The familial occurrence of berry aneurysm.

The familial incidence of intracranial aneurysms.

“…The finding ofthese congenital lesionsin more than one member of a family raises the questions concerning the role of genetic factors in their causation. Beumont (1968) suggested a pattern of simple dominant inheritance with subsequent events depending on variations in penetrance. Bilateral polycystic disease of the kidneys (adult form) is inherited as a dominant and is accompanied by the occurrence of intracranial aneurysms in 16% of gene carriers (Dalgaard, 1957).…”

“…Logue, Durward, Pratt, Piercy, and Nixon (1968), in a series of 90 patients with anterior cerebral artery aneurysms found two parents who had died of subarachnoid haemorrhage, but no necropsies had been done. Beumont (1968) reviewed cases from the English literature and added to these a family with three sisters affected, one with a parietal angioma and an internal carotid artery aneurysm, another with bilateral middle cerebral artery aneurysms, and the third with a posterior communicating aneurysm.…”

Familial intracranial aneurysm and infundibular widening

“…As an exercise we decided to exclude the two member per family reports as it is possible that a proportion of these occurred purely on the basis of chance. There are approximately 10 reports of familial aneurysm where 3 or more members are affected, 6 of these [3,4,14,[17][18][19] being reported in sufficient detail to allow further analysis. Our own family makes a seventh for such analysis.…”

Epidemiologie genetique des anevrismes intracraniens familiaux au Saguenay-Lac-St-Jean

“…Plusieurs auteurs présentent l'étude d'une seule famille en y exposant les cas (Ullrich et Sugar 1960;Graf 1966;Beumont 1968;Kak 1970;Brisman et Abbassioun 1971;Edelsohn et al 1972;Nagae et al 1972;Hashimoto 1977;Acosta-Rua 1978;Fox et Ko 1980;Fox 1982;Halal et al 1983;Berg et al 1987). Toutes ces études nous amènent à nous interroger de plus en plus sur les facteurs qui prédisposent ces individus à développer un anévrisme.…”