Family history of cancer and subsequent risk of cancer: A large‐scale population‐based prospective study in Japan

Abstract

Family history (FH) of cancer is an important factor of increased risk of several cancers. Although the association between FH of cancer and concordant cancer risk has been reported in many previous epidemiological studies, no comprehensive prospective study with adjustment for lifestyle habits has evaluated the association of FH of cancer and concordant cancer risk. We investigated the association between FH of cancer and concordant cancer risk in a Japanese population-based prospective study, initiated in 1990 for cohort I and in 1993 for cohort II. We analyzed data on 103,707 eligible subjects without a history of cancer who responded to a self-administered questionnaire including FH of cancer at baseline. Study subjects were followed through 2012 and analyzed using multivariable-adjusted Cox proportional hazards regression models. During 1,802,581 person-years of follow-up, a total of 16,336 newly diagnosed cancers were identified. Any site (Hazard ratios = 1.11 (95% confidence interval = 1.07-1.15]), esophagus (2.93 [1.06-3.51]) and bladder cancers (6.06 [2.49-14.74]) with FH of the concordant cancer were associated with an increased risk compared to those without FH. Our findings suggest that having FH of cancer is associated with an increased risk of several concordant cancer incidences in an Asian population. Enquiring about FH of several types of cancer may be important in identifying groups at high-risk of those cancers.

The relationship between malignancy and Behçet's disease features

“…Malignancy development is associated with non-modifiable risk factors such as family history and gender, and modifiable risk factors such as smoking, alcohol, physical inactivity, and obesity. Knowing a person's family history can help determine the risk of hereditary diseases, such as cancer, where 5% to 10% of cases are inherited (18,26). In our study, all malignant and premalignant lesions were solid organ related and were present in female patients.…”

Serum levels of retinol-binding protein 4 and the risk of non-small cell lung cancer

“…[ 16 – 18 ] This study shows that family history and smoking history of NSCLC can increase the incidence of NSCLC, which is consistent with many studies. [ 19 ] And the serum lipids TC, TG, LDL, RBP4 in NSCLC patients are higher than those in normal people, and HDL is lower than that of normal people. It shows that hyperlipidemia is related to the incidence of NSCLC.…”

Prevalence of family history of cancer in the NC-CCAPH consortium of Japan

“…However, the recommendations do not specify physician assessment of family history. Family history is not always assessed and assessment methods are inconsistent though the rationale for obtaining this history is well established 4 . Several epidemiological studies exist on family history of cancer and various cancer outcomes in Japan 4 .…”

“…Family history is not always assessed and assessment methods are inconsistent though the rationale for obtaining this history is well established 4 . Several epidemiological studies exist on family history of cancer and various cancer outcomes in Japan 4 . However, a broad overview and update on the current prevalence of family history of total and site-specific cancer stratified by sex for age and birth cohorts are lacking.…”

“…Multiple FDR with a history of cancer affects an individual's cancer risk 1,3 . While the complex interaction of genetic and environmental exposures contributing to the association between family history of cancer and cancer risk have been extensively studied [4][5][6] , exact pathways remain inconclusive 7 .…”