Familial frontal fibrosing alopecia

Dlova, Ncoza C.; Cl, Goh; Tosti, Antonella

doi:10.1111/j.1365-2133.2012.11101.x

Cited by 62 publications

(72 citation statements)

References 13 publications

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“…Various hypotheses exist including environmental and genetic factors. 88 The management of LPP and its variants includes the use of topical and intralesional corticosteroids, and/or oral systemic agents such as corticosteroids, hydroxychloroquine, doxycycline, mycophenolate mofetil and ciclosporin. 82 Folliculitis keloidalis nuchae FKN (Fig.…”

Section: Lichen Planopilaris and Frontal Fibrosing Alopeciamentioning

confidence: 99%

Hair and scalp disorders in women of African descent: an overview

2013

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Section: Lichen Planopilaris and Frontal Fibrosing Alopeciamentioning

confidence: 99%

Hair and scalp disorders in women of African descent: an overview

2013

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“…Environmental toxins resembling dioxinlike provides, prompt AhR that is known to suppress PPAR-gamma [28]. The position of PPAR-gamma and AhR in FFA stay to be elucidated ( Figure 5) [26]. The possible position of environmental factors in FFA is supported through alternative observations.…”

Section: Introductionmentioning

confidence: 98%

“…Given these observations, there could also be prodigious interest within the aetiologies of FFA and therefore the manner this may justify why we tend to are apparently seeing increasing numbers of instances. On account that the primary case studies of FFA affecting siblings, [23][24][25] there had been an increasing quantity of studies of familial cases [26,27], suggesting a potential genetic predisposition and reviews are a foot to envision dead set establish genes which can be related to FFA. Nonetheless, genetic susceptibility on my own would no longer give an explanation for the apparent expand in FFA incidence.…”

Section: Introductionmentioning

confidence: 99%

“…Nonetheless, genetic susceptibility on my own would no longer give an explanation for the apparent expand in FFA incidence. It has been planned that clusters of affected cases at intervals families could indicate not solely genetic susceptibleness however viable environmental triggers [26] Karnik et al [28] released experimental proof that tested a possible position for peroxisome proliferator activated receptor-gamma (PPAR-gamma) in pathologic process of LPP. They established that PPAR-gamma, a transcription issue that belongs to the nuclear receptor tremendous-gene worshipped ones, is needed for preservation of cyst stem cells and valid that mice with PPAR-gamma deleted from cyst stem cells developed a scarring phalacrosis.…”

Section: Introductionmentioning

confidence: 99%

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Frontal Fibrosing Alopecia

Holmes¹

2017

Pigmentary Disorders

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Frontal fibrosing alopecia, described simply over two decades in the past, has come to be probably the most normally noticeable causes of scarring phalacrosis at several skilled hair clinics. Regarded a medical variant of lichen planopilaris (LPP), its uncommon components and associations that distinguish it from LPP. Despite the fact that largely affecting post-menopausal ladies, a small however growing number of guys and premenopausal ladies are affected. The spectrum of the ailment has accelerated from involvement of the frontal hairline and eyebrows, to potentially affecting the whole hairline, facial and body hair. Genetic and environmental motives were implicated however the aetiology remains uncertain. A range of cures had been used in management of the, however medical trials are required to set up effectiveness.

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“…Familial cases of FFA point to the possible contribution of hereditary factors, possibly related to androgenetic alopecia [5,6,7], while recent questionnaire-based studies performed in patients with FFA suggest environmental factors, namely a possible association between FFA and the use of facial skin care products, particularly sunscreens [8,9]. The causality of this relationship remains to be confirmed since the study may have been biased through patient and question selection as well as confounding factors that were not included in the questionnaires.…”

Section: Introductionmentioning

confidence: 99%

Cutaneous Lupus Erythematosus Presenting as Frontal Fibrosing Alopecia: Report of 2 Patients

Trüeb

Shabrawi‐Caelen

Kempf³

2017

Skin Appendage Disord

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Frontal fibrosing alopecia represents a peculiar condition with a quasi-symmetrical, marginal scarring alopecia along the frontal and temporal hairline. The condition has been associated with further histopathologic and/or clinical evidence of lichen planopilaris. Since its emergence with the original report of Kossard in 1994, frontal fibrosing alopecia has been recognized to be associated with a number of comorbidities, including lupus erythematosus. So far, respective case reports and case series have given account of frontal fibrosing alopecia with the histopathologic features of lichen planopilaris associated or overlapping with lupus erythematosus. In contrast, we present cases of histopathologically proven cutaneous lupus erythematosus presenting as frontal fibrosing alopecia with a good response to the respective treatment with oral hydroxychloroquine and/or intralesional triamcinolone acetonide.

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Familial frontal fibrosing alopecia

Cited by 62 publications

References 13 publications

Hair and scalp disorders in women of African descent: an overview

Hair and scalp disorders in women of African descent: an overview

Frontal Fibrosing Alopecia

Cutaneous Lupus Erythematosus Presenting as Frontal Fibrosing Alopecia: Report of 2 Patients

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