Familial Auricular Fibrillation

Wolff, Louis

doi:10.1056/nejm194309022291002

Cited by 151 publications

(55 citation statements)

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“…This condition is called lone AF. Some of these patients have a positive family history for AF and may have a genetic cause or predisposition [14,15]. Familial cases of AF, however, are rare, and the identified genetic defects in rare families may not represent the molecular basis of the more common sporadic cases in the healthy heart [16].…”

Section: Discussionmentioning

confidence: 99%

The Single Nucleotide Polymorphisms of Kir3.4 Gene and Their Correlation with Lone Paroxysmal Atrial Fibrillation in Chinese Han Population

Zhang

Yuan

Cheng

et al. 2009

Heart, Lung and Circulation

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Section: Discussionmentioning

confidence: 99%

The Single Nucleotide Polymorphisms of Kir3.4 Gene and Their Correlation with Lone Paroxysmal Atrial Fibrillation in Chinese Han Population

Zhang

Yuan

Cheng

et al. 2009

Heart, Lung and Circulation

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“…While the exact nature of any predisposition to AF remains unclear, in some instances such a diathesis may be inherited. There are isolated reports of families with AF dating from Wolff's original description in 1943 (Wolff 1943), and recently several groups have identified multigenerational kindreds with lone AF (Bertram et al 1996;Poret et al 1996). Genetic loci have been identified on chromosomes 10q22 and 6q14-16 (Brugada et al 1997;Ellinor et al 2003).…”

Section: Introductionmentioning

confidence: 99%

Familial aggregation in lone atrial fibrillation

et al. 2005

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Atrial fibrillation (AF) is the most common clinical arrhythmia and a major risk factor for stroke. To investigate the role of genetic factors in a typical clinical population, we determined the extent of familial aggregation in patients with lone AF. To estimate the relative risk to family members, the prevalence of AF for each class of relative was compared to the prevalence in the comparable age and sex group from the general population. Family members had an increased relative risk of AF compared to the general population (risk ratio; 95% confidence intervals): sons (8.1; 2.0-32), daughters (9.5; 1.3-67), brothers (70; 47-102), sisters (34; 14-80), mothers (4.0; 2.5-6.5) and fathers (2.0; 1.2-3.6). Relatives of probands with lone AF are at a substantially increased risk of developing this arrhythmia suggesting a Mendelian genetic contribution to the etiology of this common trait.

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“…Over the last ten years, a preponderance of evidence also suggests a large genetic contribution to AF. The earliest report of familial AF dates to the early 1940s 1 . Since then, it has become apparent that AF in referral populations 2,3 and in the community is heritable 4,5 .…”

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confidence: 99%

Emerging Directions in the Genetics of Atrial Fibrillation

Tucker

Ellinor

2014

Circulation Research

114

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Atrial fibrillation (AF) is the most common arrhythmic disorder, and currently affects nearly 3 million Americans, 8.8 million Europeans, and an estimated 30 million individuals worldwide. The clinical risk factors for AF are numerous, with age, sex, hypertension, obesity, and ischemic heart disease among the most prevalent. Over the last ten years, a preponderance of evidence also suggests a large genetic contribution to AF. The earliest report of familial AF dates to the early 1940s1. Since then, it has become apparent that AF in referral populations2,3 and in the community is heritable4,5. Indeed, having a family member with AF is associated with a 40% increased risk for the arrhythmia6. Once the heritability was recognized, traditional genetics techniques for the discovery of rare, monogenic causes of AF were used to identify the initial AF genes. These studies in turn, informed candidate gene screening in AF cohorts. To identify additional sources of heritability for AF, large-scale analyses of common variation through genome wide association studies (GWAS) has recently yielded data identifying risk loci in many regions of the genome. In spite of these advances, the combination of these techniques has, as yet, failed to completely identify the heritability of AF in the population. It is the goal of this review to examine the previous studies on rare variants, address the findings of the recent GWAS studies, and describe future avenues towards defining the heritability of AF.

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Familial Auricular Fibrillation

Cited by 151 publications

References 0 publications

The Single Nucleotide Polymorphisms of Kir3.4 Gene and Their Correlation with Lone Paroxysmal Atrial Fibrillation in Chinese Han Population

The Single Nucleotide Polymorphisms of Kir3.4 Gene and Their Correlation with Lone Paroxysmal Atrial Fibrillation in Chinese Han Population

Familial aggregation in lone atrial fibrillation

Emerging Directions in the Genetics of Atrial Fibrillation

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