Familial Neonatal Transient Hypothyroidism Due to Maternal TSH-Binding Inhibitor Immunoglobulins

The Prediction of thyroid Function in Infants Born to Mothers with Chronic Thyroiditis.

“…When the TSH-receptor stimulating antibodies cross the placenta they can cause neonatal thyrotoxicosis (Munro, et al, 1978, Matsuura, et al, 1988, Tamaki, et al, 1988a while TSH-receptor blocking antibodies can cause neonatal transient hypothyroidism (Matsuura, et al, 1980). However, the relation between the titer of mother's TSH-receptor antibody and the status of the offspring has not been fully elucidated.…”

Clinical Applications of TSH Receptor Antibodies in Thyroid Diseases

“…These blocking antibodies (TSBAbs) compete with TSH for receptor binding and block the biological effects of TSH on thyroid cells, including cAMP production, iodine uptake, and thyroid cell growth (26)(27)(28). They induce transient neonatal hypothyroidism when transferred across the placenta (29,30). TSBAb assay quantitates inhibition by autoantibodies of the increase in cAMP production or the iodide uptake in response to a standard concentration of TSH in the FRTL-5 cell (26)(27)(28) or CHO-TSHR cell (31,32).…”

Review Article on Congenital Hypothyroidism and Newborn Screening Program in Africa; the Present Situation and the Way Forward

“…Mother with grave's disease may have transplacental passage of medications (methimazole, propylthiouracil), TSH blocking antibodies [18,19] and maternal iodine deficiency may contribute to this form of CH. It is often difficult to distinguish newborns with transient CH from those with permanent CH, maternal TSH antibodies may be in the newborn's circulation for several weeks to months [20].…”