Familial history of esophageal cancer

Ghadirian, Parviz

doi:10.1002/1097-0142(19851015)56:8<2112::aid-cncr2820560838>3.0.co;2-3

Cited by 40 publications

(21 citation statements)

References 7 publications

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“…Foulkes et al (1995) also reported the similar OR of 3.65 for head-and-neck cancer in those with a family history of this cancer. Regarding esophageal cancer, some epidemiological surveys have revealed a strong family aggregation, especially in areas with high incidence, such as China (Li et al, 1989) and Iran (Ghadirian, 1985). In the current study, the OR for PhCe cancer increased in cases with a family history of the UADT cancers.…”

Section: Discussionsupporting

confidence: 49%

Family aggregation of carcinoma of the hypopharynx and cervical esophagus: Special reference to multiplicity of cancer in upper aerodigestive tract

et al. 1998

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Section: Discussionsupporting

confidence: 49%

Family aggregation of carcinoma of the hypopharynx and cervical esophagus: Special reference to multiplicity of cancer in upper aerodigestive tract

et al. 1998

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“…The Turkmen are genetically homogenous and are well suited for genetic studies of esophageal squamous cell carcinoma (ESCC). In addition to several proposed environmental factors, a number of studies have reported clustering of the disease in families (Pour and Ghadirian, 1974;Ghadirian, 1985). Recently, we reported a strong familial component to ESCC among Turkmen (Akbari et al, 2006).…”

mentioning

confidence: 73%

Germline BRCA2 mutations and the risk of esophageal squamous cell carcinoma

et al. 2007

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The incidence of esophageal squamous cell carcinoma (ESCC) is very high among the Turkmen population of Iran. Family studies suggest a genetic component to the disease. Turkmen are ethnically homogenous and are well suited for genetic studies. A previous study from China suggested that BRCA2 might play a role in the etiology of ESCC. We screened for mutations in the coding region of the BRCA2 gene in the germline DNA of 197 Turkmen patients with ESCC. A nonsense variant, K3326X, was identified in 9 of 197 cases (4.6%) vs 2 of 254 controls (0.8%) (OR ¼ 6.0, 95% CI ¼ 1.3-28; P ¼ 0.01). This mutation leads to the loss of the C-terminal domain of the BRCA2 protein, a part of the region of interaction with the FANCD2 protein. We observed nine other BRCA2 variants in single cases only, including two deletions, and seven missense mutations. Six of these were judged to be pathogenic. In total, a suspicious deleterious BRCA2 variant was identified in 15 of 197 ESCC cases (7.6%).

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“…Several epidemiological studies from high-risk areas in China and the Caspian Littoral of Iran found that esophageal/ gastric cancer aggregates in families, and that a family history of esophageal/gastric cancer is a risk factor for the disease (4)(5)(6)(7)(8)(9)(10)(11). Results have been less consistent in studies from other areas of the world.…”

Section: Introductionmentioning

confidence: 99%

Family History of Cancer, Its Combination with Smoking and Drinking, and Risk of Squamous Cell Carcinoma of the Esophagus

Garavello

Negri

Talamini

et al. 2005

Cancer Epidemiology, Biomarkers &Amp; Prevention

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We analyzed the association between history of cancer in first-degree relatives and the risk of squamous cell carcinoma of the esophagus (SCCE) using data from three case-control studies conducted in Italy and Switzerland on 805 incident, histologically confirmed SCCE, and 3,461 hospital controls. The alcohol-and tobacco-adjusted odds ratio (OR) for a family history of esophageal cancer was 3.2 [95% confidence interval (CI), 1.7-6.2], and the OR was higher when the affected relative was a brother or was diagnosed at age <55 years. Compared to subjects without family history of esophageal cancer, noncurrent smokers, drinking <49 drinks per week, the OR was 2.9 (95% CI, 1.1-7.5) for family history alone, 15.5 (95% CI, 11.7-20.5) for current smokers drinking z49 drinks per week without family history of esophageal cancer, and 107.0 (95% CI, 13.0-880.2) for current smokers drinking z49 drinks per week who also had a family history of esophageal cancer. The risk of SCCE was also increased in subjects with a family history of cancer of the oral cavity/pharynx (OR, 3.7; 95% CI, 1.5-9.0) and stomach (OR, 2.0; 95% CI, 1.1-3.6), but not of other cancers, nor for a family history of any cancer (OR, 1.0; 95% CI, 0.8-1.4). These data show that, as for many other epithelial cancers, the risk of SCCE is increased in subjects with a family history of the disease, and that-in Western countries-avoidance of alcohol and tobacco is also the best way to prevent SCCE in subjects with a family history of the disease.

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Familial history of esophageal cancer

Cited by 40 publications

References 7 publications

Family aggregation of carcinoma of the hypopharynx and cervical esophagus: Special reference to multiplicity of cancer in upper aerodigestive tract

Family aggregation of carcinoma of the hypopharynx and cervical esophagus: Special reference to multiplicity of cancer in upper aerodigestive tract

Germline BRCA2 mutations and the risk of esophageal squamous cell carcinoma

Family History of Cancer, Its Combination with Smoking and Drinking, and Risk of Squamous Cell Carcinoma of the Esophagus

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