Familial clustering of hepatitis C virus in a Pakistani population

Jamil, Zubia; Waheed, Yasir; Ahsan, Omar; Najmi, Muzammil Hasan; Yousuf, Hamid

doi:10.1002/jmv.25926

Cited by 9 publications

(4 citation statements)

References 23 publications

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“…Among the 1961 initially identified studies, 71 were included in the review and meta‐analysis, 21–91 as described in the flow diagram (Figure 1). The total number of participants across all selected studies was 120,568.…”

Section: Resultsmentioning

confidence: 99%

Meta‐analysis: risk of hepatitis C virus infection associated with hospital‐based invasive procedures

Henriot

Castry

Ngũyen

et al. 2022

Aliment Pharmacol Ther

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Summary Background Healthcare settings, where invasive procedures are frequently performed, may play an important role in the transmission dynamics of blood‐borne pathogens when compliance with infection control precautions is suboptimal. Aims To understand and quantify the role of hospital‐based invasive procedures on hepatitis C virus (HCV) transmission. Methods We conducted a systematic review and meta‐analysis to identify recent studies reporting association measures of HCV infection risk that are linked to iatrogenic procedures. Based on expert opinion, invasive procedures were categorised into 10 groups for which pooled measures were calculated. Finally, the relationship between pooled measures and the country‐level HCV prevalence or the Healthcare Access and Quality (HAQ) index was assessed by meta‐regression. Results We included 71 studies in the analysis. The most frequently evaluated procedures were blood transfusion (66 measures) and surgery (43 measures). The pooled odds ratio (OR) of HCV infection varied widely, ranging from 1.46 (95% confidence interval: 1.14–1.88) for dental procedures to 3.22 (1.7–6.11) for transplantation. The OR for blood transfusion was higher for transfusions performed before 1998 (3.77, 2.42–5.88) than for those without a specified/recent date (2.20, 1.77–2.75). In procedure‐specific analyses, the HCV infection risk was significantly negatively associated with the HAQ for endoscopy and positively associated with HCV prevalence for endoscopy and surgery. Conclusions Various invasive procedures were significantly associated with HCV infection. Our results provide a ranking of procedures in terms of HCV risk that may be used for prioritisation of infection control interventions, especially in high HCV prevalence settings.

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Section: Resultsmentioning

confidence: 99%

Meta‐analysis: risk of hepatitis C virus infection associated with hospital‐based invasive procedures

Henriot

Castry

Ngũyen

et al. 2022

Aliment Pharmacol Ther

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“…The study shows and serves to substantiate the claim that the most common type of viral hepatitis in Pakistan is still Hepatitis C by far and large [8] . The other types are more in percentage in the general healthy population as acute cases of non-HCV hepatitis rarely admit into the hospital without cause for concern.…”

Section: Discussionmentioning

confidence: 52%

A Kap Study of Hepatitis Among Hepatitis Positive Patients Presenting to a Tertiary Care Hospital in Southern Punjab, Pakistan

Anjum¹,

Maik²,

Rizwan³

et al. 2022

PJMHS

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Objective: To study prevalence and assessment of knowledge, attitude, and practice regarding hepatitis in patients presenting to a tertiary care hospital in Southern Punjab. Method: The study was conducted at the medicine wards of Sheikh Zayed medical hospital, Rahim Yar Khan for three months from July till September 2021. The data was collected through a physical questionnaire which was divided into three sections relating to prevalence, prevention along with control and risk factors. The collected data was then analysed using SPSS version 26. Results: Out of 219 patients, there were 83 females (38.42%) and 133 males (61.57%). The mean age of the population was found to be 51.74 (15.51). Hepatitis C (86.1%) was found in the highest prevalence. 128 patients (59.2%) were chronic cases while 88 (40.7%) were acute. Regarding co-morbidities, 32.9% patients had diabetes type II (DM-II) and 31.5% of the patients had pre-existing primary hypertension (HTN). In terms of awareness, it was found that 122 (56.5%) attendants/patients were able to correlate their presenting symptoms with hepatitis. 129 (59.7%) of attendants showed some understanding about vaccination. Only the association between the attitude score among males and females was found to be statistically significant (p-value= .003). Conclusion: Despite increasing vaccination trends, hepatitis cases are still prevalent as the most common cause is HCV which has no vaccination. Good prognosis of HCV requires early detection which is rare as the public still lacks knowledge on its disease course and a proactive attitude. Keywords: KAP, Hepatitis C, Pakistan, South Punjab, Hepatitis B, Hepatitis Vaccination, Awareness, Vertical transmission, Hepatitis

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“…This discrepancy among various studies in the incidence of transmission between different family members is attributed to the discrepancy in the duration of contact with those positive contacts regardless of kinship. Evidently, the longer the duration of contact with an HCV-infected relative, the higher the risk of transmission (20,21) . In our study, the incidence of HCV infection was significantly higher among patients who performed the following activities: sharing shaving machines and sugar measurement device with HCV-infected family members, sharing towels with family members, and Handshaking/kissing HCV-infected relatives.…”

Section: Discussionmentioning

confidence: 99%

Intrafamilial Transmission of Hepatitis C Virus among Household Members of Hepatitis C Virus Patients

Tolba

Hassan

Sheded

et al. 2020

Suez Canal University Medical Journal

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Background: Egypt is considered one of the highly endemic countries with Hepatitis C Virus (HCV) infection. Since we are moving into the HCV-free era, it is necessary to acknowledge the most common methods of HCV transmission. Intrafamilial transmission is one important method that hugely contributed to that endemicity. Aim: Our aim is to identify the prevalence of intrafamilial transmission of HCV among household contacts of chronic HCV patients, risk factors, and methods of transmission. Subjects and Methods: In this study, we recruited 807 Household members of 228 chronic HCV patients. Eligible participants were subjected to history taking, clinical examination, and blood testing for HCV antibodies and PCR. Results: We found that HCV infection was more prevalent among older age groups; married; who live in rural residence; and having high crowding index. Among relatives with HCV, parents were the most affected, followed by siblings, then husbands or wives. The longer the duration of contact, the higher the risk of infection. The incidence of HCV infection was significantly higher among patients who did the following activities: Sharing shaving machine and sugar measurement device with HCVinfected family members, sharing towels with family members, and Handshaking/kissing HCVinfected relatives. Conclusions: Intrafamilial transmission of HCV is an undeniable risk factor, which amplified the burden of HCV. Recognition of remarkable modes of intrafamilial transmission would facilitate suppression of infectivity, as a result achieving the ambition of an HCV-free Egypt.

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Familial clustering of hepatitis C virus in a Pakistani population

Cited by 9 publications

References 23 publications

Meta‐analysis: risk of hepatitis C virus infection associated with hospital‐based invasive procedures

Meta‐analysis: risk of hepatitis C virus infection associated with hospital‐based invasive procedures

A Kap Study of Hepatitis Among Hepatitis Positive Patients Presenting to a Tertiary Care Hospital in Southern Punjab, Pakistan

Intrafamilial Transmission of Hepatitis C Virus among Household Members of Hepatitis C Virus Patients

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