Familial influences on the full range of variability in attention and activity levels during adolescence: A longitudinal twin study

Peng, Chun-Zi; Grant, Julia D.; Heath, Andrew C.; Reiersen, Angela M.; Mulligan, Richard C.; Anokhin, Andrey P.

doi:10.1017/s0954579415001091

Cited by 7 publications

(12 citation statements)

References 54 publications

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“…The SWAN generates heritable trait scores that are widely and virtually normally distributed in the general population (Couvy-Duchesne et al, 2016;Crosbie et al, 2013;Greven et al, 2016;Hay et al, 2007;Peng et al, 2016;Polderman et al, 2007;Smit & Anokhin, 2017). To add support to the validity of the SWAN, we showed that high SWAN scores converge with a clinical diagnosis of ADHD consistent with the quantitative trait notion of psychopathology and SWAN (parent-and self-report) scores show convergent and divergent validity against other measures of ADHD, anxiety and OCD traits.…”

Section: Discussionmentioning

confidence: 65%

“…It is reliable, generates normally distributed scores in the general population, has high internal consistency, high test-retest reliability, converges reasonably with ADHD symptom measures and diverges from measures of emotionality (Arnett et al, 2013;Crosbie et al, 2013;Lai et al, 2013;Lakes, Swanson, & Riggs, 2012;Stroud et al, 2009;Swanson et al, 2012). Twin and sibling studies established the heritability (h 2 ) of the parent-and self-report SWAN (h 2 =0.24-0.94; Couvy-Duchesne et al, 2016;Crosbie et al, 2013;Greven et al, 2016;Hay, Bennett, Levy, Sergeant, & Swanson, 2007;Peng et al, 2016;Polderman et al, 2007;Smit & Anokhin, 2017). A GWAS using the SWAN identified suggestive genome-wide significant hits (n=1851; Ebejer et al, 2013).…”

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confidence: 99%

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Utility of the SWAN Scale for ADHD Trait-Based Genetic Research: A Validity and Polygenic Risk Study

Burton

Wright

Shan

et al. 2018

Preprint

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BackgroundValid and genetically-informative trait measures of psychopathology collected in the general population would provide a powerful complement to case/control genetic designs. We report the convergent, predictive and discriminant validity of the parent- and the self-report versions of the Strengths and Weaknesses of ADHD Symptoms and Normal Behavior Rating Scale (SWAN) for attention-deficit/hyperactivity disorder (ADHD) traits. We tested if SWAN ADHD scores were associated with ADHD diagnosis, ADHD polygenic risk, as well as with traits and polygenic risk for co-occurring disorders such as anxiety and obsessive-compulsive disorder (OCD).MethodsWe collected parent- and self-report SWAN scores in a community sample (n=15,560; 6-18 years of age) and created norms. Sensitivity-specificity analyses determined SWAN cut-points that discriminated those with a community ADHD diagnosis (n=972) from those without a community diagnosis. We validated cut-points from the community sample in a clinical sample (266 ADHD cases; 36 controls). We tested if SWAN scores were associated with anxiety and obsessive-compulsive (OC) traits and polygenic risk for ADHD, OCD and anxiety disorders.ResultsBoth the parent- and the self-report SWAN measures showed high convergent validity with established ADHD measures and distinguished ADHD participants with high sensitivity and specificity in the community sample. Cut-points established in the community sample discriminated ADHD clinic cases from controls with a sensitivity of 86% and specificity of 94%. High parent- and self-report SWAN scores and scores above the community-based cut-points were associated with polygenic risk for ADHD. High ADHD traits were associated with high anxiety traits, but not OC traits. SWAN scores were not associated with OCD or anxiety disorder polygenic risk.ConclusionThe parent- and self-report SWAN are potentially useful in genetic research because they predict ADHD diagnoses and are associated with ADHD polygenic risk.

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Section: Discussionmentioning

confidence: 65%

mentioning

confidence: 99%

Utility of the SWAN Scale for ADHD Trait-Based Genetic Research: A Validity and Polygenic Risk Study

Burton

Wright

Shan

et al. 2018

Preprint

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“…The current study adds to the previous literature to support the SWAN as a valid tool for use in quantitative genetic research. The SWAN generates heritable trait scores that are widely and virtually normally distributed in the general population (Couvy‐Duchesne et al., ; Crosbie et al., ; Greven et al., ; Hay et al., ; Peng et al., ; Polderman et al., ; Smit & Anokhin, ). In this study, we showed that high SWAN scores converged with a diagnosis of ADHD in both Spit for Science and clinical samples consistent with the notion that ADHD is the extreme of a quantitative trait.…”

