Familial association between type 1 diabetes and other autoimmune and related diseases

Hemminki, Kari; Li, Xinjun; Sundquist, Jan; Sundquist, Kristina

doi:10.1007/s00125-009-1427-3

Cited by 106 publications

(97 citation statements)

References 46 publications

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“…In accordance with previous observations, associated autoimmunity was common among our T1D patients, with thyroid autoimmunity most frequently detected, followed by CD [1,2,3,4,5,7,8,24]. Most associated AID appeared after diagnosis of T1D.…”

Section: Discussionsupporting

confidence: 72%

Coexistent Autoimmunity in Familial Type 1 Diabetes: Increased Susceptibility in Sib-Pairs?

Lebenthal

Yackobovitch‐Gavan²,

Vries³

et al. 2011

Horm Res Paediatr

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Background: Type 1 diabetes (T1D) patients are at risk for additional autoimmune diseases (AID). Objective: To compare the characteristics of associated autoimmunity among familial (parent-offspring and sib-pair) subgroups and sporadic T1D patients. Patients and Methods: Data regarding AID in T1D patients and their nuclear family members were extracted from medical files of 121 multiplex T1D families (58 parent-offspring, 63 sib-pairs) and 226 sporadic controls followed between 1979 and 2008. Results: The prevalence of associated autoimmunity was similar in familial and sporadic cases (33.6 vs. 32.7%). The frequency of additional AID and percentage of patients with two or more coexistent AID were significantly higher among sib-pairs than parent-offspring (p = 0.05 and p = 0.04, respectively). The median time elapsed between diagnosis of T1D and occurrence of additional autoimmunity tended to be shorter in the sib-pairs. Only in familial cases did a positive autoimmune family background predict the development of coexistent autoimmunity (OR = 2.11, CI [1.0, 4.49] p = 0.05). Conclusions: Among sib-pairs with T1D, the higher prevalence of additional AID, the increased number of diseases per person, and the relatively earlier appearance of associated AID suggest an increased susceptibility for coexistent autoimmunity in this subgroup. Positive family history for autoimmunity in multiplex T1D families increased their risk for co-occurrence of AID.

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Section: Discussionsupporting

confidence: 72%

Coexistent Autoimmunity in Familial Type 1 Diabetes: Increased Susceptibility in Sib-Pairs?

Lebenthal

Yackobovitch‐Gavan²,

Vries³

et al. 2011

Horm Res Paediatr

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“…The degree of hospitalization for the covered 34 diseases probably vary extensively depending on the seriousness of the condition and alternative forms of treatment, as we have discussed for some of the covered diseases elsewhere (17,(24)(25)(26). Another issue relating to the interpretation of the results is the change of SIRs depending on the definition of the follow-up time, as seen in Table 2.…”

Section: Discussionmentioning

confidence: 98%

Risk of asthma and autoimmune diseases and related conditions in patients hospitalized for obesity

Hemminki

Sundquist

et al. 2011

Annals of Medicine

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“…The aforementioned review cited 42.5% for rheumatoid arthritis as the only autoimmune disease [24]. We have discussed coverage in many of our previous papers on familial clustering of autoimmune diseases [25][26][27][28]. Severe debilitating conditions, such as Graves' disease, type 1 diabetes mellitus, Crohn's disease and ulcerative colitis lead to hospitalisation at one point or another in Sweden.…”

Section: Discussionmentioning

confidence: 99%

Effect of autoimmune diseases on risk and survival in histology-specific lung cancer

Hemminki

Liu

et al. 2012

Eur Respir J

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Patients with autoimmune diseases are at an increased risk of cancer due to underlying dysregulation of the immune system or treatment. Data on cancer incidence, mortality and survival after autoimmune diseases would provide further information on the clinical implications.We systematically analysed data on lung cancer in patients diagnosed with 33 different autoimmune diseases. Standardised incidence ratios (SIRs), standardised mortality ratios (SMRs) and hazard ratios (HRs) were calculated for subsequent incident lung cancers or lung cancer deaths up to 2008 in patients hospitalised for autoimmune disease after 1964.Increased risks of lung cancer were recorded for SIRs after 12 autoimmune diseases, SMRs after 11 autoimmune diseases and HRs after two autoimmune diseases. The highest SIRs and SMRs, respectively, were seen after discoid lupus erythematosus (4.71 and 4.80), polymyosistis/ dermatomyositis (4.20 and 4.17), systemic lupus erythematosus (2.47 and 2.69), rheumatic fever (2.07 and 2.07) and systemic sclerosis (2.19 and 1.98). Autoimmune disease did not influence survival overall but some autoimmune diseases appeared to impair survival in small cell carcinoma.All autoimmune diseases that had an SIR .2.0 are known to present with lung manifestations, suggesting that the autoimmune process contributes to lung cancer susceptibility. The data on survival are reassuring that autoimmune diseases do not influence prognosis in lung cancer.

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Familial association between type 1 diabetes and other autoimmune and related diseases

Cited by 106 publications

References 46 publications

Coexistent Autoimmunity in Familial Type 1 Diabetes: Increased Susceptibility in Sib-Pairs?

Coexistent Autoimmunity in Familial Type 1 Diabetes: Increased Susceptibility in Sib-Pairs?

Risk of asthma and autoimmune diseases and related conditions in patients hospitalized for obesity

Effect of autoimmune diseases on risk and survival in histology-specific lung cancer

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