Familial incidence of cerebral aneurysms.

Chakravorty, B; Gleadhill, Colin A.

doi:10.1136/bmj.1.5480.147

Cited by 20 publications

(4 citation statements)

References 4 publications

(1 reference statement)

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“…In these reports familial SAH is loosely defined as the occurrence of SAH in 2 or more relatives, irrespective of the degree of kin [l}. Moreover, with the exception of two retrospective studies 13, 41, clinical characteristics have always been compared with those of series of patients with SAH from which familial SAH patients were not excluded, though these comprise 5 to 10% of all cases 13-51. The imprecise definition and the presence of familial SAH patients in the control groups may have obscured differences between familial and sporadic SAH. A difference in the biological features is, however, suggested by our recent finding that familial SAH carries a worse prognosis than does sporadic SAH {GI.…”

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confidence: 99%

Familial subarachnoid hemorrhage: Distinctive features and patterns of inheritance

Bromberg

Rinkel

Algra

et al. 1995

Annals of Neurology

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To delineate the distinctive features of familial subarachnoid hemorrhage, we compared gender and age at the time of subarachnoid hemorrhage, as well as site and number of aneurysms, in patients with familial subarachnoid hemorrhage (at least 1 first-degree relative with subarachnoid hemorrhage) and patients with sporadic subarachnoid hemorrhage (no subarachnoid hemorrhage in first- or second-degree relatives), in a prospective, hospital-based series of patients. In addition we studied the pattern of inheritance in 17 families with familial subarachnoid hemorrhage. Mean age at the time of hemorrhage in patients with the familial form was 6.8 years lower than that in those with the sporadic form, and middle cerebral artery aneurysms occurred more often in patients with familial disease. Sex distribution and number of aneurysms were similar in the two groups. Inheritance was compatible with autosomal dominant transmission in some families, and with autosomal recessive or multifactorial transmission in others. In our 5 families as well as in all 18 previously reported families with two affected generations, the age at the time of subarachnoid hemorrhage was invariably lower in later generations, which is suggestive of anticipation. We conclude that familial subarachnoid hemorrhage is a separate entity with occurrence at a young age, predilection for aneurysms of the middle cerebral artery, and variable modes of inheritance, including autosomal dominant inheritance with possible anticipation.

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Familial subarachnoid hemorrhage: Distinctive features and patterns of inheritance

Bromberg

Rinkel

Algra

et al. 1995

Annals of Neurology

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“…In the same series there was no suggestive history in 360 sibs surviving beyond infancy. Chakravorty and Gleadhill (1966) from this centre reviewed 337 cases of proven intracranial aneurysms and found six cases showing this familial incidence. Pratt (1967) did not consider that these figures *These cases were reported in an earlier publication (Chakravorty and Gleadhill, 1966 represented an increased risk to a relative, since the incidence of subarachnoid haemorrhage in the general population is as high as 6 to 16/100,000…”

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confidence: 99%

“…In a previous survey from this centre (Chakravorty and Gleadhill, 1966) six cases of familial cerebral aneurysms confirmed by arteriography were reported-a brother-sister pair and two mother-son pairs. These came from 337 cases during the period 1957 to 1965.…”

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confidence: 99%