Familial and disease specific abnormalities in the neural correlates of the Stroop Task in Bipolar Disorder

Pompei, Francesco; Jogia, Jigar; Tatarelli, Roberto; Girardi, Paolo; Rubia, Katya; Kumari, Veena; Frangou, Sophia

doi:10.1016/j.neuroimage.2011.02.052

Cited by 64 publications

(50 citation statements)

References 69 publications

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“…However, our findings are consistent with previous Stroop studies that reported reduced activation to conflict trials in IFG/MFG, medial SFG/SMA, parietal cortex, and basal ganglia in euthymic BD patients (Malhi et al, 2005;Strakowski et al, 2005;Kronhaus et al, 2006;Roth et al, 2006;Pompei et al, 2011). Stroop-like conflict has rarely been studied during affective episodes, but decreased activity in the IFG, together with hypoactivation of the basal ganglia, thalamus and/or parietal areas, was reported during inhibition and emotion categorization tasks in manic and depressed patients, as well as euthymic patients Foland-Ross et al, 2012;Vizueta et al, 2012).…”

Section: Discussionsupporting

confidence: 93%

“…In previous studies of conflict processing in bipolar disorder, euthymic patients demonstrated decreased activation in frontalparietal networks and basal ganglia structures when processing non-emotional conflict (Kronhaus et al, 2006;Pompei et al, 2011) and task-irrelevant emotional information (Malhi et al, 2005). In addition, abnormal connectivity between prefrontal and limbic/ paralimbic areas has been reported in euthymic patients during a Stroop task (Pompei et al, 2011b).…”

Section: Introductionmentioning

confidence: 93%

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Modulation of brain response to emotional conflict as a function of current mood in bipolar disorder: Preliminary findings from a follow-up state-based fMRI study

Rey¹,

Desseilles²,

Favre³

et al. 2014

Psychiatry Research: Neuroimaging

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a b s t r a c tWe used functional magnetic resonance imaging (fMRI) to examine affective control longitudinally in a group of patients with bipolar disorder (BD). Participants comprised 12 BD patients who underwent repeated fMRI scans in euthymic (n ¼ 11), depressed (n ¼9), or hypomanic (n ¼9) states, and were compared with 12 age-matched healthy controls. During fMRI, participants performed an emotional face-word interference task with either low or high attentional demands. Relative to healthy controls, patients showed decreased activation of the cognitive control network normally associated with conflict processing, more severely during hypomania than during depression, but regardless of level of task demand in both cases. During euthymia, a decreased response to conflict was observed only during the high load condition. Additionally, unlike healthy participants, patients exhibited deactivation in several key areas in response to emotion-conflict trials -including the rostral anterior cingulate cortex during euthymia, the hippocampus during depression, and the posterior cingulate cortex during hypomania. Our results indicate that the ability of BD patients to recruit control networks when processing affective conflict, and the abnormal suppression of activity in distinct components of the default mode network, may depend on their current clinical state and attentional demand.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 93%

Modulation of brain response to emotional conflict as a function of current mood in bipolar disorder: Preliminary findings from a follow-up state-based fMRI study

Rey¹,

Desseilles²,

Favre³

et al. 2014

Psychiatry Research: Neuroimaging

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“…Detailed description of the findings from the conventional fMRI analysis can be found in Pompei et al (2011). A main effect of group was observed within the superior parietal lobule (BA7) (Talairach coordinates x = 32, y = − 58, z = 43, z-value = 4.54, cluster size = 290 and x = − 20, y = −72, z = 44, z-value = 4.41, cluster size = 43), the inferior parietal lobule (BA40) (x = 34, y = −48, z = 41, z-value = 4.81, cluster size = 189 and x = −42, y = − 32, z = 50, z-value = 4.60, cluster size = 20), the head of the caudate (x = −2, y = 10, z = 1, zvalue = 4.31, cluster size = 19) and the VLPFC (inferior frontal gyrus; BA47) (x = 34, y = 26, z = − 8, z-value = 4.19, cluster size = 30) (Fig.…”

