Familial recurring cardiac myxoma

Abstract

Summary:A 34-year-old woman presented with her fourth occurrence of an atrial myxoma and a right lower lung field mass. Her surgical history was extensive. In addition to resection of three previous atrial myxomas, she had undergone resection of her adrenal glands as a teenager because of Cushing's syndrome, and a hysterectomy at age 26 revealed a myxoid leiomyoma. Family history was remarkable as a maternal uncle and daughter died from embolic complications of left atrial myxomas and her sister previously had a left atrial myxoma resected. The patient underwent uncomplicated removal of the myxoma, and resection of the lung mass revealed a granuloma. A review of typical and atypical aspects of cardiac myxomas is provided including a rare and recently described syndrome of familial cardiac myxoma associated with Cushing's syndrome, spotty skin pigmentation and other myxoid tumors.

Surgical treatment of atrial myxomas, 6 years’ experience via standard sternotomy

“…There is a report of 3×2cm right atrial myxoma developing at the site of trans-septal catheterization for balloon mitral valvuloplasty. Such masses were described as reactive myxomas and not true neoplasms [5] . Two-dimensional echocardiography is the diagnostic procedure of choice.…”

“…Seven percent are inherited (familial myxomas), that may grow in any of the four cardiac chambers [4,5] . The diameters of masses in current study ranged between 3 and 7 cm.…”

“…The diameters of masses in current study ranged between 3 and 7 cm. Reported dimensions in literature ranged between 0.5 and 13 cm [5] . Intra atrial mass can be an organized thrombus after closure of a congenital atrial septal defect [6] or developing at the site of trans-septal catheterization.…”