing this relationship on a continuous scale as compared to thresholding at age 55 years and 65 years will lead to a more powerful test and a better prediction of offspring age of CVD onset.…”

Section: Introductionmentioning

confidence: 99%

Parental Age of Onset of Cardiovascular Disease as a Predictor for Offspring Age of Onset of Cardiovascular Disease

et al. 2016

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ObjectiveThe risk for cardiovascular disease (CVD) is higher for individuals with a first-degree relative who developed premature CVD (with a threshold at age 55 years for a male or 65 years for a female). However, little is known about the effect that each unit increase or decrease of maternal or paternal age of onset of CVD has on offspring age of onset of CVD. We hypothesized that there is an association between maternal and paternal age of onset of CVD and offspring age of onset of CVD.MethodsWe used the Framingham Heart Study database and performed conditional imputation for CVD-censored parental age (i.e. parents that didn’t experience onset of CVD) and Cox proportional regression analysis, with offspring’s age of onset of CVD as the dependent variable and parental age of onset of CVD as the primary predictor. Modifiable risk factors in offspring, such as cigarette smoking, body mass index (BMI), diabetes mellitus, systolic blood pressure (SBP), high-density lipoprotein (HDL) level, and low-density lipoprotein (LDL) level, were controlled for. Separate analyses were performed for the association between maternal age of onset of CVD and offspring age of onset of CVD and the association between paternal age of onset of CVD and offspring age of onset of CVD.ResultsParental age of onset of CVD was predictive of offspring age of onset of CVD for maternal age of onset of CVD (P < .0001; N = 1401) and for paternal age of onset of CVD (P = 0.0134; N = 1221). A negative estimate of the coefficient of interest signifies that late onset of cardiovascular events in parents is protective of onset of CVD in offspring. Cigarette smoking and HDL level were important associated confounders.ConclusionsOffspring age of onset of cardiovascular disease is significantly associated with both maternal and paternal age of onset CVD. The incorporation of the parameters, maternal or paternal age of onset of CVD, into risk estimate calculators may improve accuracy of identification of high-risk patients in clinical settings.

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“…4 It has also been suggested that especially early-onset MI exhibits familial clustering. 7 Despite these previous studies, literature on the subject is scarce. Such previous studies were mostly small and obtained family history through questionnaires-a method prone to bias.…”

Section: Introductionmentioning

confidence: 99%

Familial clustering of myocardial infarction in first-degree relatives: a nationwide study

Nielsen

Andersson

Gerds

et al. 2013

European Heart Journal

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AimsFamily history is an established risk factor for myocardial infarction (MI), but it is not clear how this risk changes with number and gender of first-degree relatives with MI. We used the entire Danish population to examine the importance of MI in siblings and parents. Methods and resultsThis study is a retrospective nationwide register-based cohort study including registered relatives to all Danish citizens diagnosed with MI in the period 1978-2010. In the entire Danish population we identified siblings to 7552 patients with a first-time MI. The rate ratios (RR) calculated by Poisson models showed an RR of 4.30 (95% confidence interval 3.53 -5.23) for siblings of a patient with MI. Children of parents with MI also showed high risk: for children of a maternal case RR 2.40 (2.20-2.60), and of a paternal case RR 1.98 (1.98-2.09), respectively; P value for gender interaction ,0.0001. A paternal case with MI at an age ,50 years was associated with an RR of 3.30 (2.92-3.72) while a case .50 years was associated with a risk of 1.83 (1.73-1.93). For maternal cases below and above 50 years of age the risks were 3.23 (2.56-4.10) and 2.31 (2.11-2.52), respectively. ConclusionFirst-degree relatives of a patient with myocardial infarction themselves have a substantial higher risk of myocardial infarction. The risk is particularly elevated when the MI case is the mother or a sibling, and when the MI case has the infarction before the age of 50 years.--

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Familial aggregation of early-onset myocardial infarction

Cited by 18 publications

References 17 publications

Family History of Premature Death and Risk of Early Onset Cardiovascular Disease

Family History of Premature Death and Risk of Early Onset Cardiovascular Disease

Parental Age of Onset of Cardiovascular Disease as a Predictor for Offspring Age of Onset of Cardiovascular Disease

Familial clustering of myocardial infarction in first-degree relatives: a nationwide study

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