Section: Fmri Resultsmentioning

confidence: 99%

“…All participants derived from the Vulnerability Indicators to Bipolar Disorders (VIBES) study sample (Frangou, 2009;Kempton et al, 2009;Walterfang et al, 2009;Takahashi et al, 2010;Lelli-Chiesa et al, 2011;Perrier et al, 2011;Pompei et al, 2011). Patients fulfilled criteria for BD type I according to the Diagnostic and Statistical Manual of Mental Disorders, 4th edition, revised (DSM-IV) (APA, 1994) and had no family history (up to second degree) of schizophrenia or schizophrenia spectrum disorders.…”

Section: Participantsmentioning

confidence: 99%

“…Blumberg et al (2003) were the first to report VLPFC hypofunction as a trait deficit in BD using the Stroop Colour Word Task (SCWT; Stroop, 1935), considered a prototypical task of cognitive control during conflict resolution. Subsequent neuroimaging studies using variants of the Stroop test have been consistent in identifying VLPFC dysfunction in adult (Blumberg et al, 2003;Gruber et al, 2004;Malhi et al, 2005;Kronhaus et al, 2006;Roth et al, 2006;Lagopoulos and Malhi, 2007;Pompei et al, 2011;Chen et al, 2011) as well as in paediatric BD patients (Pavuluri et al, 2008). Although VLPFC dysfunction has been consistently implicated, abnormalities within the cognitive control network have also been reported in other regions notably the DLPFC (Kronhaus et al, 2006;Lagopoulos and Malhi, 2007), ACC (Strakowski et al, 2005;Roth et al, 2006) and subcortical regions (Strakowski et al, 2005;Malhi et al, 2005;Blumberg et al, 2003).…”

Section: Introductionmentioning

confidence: 95%

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Dissociable functional connectivity changes during the Stroop task relating to risk, resilience and disease expression in bipolar disorder

et al. 2011

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Dissociations of cognitive inhibition, response inhibition, and emotional interference: Voxelwise ALE meta‐analyses of fMRI studies

Hung

Gaillard

Yarmak

et al. 2018

Human Brain Mapping

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111

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Inhibitory control is the stopping of a mental process with or without intention, conceptualized as mental suppression of competing information because of limited cognitive capacity. Inhibitory control dysfunction is a core characteristic of many major psychiatric disorders. Inhibition is generally thought to involve the prefrontal cortex; however, a single inhibitory mechanism is insufficient for interpreting the heterogeneous nature of human cognition. It remains unclear whether different dimensions of inhibitory processes-specifically cognitive inhibition, response inhibition, and emotional interference-rely on dissociated neural systems. We conducted systematic meta-analyses of fMRI studies in the BrainMap database supplemented by PubMed using whole-brain activation likelihood estimation. A total of 66 study experiments including 1,447 participants and 987 foci revealed that while the left anterior insula was concordant in all inhibitory dimensions, cognitive inhibition reliably activated specific dorsal frontal inhibitory system, engaging dorsal anterior cingulate, dorsolateral prefrontal cortex, and parietal areas, whereas emotional interference reliably implicated a ventral inhibitory system, involving the ventral surface of the inferior frontal gyrus and the amygdala. Response inhibition showed concordant clusters in the fronto-striatal system, including the dorsal anterior cingulate region and extended supplementary motor areas, the dorsal and ventral lateral prefrontal cortex, basal ganglia, midbrain regions, and parietal regions. We provide an empirically derived dimensional model of inhibition characterizing neural systems underlying different aspects of inhibitory mechanisms. This study offers a fundamental framework to advance current understanding of inhibition and provides new insights for future clinical research into disorders with different types of inhibition-related dysfunctions.

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Familial and disease specific abnormalities in the neural correlates of the Stroop Task in Bipolar Disorder

Cited by 64 publications

References 69 publications

Modulation of brain response to emotional conflict as a function of current mood in bipolar disorder: Preliminary findings from a follow-up state-based fMRI study

Modulation of brain response to emotional conflict as a function of current mood in bipolar disorder: Preliminary findings from a follow-up state-based fMRI study

Dissociable functional connectivity changes during the Stroop task relating to risk, resilience and disease expression in bipolar disorder

Dissociations of cognitive inhibition, response inhibition, and emotional interference: Voxelwise ALE meta‐analyses of fMRI studies

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