Familial and second gastric carcinomas

Hemminki, Kari; Jiang, Yongwen

doi:10.1002/cncr.10322

Cited by 21 publications

(1 citation statement)

References 85 publications

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“…There have been attempts to explain gastric cancer’s nonspecific vascularization using modern techniques of molecular biology, vascular imaging, and estimation of the activity of chosen cytokines responsible for angiogenesis and the degradation of extracellular matrix. This is an important problem because any malignant tumor above 1mm, in order to survive, requires the proliferation of new blood vessels [1–3]. Angiogenesis in solid tumors is a complex process and plays an important role in the progression of the disease and in the metastatic process.…”

Section: Introductionmentioning

confidence: 99%

VEGF and metalloproteinase 2 (MMP 2) expression in gastric cancer tissue

Partyka

Gonciarz²,

Jałowiecki

et al. 2012

Med Sci Monit

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SummaryBackgroundNeoplasms are the second leading cause of death in Poland after vessel diseases, despite the huge progress in medical sciences in the last 20 years. Recently, gastric cancer morbidity has decreased, but mortality is still at a high level.Material/MethodsTissues from 24 patients with a histopathologically diagnosed mucosal and adenomucosal gastric cancer were tested. Patients were divided into 2 equal groups: patients without metastases (G1) and patients with metastases in the liver (G2). In all tested tissues of G1 and G2, the expression of VEGF (vascular endothelial growth factor) and metalloproteinase 2, respectively, were estimated.ResultsResults revealed a statistically significant increase in the VEGF expression for G1 and G2 in relation to the margin (p1<0.001; p2<0.001). The increase of gene expression for VEGF did not significantly differ statistically in G1 and G2. The obtained results revealed a statistically significant difference in the increase of gene expression for MMP-2 in G1 in relation to the margin (p<0.05) and a very high one in G2 in relation to the average margin value (p<0.001). A highly statistically significant correlation was obtained for VEGF and MMP-2 in the tissue of patients with metastases (p<0.001; r=0.714). The highly elevated expression of MMP-2 in the tissue of gastric cancer in patients with metastases confirms its participation in the invasiveness of the neoplasmatic process.ConclusionsThe highly significant correlation between VEGF and MMP-2 suggests a connection between both mechanisms in the progression of gastric cancer.

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Section: Introductionmentioning

confidence: 99%

VEGF and metalloproteinase 2 (MMP 2) expression in gastric cancer tissue

Partyka

Gonciarz²,

Jałowiecki

et al. 2012

Med Sci Monit

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Familial risk of cancer by site and histopathology

Hemminki

2002

Intl Journal of Cancer

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Familial risks for histopathology-specific cancers have not been determined. We used the nationwide Swedish FamilyCancer Database on 10.2 million individuals and 1 million tumors to calculate standardized incidence ratios (SIRs) for familial cancers of specific histology and morphology among 0-to 66-year-old offspring. We used histology codes for both offspring and parents, but because of the limited number of cases, the morphology-specific classification could be used only for offspring by all site-specific cancers in parents, resulting in inflated risk estimates. A number of novel findings emerged in the histopathology-specific analysis of familial risks, in addition to some known associations. Overall, specific histology showed an SIR of 2.07 for all cancers compared to an SIR of 2.00 for any histology. However, the small effect was due to breast and prostate cancers, which showed a negligible effect of specific histology. Familial risks of over 4.0 were found for serous papillary cystadenocarcinoma of the ovary, papillary thyroid cancer and low-grade astrocytoma. Familial risks of over 3.0 were found for signet-ring gastric cancer, various forms of ovarian cancer and squamous cell skin cancer. Also noteworthy were familial risks of hepatocellular carcinoma (2.48), pancreatic adenocarcinoma (1.92), large cell carcinoma and adenocarcinoma of the lung (2.29 and 2.18, respectively) and clear cell carcinoma of the kidney (2.73). Many of the findings were novel and could be revealed only by applying codes for specific histopathology. These data call for a closer description of familial aggregations and probing for the underlying genetic mechanisms.

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Familial risk of cancer: Data for clinical counseling and cancer genetics

Hemminki

Czene

2003

Intl Journal of Cancer

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103

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cancer and for multiple myeloma (3.33). When a sibling was affected, even prostate, renal, squamous cell skin, endocrine, gastric and lung cancer and leukemia showed SIRs in excess of 3.00. The highest cumulative risks were found for familial breast (5.5%) and prostate (4.2%) cancers. We identified reliable familial risks for 24 common neoplasms, most of which lack guidelines for clinical counseling or action level. If, for example, a familial SIR of 2.2 would be use as an action level, counseling would be needed for most cancers at some diagnostic age groups. The present data provide the basis for clinical counseling.

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Familial and second gastric carcinomas

Cited by 21 publications

References 85 publications

VEGF and metalloproteinase 2 (MMP 2) expression in gastric cancer tissue

VEGF and metalloproteinase 2 (MMP 2) expression in gastric cancer tissue

Familial risk of cancer by site and histopathology

Familial risk of cancer: Data for clinical counseling and cancer genetics

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