Familial and individual variation in chromosome fragility

Smeets, Dominique; Verhagen, Anja P. M.; Hustinx, T. W. J.

doi:10.1016/0027-5107(89)90073-0

Cited by 6 publications

(1 citation statement)

References 28 publications

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“…Individual variations in the number of spontaneous chromosomal breaks have been reported (Craig-Holmes et al 1987;Rao eta. 1988;Smeets et al 1989), although the relationship between individual variation and menstrual cycle has not been described. In this study, both the frequency of spontaneous chromosomal breaks and SCE tended to increase in the luteal phase, but the differences were small and were not statistically significant, in contrast to the results of D' Souza et al (1988).…”

Section: Discussionmentioning

confidence: 99%

Changes of common fragile sites on chromosomes according to the menstrual cycle

Furuya

Hagiwara²,

Ochi³

et al. 1991

Hum Genet

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The frequencies of chromosomal breaks and sister chromatid exchanges (SCE) are influenced by pregnancy, oral hormonal contraceptives and the menstrual cycle. The changes in the number and sites of spontaneous and aphidicolin-induced breaks on chromosomes from peripheral blood lymphocytes during the menstrual cycle were examined in 8 healthy women. Menstrual cycle was determined by menstruation and the quantity of serum estrogen, progesterone and luteinizing hormone. The number of spontaneous breaks at the follicular phase, the interval phase (which includes ovulation) and the luteal phase were 3.1 +/- 1.1, 2.7 +/- 2.3 and 3.9 +/- 2.6 per 100 mitoses, respectively. The frequencies of aphidicolin-induced breaks in the same phases were 95.8 +/- 23.3, 90.6 +/- 14.3 and 122.7 +/- 20.1 per 100 mitoses, respectively. The higher frequency at the luteal phase was statistically significant compared with the other phases. In the luteal phase, bands 2q32, 3q27, 6q26 and 16q23 had higher frequencies of breaks (P less than 0.05); however, breaks at band 9q32 decreased significantly. SCE showed considerable variation, but with no statistical significance.

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Section: Discussionmentioning

confidence: 99%

Changes of common fragile sites on chromosomes according to the menstrual cycle

Furuya

Hagiwara²,

Ochi³

et al. 1991

Hum Genet

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Neither age nor sex influence the expression of folate sensitive common fragile sites on human chromosomes

Smeets

Merkx

1990

Hum Genet

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The expression of folate sensitive common fragile sites was investigated in 82 normal healthy males and females of various ages. In 100 studied metaphases of each of these controls, between 0 and 56 lesions were detected (mean 18.3 +/- 10.3 SD). No significant difference was found between the mean number of expressed lesions in females and males. No age-effects were observed. Two "new" common fragile sites were discovered at 6p21 and 17q21. Their fragile site status, however, needs to be confirmed.

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Increased expression of 5q31 fragile site in a Bloom syndrome family

et al. 1992

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In this work, we report spontaneous chromosomal breakpoints and fragile site expression induced by 5-fluorodeoxyuridine (FdUrd) and FdUrd plus caffeine in a family with Bloom's syndrome (BS) and 2 healthy donors. Standard and G-banded metaphases from each individual and each treatment were analyzed. Among the 59 common fragile sites (c-fra) identified in this work, only the frequency of 5q31 was significantly increased in the BS family with respect to healthy donors (P less than 0.005). A remarkable coincidence between the breakpoints involved in spontaneous chromosome aberrations and induced c-fra was found in BS homozygote patients. The importance of the interaction between fragile sites and chromosome rearrangements in cancer is discussed.

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Familial and individual variation in chromosome fragility

Cited by 6 publications

References 28 publications

Changes of common fragile sites on chromosomes according to the menstrual cycle

Changes of common fragile sites on chromosomes according to the menstrual cycle

Neither age nor sex influence the expression of folate sensitive common fragile sites on human chromosomes

Increased expression of 5q31 fragile site in a Bloom syndrome family

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