Familial cancers associated with subtypes of leukemia and non-hodgkin's lymphoma

Epidemiology and ethnic aspects of B cell chronic lymphocytic leukemia in Israel

“…The relative importance of environmental exposure vs inherited predisposition to CLL remains to be determined. Familial aggregation of cases in first-degree relatives of CLL patients has occasionally been reported 23,24 suggesting an impact of genetic factors on the disease development. Iscovich and Parkin 25 reported an analysis on the risk of lymphomas and leukemias in the population under 30 years old in Israel, which has a low CLL incidence in this age.…”

The non-Hodgkin lymphomas: A review of the epidemiologic literature

“…148 A weaker, nonsignificant association was reported among t(14;18)-positive NHL cases (OR 5 1.3, 95% CI: 0.5-3.3). 148 Pottern et al 480 evaluated NHL in white males with a family history of HLP cancers and other cancers, and found that having at least one relative with HLP increased the risk of NHL. The association with having a sibling with HLP (OR 5 2.7, 95% CI: 1.5-5.1) was stronger than that with having at least one parent with HLP (OR 5 1.5, 95% CI: 0.8-2.8).…”

CLL family ‘Pedigree 14’ revisited: 1947–2004

“…The overrepresentation of breast cancer in the family and the increased risk of this tumour in relatives of CLL cases observed in epidemiological studies 8,9 raises the possibility that predisposition to CLL may involve disruption of genes encoding components of the BRAC1-BRAC2-ATM axis involved in the repair of DNA damage and fidelity of homlogous recombination. To date, there is, however, no evidence that germline mutations in either BRCA1 or BRCA2 confer an increased risk of CLL.…”