Section: Discussionmentioning

confidence: 99%

“…It is reliable, generates normally distributed scores in the general population, has high internal consistency, high test‐retest reliability, converges reasonably with ADHD symptom measures and diverges from measures of emotionality (Arnett et al., ; Crosbie et al., ; Lai et al., ; Lakes, Swanson, & Riggs, ; Stroud et al., ; Swanson et al., ). The parent‐ and self‐report SWAN are heritable ( h 2 = 0.24–0.94; Couvy‐Duchesne et al., ; Crosbie et al., ; Greven et al., ; Hay, Bennett, Levy, Sergeant, & Swanson, ; Peng et al., ; Polderman et al., ; Smit & Anokhin, ). An underpowered GWAS ( n = 1,851) using the SWAN identified suggestive genome‐wide significant hits (Ebejer et al., ).…”

Section: Introductionmentioning

confidence: 99%

SWAN scale for ADHD trait‐based genetic research: a validity and polygenic risk study

Burton

Wright

Shan

et al. 2019

Child Psychology Psychiatry

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Background Population‐based samples with valid, quantitative and genetically informative trait measures of psychopathology could be a powerful complement to case/control genetic designs. We report the convergent and predictive validity of the parent‐ and self‐report versions of the Strengths and Weaknesses of ADHD Symptoms and Normal Behavior Rating Scale (SWAN). We tested if SWAN scores were associated with ADHD diagnosis, ADHD polygenic risk, as well as traits and polygenic risk for disorders that co‐occur with ADHD: anxiety and obsessive‐compulsive disorder (OCD). Methods We collected parent‐ and self‐report SWAN scores in a sample of 15,560 children and adolescents (6–17 years) recruited at a science museum (Spit for Science sample). We established age and sex norms for the SWAN. Sensitivity‐specificity analyses determined SWAN cut‐points that discriminated those with and without a reported ADHD diagnosis. These cut‐points were validated in a clinic sample (266 ADHD cases; 36 controls). Convergent validity was established using the Conners’ parent‐ and self‐report scales. Using Spit for Science participants with genome‐wide data (n = 5,154), we tested if low, medium and high SWAN scores were associated with polygenic risk for ADHD, OCD and anxiety disorders. Results Parent‐ and self‐report SWAN scores showed high convergent validity with Conners’ scales and distinguished ADHD participants with high sensitivity and specificity in the Spit for Science sample. In a clinic sample, the Spit for Science cut‐points discriminated ADHD cases from controls with a sensitivity of 84% and specificity of 92%. High SWAN scores and scores above the Spit for Science cut‐points were significantly associated with polygenic risk for ADHD. SWAN scores were not associated with polygenic risk for OCD or anxiety disorders. Conclusions Our study supports the validity of the parent‐ and self‐report SWAN scales and their potential in ADHD population‐based genetic research.

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“…As expected, it was biologically valuable to hypothesize an association between the Val158Met polymorphisms of COMT gene and clinical phenotypes in ADHD children[7][8][9]. According to this hypothesis, G (valine) variant of COMT gene was associated with the faster depletion of catecholaminergic neurotransmitters from synapses in the prefrontal cortex[10][11][12][13].Recent studies have suggested that the Val158Met polymorphisms of COMT gene might be involved in the pathogenesis of ADHD children. Eisenberg et al found that G/A variations of COMT gene had a significant relation with ADHD children.…”

mentioning

confidence: 88%

Pathogenic study on catechol-O-methyltransferase gene and catecholaminergic neurotransmitters with attention deficit hyperactivity disorder in Chinese children

Xiong¹,

Yan²,

Shi

2020

Preprint

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Background: This study analyzed a correlation between the Val158Met polymorphisms of catechol-O-methyltransferase (COMT) gene and catecholaminergic neurotransmitters in ADHD children. Methods: All subjects were genotyped for the Val158Met polymorphisms of COMT gene and determined in the difference of dopamine and noradrenalin by a 1:1 paired case-control study. Results: The frequencies of A/A, G/A and G/G were 51.67%, 41.11% and 7.22% in the case group, 62.22%, 31.11% and 6.67% in the control group. There was a significant difference in the distribution of all genotypes of COMT gene between the two groups (OR=1.85, χ2=7.80, P<0.05). The serum concentrations of dopamine and noradrenalin were 1.42±0.34 ng/ml and 177.70±37.92 pg/ml in the case group, 1.94±0.42 ng/ml and 206.20±42.45 pg/ml in the control group. There were the significant differences in the levels of dopamine and noradrenalin between the two groups (dopamine: t=4.30, P<0.01. noradrenalin: t=2.24, P<0.05). Conclusions: Our study suggested that there was the positive association between the Val158Met polymorphisms of COMT gene and catecholaminergic neurotransmitters in ADHD children.

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Familial influences on the full range of variability in attention and activity levels during adolescence: A longitudinal twin study

Cited by 7 publications

References 54 publications

Utility of the SWAN Scale for ADHD Trait-Based Genetic Research: A Validity and Polygenic Risk Study

Utility of the SWAN Scale for ADHD Trait-Based Genetic Research: A Validity and Polygenic Risk Study

SWAN scale for ADHD trait‐based genetic research: a validity and polygenic risk study

Pathogenic study on catechol-O-methyltransferase gene and catecholaminergic neurotransmitters with attention deficit hyperactivity disorder in Chinese children

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