Familial history of diabetes and clinical characteristics in Greek subjects with type 2 diabetes

Papazafiropoulou, Athanasia; Sotiropoulos, Alexios; Skliros, Eystathios; Kardara, Marina; Kokolaki, Anthi; Apostolou, Ourania; Pappas, Stavros

doi:10.1186/1472-6823-9-12

Cited by 44 publications

(48 citation statements)

References 37 publications

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“…In contrast, the Greek study on type 2 DM patients showed a reduced HbA1c level in patients with coexisting hypothyroidism (7.38% compared to 7.81%) although this was statistically insignificant. [9] The same observation was made by Kim et al in Taiwan, with a mean HbA1c of 8.8% and 8.4% in euthyroid and hypothyroid diabetic individuals respectively. [10] The variations in the above observations and the absence of any significant findings is probably due to the multiple mechanisms by which hypothyroidism can decrease as well as increase the blood glucose values.…”

Section: Discussionsupporting

confidence: 63%

Subclinical Hypothyroidism in Type 2 Diabetes Mellitus: Prevalence and Effects on Glycaemic and Lipid Profile

S¹,

Dhanasekaran²

2017

jemds

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BACKGROUNDThere is a significant prevalence of thyroid disorders in patients with diabetes mellitus, the most common being subclinical hypothyroidism. The coexistence of subclinical hypothyroidism in diabetes may alter the glycaemic profile and lipid profile that is expected in these patients Objectives-To determine the prevalence of subclinical hypothyroidism in patients with type 2 diabetes mellitus and to evaluate glycaemic profile and lipid profile in patients having both the disorders.

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Section: Discussionsupporting

confidence: 63%

Subclinical Hypothyroidism in Type 2 Diabetes Mellitus: Prevalence and Effects on Glycaemic and Lipid Profile

S¹,

Dhanasekaran²

2017

jemds

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“…Em nosso estudo, apenas 3% das pacientes com DMG não teriam sido investigadas se tivessem sido adotados os critérios de rastreamento seletivo recomendados pela American Diabetes Association (ADA) A história familiar de diabetes tipo 2 é considerada um forte fator de risco para DMG, com relato de aumento de 68% no risco para a doença na presença desse fator (19). Além disso, diversos estudos têm demonstrado uma grande prevalência de diabetes materno em pacientes com diabetes tipo 2 em diferentes populações (20,21). Bo e cols., analisando a prevalência de história Tabela 9.…”

Section: Discussionunclassified

Marcadores para o diagnóstico e tratamento de 924 gestações com diabetes melito gestacional

Detsch

Almeida

Bortolini

et al. 2011

Arq Bras Endocrinol Metab

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RESUMOObjetivos: Avaliar o perfil epidemiológico e a evolução de mulheres com diabetes melito gestacional (DMG), determinando fatores de risco para maior vigilância. Sujeitos e métodos: Foram estudadas 924 gestações de 916 pacientes, de 6 de novembro de 2001 a 21 de setembro de 2009. Resultados: Foram encontrados fatores de risco para DMG em 95,1% dos casos. A prevalência de diabetes materno, paterno e em outros familiares foi de 24,3%, 9,4% e 24,7%, respectivamente. Os fatores preditivos para uso de insulina foram: glicemia de jejum (GJ) no rastreamento ≥ 85, GJ no Teste Oral de Tolerância à Glicose (TOTG) ≥ 95, glicemia 2h após 75 g de glicose ≥ 200 mg/dL, DMG prévio, obesidade, HbA1c > 6% e história familiar de DM em parente de primeiro grau associada à obesidade ou DMG prévio, esta última a associação mais relevante (p < 0,05). Conclusões: Os fatores de risco analisados se mostraram altamente sensíveis para a detecção de DMG, e a disposição da história familiar reforça sua relação com o DM2. Recomenda-se maior vigilância a gestantes com fatores preditivos para necessidade de insulina. Arq Bras Endocrinol Metab. 2011;55(6):389-98 Descritores Diabetes gestacional; fatores de risco; controle metabólico; tratamento; insulina; complicações ABSTRACT Objectives: To evaluate the epidemiological profile and outcomes of women with gestational diabetes mellitus (GDM), determining risk factors for increased vigilance. Subjects and methods: We studied 924 pregnancies in 916 patients between November 6, 2001 and September 21, 2009. Results: Risk factors were found in 95.1% of cases. The prevalence of maternal diabetes, paternal diabetes and diabetes in other family members was 24.3%, 9.4% and 24.7%, respectively. Predictive factors for insulin use were: screening fasting glucose (FG) ≥ 85, Oral Glucose Tolerance Test (OGTT) FG ≥ 95, 2h glucose after 75 g ≥ 200 mg/dL, previous GDM, obesity, HbA1c > 6%, and the association of risk factors including family history of diabetes mellitus and obesity or previous GDM, the last one the most relevant (p < 0,05). Conclusions: Risk factors were very sensitive for GDM detection, and provision of family history strengthens its relationship with T2DM. Greater vigilance is recommended for patients with predictive factors for insulin requirement. Arq Bras Endocrinol Metab. 2011;55(6):389-98

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“…For example, absence of excess of maternal transmission was observed in South Indian [10] as well as in Korean population with T2DM [11], supported later by a study on Western Indian population [12]. It was suggested that parental T2DM was an independent risk factor for offspring of T2DM in Korean population Kim et al On the other hand, in recent years presence of excess maternal transmission of T2DM has been documented in Greek diabetics [13], supporting previous studies in Brazil [14], and Norway [15]. A very recent finding by Abbasi et al on population of Netherland showed that both maternal and paternal diabetes seem to be associated with increased risk of T2DM, independently of diet, lifestyle and obesity [16].…”

Section: Introductionmentioning

confidence: 63%

“…McCarthy et al in contrast did not find any difference of transmission of diabetes in their population [27], but in several studies maternal transmission was found in different populations [13,14,[28][29][30].…”

Section: Discussionmentioning

confidence: 99%

Maternal and Paternal Transmission of Diabetes: Influence of Nutritional Factors

Rahim

Rahim²,

Rahim³

et al. 2016

J Diabetes Metab

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Familial history of diabetes and clinical characteristics in Greek subjects with type 2 diabetes

Cited by 44 publications

References 37 publications

Subclinical Hypothyroidism in Type 2 Diabetes Mellitus: Prevalence and Effects on Glycaemic and Lipid Profile

Subclinical Hypothyroidism in Type 2 Diabetes Mellitus: Prevalence and Effects on Glycaemic and Lipid Profile

Marcadores para o diagnóstico e tratamento de 924 gestações com diabetes melito gestacional

Maternal and Paternal Transmission of Diabetes: Influence of Nutritional Factors

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