Familial Hypercholesterolaemia as a Predisposing Factor for Atherosclerosis

Poznyak, Anastasia V.; Litvinova, L. S.; Poggio, Paolo; Orekhov, Alexander N.; Melnichenko, Alexandra А.

doi:10.3390/biomedicines10102639

Cited by 4 publications

(1 citation statement)

References 63 publications

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“…Intestinal bacteria play an important role in regulating metabolism and inflammation in the body. There may also be a close association between intestinal bacteria and the development of coronary atherosclerosis because atherosclerosis is both a metabolic disorder and a chronic inflammatory disorder ( Nazarian-Samani, Sewell & Rafieian-Kopaei, 2020 ; Poznyak et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Characterization of gut microbiota in adults with coronary atherosclerosis

Dong

Chen

et al. 2023

PeerJ

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Background Cardiovascular disease, which is mainly caused by coronary atherosclerosis, is one of the leading causes of death and disability worldwide. Gut microbiota likely play an important role in coronary atherosclerosis. This study aims to investigate the microbiota profile of adults with coronary atherosclerosis to provide a theoretical basis for future research. Methods Fecal samples were collected from 35 adult patients diagnosed with coronary atherosclerosis and 32 healthy adults in Nanjing, China, and the V3-V4 region of 16S rDNA genes was sequenced using high-throughput sequencing. Differences in alpha diversity, beta diversity, and gut microbiota composition between the two groups were then compared. Results A beta diversity analysis revealed significant differences between adults with coronary atherosclerosis and controls, but there was no statistical difference in alpha diversity between the two groups. There were also differences in the composition of the gut microbiota between the two groups. The genera, Megamonas, Streptococcus, Veillonella, Ruminococcus_torques_group, Prevotella_2, Tyzzerella_4, were identified as potential biomarkers for coronary atherosclerosis. Conclusion There are some differences in the gut microbiota of adults with coronary atherosclerosis compared to healthy adults. The insights from this study could be used to explore microbiome-based mechanisms for coronary atherosclerosis.

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Section: Introductionmentioning

confidence: 99%

Characterization of gut microbiota in adults with coronary atherosclerosis

Dong

Chen

et al. 2023

PeerJ

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Gastrodia elata Blume: A review of its mechanisms and functions on cardiovascular systems

et al. 2023

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Prevalence of genetically diagnosed familial hypercholesterolemia in Vietnamese patients with premature acute myocardial infarction

Nguyen,

Hoang

2024

Medicine

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Familial hypercholesterolemia (FH) is a genetic disorder that results in elevated low-density lipoprotein cholesterol (LDL-C) levels, which manifest early in the first decades of life. It is a major cause of premature coronary artery disease worldwide, leading to significant public health challenges. The prevalence of genetically determined FH in patients with premature coronary artery disease remains underestimated, particularly in developing countries. This study aimed to assess the prevalence of genetically defined FH in Vietnamese patients with premature acute myocardial infarction (AMI) in the Vietnamese population. This cross-sectional study enrolled 218 consecutive patients diagnosed with premature AMI who underwent coronary angiography. The low-density lipoprotein receptor (LDLR), apolipoprotein B, and proprotein convertase subtilisin-kexin type 9 genes were analyzed by next-generation sequencing. FH was diagnosed according to Dutch Lipid Clinic Network criteria. Among the patients with premature AMI who underwent coronary angiography, the mean age was 46.9 ± 6.1 years, with a predominance of males (83.9%). The prevalence of potential FH diagnosed using Dutch Lipid Clinic Network criteria was 14.7% (definite FH, 6.0%; probable FH, 8.7%). Pathogenic or likely pathogenic variants in LDLR, apolipoprotein B, and proprotein convertase subtilisin-kexin type 9 were found in 9 of 218 patients (4.1%), all of which were causative mutations in LDLR. Patients with premature AMI and FH had significantly greater LDL-C levels (217.6 vs 125.7 mg/dL) and more severe coronary artery lesions, as assessed by the Gensini score (100.3 vs 60.5), than did those in the No FH group. The prevalence of genetically determined FH among Vietnamese patients with premature AMI is relatively high. Screening and diagnosis of hereditary conditions in patients with premature AMI are essential to improve early detection and management and reduce the burden of coronary artery disease in this population.

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Familial Hypercholesterolaemia as a Predisposing Factor for Atherosclerosis

Cited by 4 publications

References 63 publications

Characterization of gut microbiota in adults with coronary atherosclerosis

Characterization of gut microbiota in adults with coronary atherosclerosis

Gastrodia elata Blume: A review of its mechanisms and functions on cardiovascular systems

Prevalence of genetically diagnosed familial hypercholesterolemia in Vietnamese patients with premature acute myocardial infarction

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