Familiäre Tumorerkrankungen im Knochen

Jundt, Gernot; Baumhoer, Daniel

doi:10.1007/s00292-010-1364-4

Cited by 4 publications

(1 citation statement)

References 25 publications

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“… 8 Thus, regular monitoring and, if malignant tumor growth is diagnosed, surgical treatment of patients suffering from HME is necessary. 8 , 9 Against the background of hypothesis that severely affected patients with HME are associated with palpable shoulder exostoses, we report for the first time a coincidentally found bilateral formation of osteochondromas in the scapulothoracic spaces in a patient suffering from HME. 10 Hitherto, no case of bilateral osteochondromas arising from the scapula forming a scapulothoracic neojoint is described in the literature.…”

Section: Introductionmentioning

confidence: 99%

Bilateral scapulothoracic osteochondromas in a patient with hereditary multiple exostosis: a case report and review of the literature

2016

Orthop Rev

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Hereditary multiple exostosis (HME) is an autosomal dominant disorder characterized by two or more benign growing, cartilage capped tumors of long bones called osteochondromas. If abnormal growth and clinical symptoms of osteochondromas newly appear in adults, malignant transformation of the usually benign growing tumors should be suspected and diagnostic testing should be initiated. Against the background of hypothesized higher malignant transformation of osteochondromas into chondrosarcoma in individuals with shoulder exostoses, we report a case of bilateral scapulothoracic osteochondromas in a patient suffering from HME. A 60-year-old female with HME complained of chest pain while being hospitalized for bilateral femoral fractures. A computed tomography scan of the chest was performed to rule out pulmonary embolism. However, bilateral osteochondromas in the scapulothoracic spaces were detected. Due to absence of radiographic evidences for malignant transformation in the patient, invasive diagnostic procedures such as biopsy and histological examination were recommended in order to exclude malignant transformation of both osteochondromas. Physicians should be aware that patients with HME who present with shoulder pain should be examined for osteochondromas in the scapulothoracic space. Due to possible sarcomatous transformation, regular follow-ups are necessary for adolescents and adults.

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Section: Introductionmentioning

confidence: 99%

Bilateral scapulothoracic osteochondromas in a patient with hereditary multiple exostosis: a case report and review of the literature

2016

Orthop Rev

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Osteochondrom und multiple Osteochondrome

et al. 2013

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The risk of malignant transformation of SO is generally low. Axial lesions as well as recurrent osteochondromas and MO seem to have an increased risk of malignant transformation. The follow-up, requiring sufficient primary diagnostics, includes regular self-control and can usually be clinically carried out in more peripherally located lesions but in certain cases supplementary X-ray imaging is needed. In cases of anatomical regions which are more difficult to access manually, follow-up examination by magnetic resonance imaging (MRI) is the method of choice. Especially MO patients seem to benefit from long-term follow-up: when the tumor is located in the trunk and in (proximal) long bones MRI or whole-body MRI, respectively, should be performed once a year after skeletal maturity because of the higher risk of malignant transformation in these patients.

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Die klonale Evolution des Osteosarkoms

Baumhoer

2016

Pathologe

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Familiäre Tumorerkrankungen im Knochen

Cited by 4 publications

References 25 publications

Bilateral scapulothoracic osteochondromas in a patient with hereditary multiple exostosis: a case report and review of the literature

Bilateral scapulothoracic osteochondromas in a patient with hereditary multiple exostosis: a case report and review of the literature

Osteochondrom und multiple Osteochondrome

Die klonale Evolution des Osteosarkoms

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