Family history of hematopoietic malignancies and risk of non-Hodgkin lymphoma (NHL): a pooled analysis of 10 211 cases and 11 905 controls from the International Lymphoma Epidemiology Consortium (InterLymph)

Abstract

A role for genetic susceptibility in nonHodgkin lymphoma (NHL) is supported by the accumulating evidence of common genetic variations altering NHL risk. However, the pattern of NHL heritability remains poorly understood. We conducted a pooled analysis of 10 211 NHL cases and 11 905 controls from the International Lymphoma Epidemiology Consortium (InterLymph) to evaluate NHL risk among those with hematopoietic malignancies in first-degree relatives. Odds ratios (ORs) and 95% confidence intervals (CIs) of NHL and its subtypes were estimated from unconditional logistic regression models with adjustment for confounders. NHL risk was elevated for individuals who reported first-degree relatives with NHL (OR ‫؍‬ 1.5; 95% CI ‫؍‬ 1.2-1.9), Hodgkin lymphoma (OR ‫؍‬ 1.6; 95% CI ‫؍‬ 1.1-2.3), and leukemia (OR ‫؍‬ 1.4; 95% CI ‫؍‬ 1.2-2.7). Risk was highest among individuals who reported a brother with NHL (OR ‫؍‬ 2.8; 95% CI ‫؍‬ 1.6-4.8) and was consistent for all NHL subtypes evaluated. If a first-degree relative had Hodgkin lymphoma, NHL risk was highest if the relative was a parent (OR ‫؍‬ 1.7; 95% CI ‫؍‬ 1.0-2.9). If a first-degree relative had leukemia, NHL risk was highest among women who reported a sister with leukemia (OR ‫؍‬ 3.0; 95% CI ‫؍‬ 1.6-5.6). The pattern of NHL heritability appeared to be uniform across NHL subtypes, but risk patterns differed by specific hematopoietic malignancies and the sex of the relative, revealing critical clues to disease etiology. (Blood.

Medical History, Lifestyle, Family History, and Occupational Risk Factors for Peripheral T-Cell Lymphomas: The InterLymph Non-Hodgkin Lymphoma Subtypes Project

“…Prior to these analyses, the only established risk factors for T-cell lymphomas were family history of hematologic malignancies (27) and history of celiac disease (28). In particular, there has been a longstanding association between celiac disease and enteropathy-type PTCL (29) which may arise as a result of clonal proliferation of phenotypically abnormal intraepithelial lymphocytes associated with the loss of CD8 expression and increased interleukin-15 expression (30,31).…”

Non‐Hodgkin lymphoma and obesity: A pooled analysis from the InterLymph Consortium

“…[40][41][42][43][44] Firstly, individual data were combined in an unconditional logistic regression model adjusting for study, age, sex and race. To test for between-study heterogeneity, this model was compared using the likelihood ratio test with the model that included an additional term for interaction between the anthropometric variable and a variable indexing the studies.…”

Allogeneic hematopoietic stem cell donation—standardized assessment of donor outcome data: A consensus statement from the Worldwide Network for Blood and Marrow Transplantation (WBMT)

“…Epidemiological studies in families of patients with hematological neoplasms suggest that the risk to develop any malignancy is at least twice that of a normal population. 38 Some of these donor characteristics may also apply to unrelated donors. So far it is not known how many volunteers joined the unrelated donor registries because of close relationships with a patient (that is, being a relative or having had close contact during many years, which could also include a common exposure to carcinogenic agents) and it is obvious that motivation patterns might differ between different countries depending on different recruitment strategies of individual registries.…”