Familial osteochondritis dissecans: A dysplasia of articular cartilage?

Kozlowski, K.; Middleton, R. W. D.

doi:10.1007/bf00350575

Cited by 31 publications

(14 citation statements)

References 12 publications

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“…Many authors have suggested a familial inheritance, even to the point of describing it as a mild form of skeletal dysplasia with associated short stature [43,58,59,68,82]. An autosomal-dominant inheritance pattern is espoused by at least two separate authors [58,68].…”

Section: Etiologymentioning

confidence: 99%

A Review of Knowledge in Osteochondritis Dissecans: 123 Years of Minimal Evolution from König to the ROCK Study Group

Edmonds

Polousky

2013

Clinical Orthopaedics &Amp; Related Research

215

223

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Background Osteochondritis dissecans (OCD) was first described to provide an explanation for the nontraumatic development of loose bodies within a joint. Despite many reports on the subject, there remains no clear understanding of the etiology, natural history, or treatment. Questions/purposes This review was undertaken to delineate (1) the etiology of OCD; (2) the presentation and locations; (3) the most appropriate imaging modalities; and (4) the most effective treatment strategies. Methods We reviewed the English literature using a database compiled from a Medline search for ''osteochondritis dissecans''. We identified 1716 publications, 1246 of which were in English. After exclusions, we reviewed 748 articles and of these cited 85. The observations of each study were then synthesized into this report. Results There appears to be no consensus concerning the etiology of OCD lesions. The presentations and locations are variable, but the knee, ankle, and elbow are most commonly involved. Although plain film assessment is important in OCD, there appears to be a trend toward the use of MRI, but the preferred sequences are in evolution. We found no consensus on the treatment of these lesions, related in part to the lack of agreement of methods for assessing outcomes. Conclusions Despite more than a century of study, we have made little advancement in our understanding of OCD. A study group has been formed to address this issue and actively seeks to answer these unknown issues regarding OCD.

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Section: Etiologymentioning

confidence: 99%

A Review of Knowledge in Osteochondritis Dissecans: 123 Years of Minimal Evolution from König to the ROCK Study Group

Edmonds

Polousky

2013

Clinical Orthopaedics &Amp; Related Research

215

223

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“…Osteochondritis dissecans (OCD), osteochondritis deformans (Perthes disease) and tibial tubercle avulsion fracture were described as part of the symptom complex in some heritable bone disorders [ 15 - 20 ]. Familial type of osteochondritis dissecans has been reported in the literature and autosomal dominant pattern of inheritance was suggested [ 21 , 22 ]. To the best of our knowledge this is the first clinical report describe the simultaneous occurrence of osteochondritis dissecans and Osgood Schlatter syndrome in connection with Stickler syndrome in two family subjects.…”

Section: Introductionmentioning

confidence: 99%

Osteochondritis dissecans and Osgood Schlatter disease in a family with Stickler syndrome

2009

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We observed that the nature of the articular and physeal abnormalities was consistent with a localised manifestation of a more generalised epiphyseal dysplasia affecting the weight-bearing joints. In these two patients, OCD and OSS appeared to be the predominant pathologic musculoskeletal consequences of an underlying Stickler's syndrome. It is empirical to consider generalised epiphyseal dysplasia as a major underlying causation that might drastically affect the weight-bearing joints.

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“…Identical twin studies have shown male pairs who developed OCD of the MFC, one set with matching lesions in the left knee [10] and the other set with bilateral lesions [11], indicating a strong genetic component. Previous studies have also shown what appears to be a genetic Three OCD Lesions in One Knee 1189 linkage with a Mendelian inheritance pattern [8,12,14].…”

Section: Discussionmentioning

confidence: 86%