Family History of Psychiatric Illness as a Risk Factor for Schizoaffective Disorder

Laursen, Thomas Munk; Labouriau, Rodrigo; Licht, Rasmus W; Bertelsen, Aksel; Munk‐Olsen, Trine; Mortensen, Preben Bo

doi:10.1001/archpsyc.62.8.841

Cited by 116 publications

(93 citation statements)

References 23 publications

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“…The risk magnitudes in offspring were in line with earlier publications on familial psychotic disorders and schizophrenia (Albus and Maier, 1995;Cannon et al, 1998;Cardno et al, 1999;Kendler and MacLean, 1990;Laursen et al, 2005;Shih et al, 2004). The present study adds further knowledge to previous research because of its approach; it was based on all hospitalized cases in Sweden between 1987 and 2004, which yielded 21,199 male and 19,029 female cases of psychotic disorders in addition to 12,799 paternal and 23,021 maternal cases of psychotic disorders (including schizophrenia).…”

Section: Discussionsupporting

confidence: 86%

“…These findings have not been reported consistently (Maier et al, 1993;Sham et al, 1994). The influence of genetic factors has been reported to have a significantly higher effect in women than men in some studies (Maier et al, 1993) but not in others (Albus and Maier, 1995;Cannon et al, 1998;Laursen et al, 2005). Consequently, there is a need for further research into the genetic etiology of psychotic disorders and schizophrenia with specific attention paid to age and sex effects.…”

Section: Introductionmentioning

confidence: 91%

“…Although the exact etiology of the disorder is not understood, family, twin and adoption studies have suggested that genetic factors play a major role in the transmission of psychotic disorders. In a Danish cohort study, a 3.22-fold risk of psychotic disorders was observed among first-degree relatives (Laursen et al, 2005). From twin studies, the heritability of psychotic disorders was estimated to be over 80% (Cannon et al, 1998;Cardno et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

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Age-specific familial risks of psychotic disorders and schizophrenia: A nation-wide epidemiological study from Sweden

Sundquist

2007

Schizophrenia Research

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Objective-This study analyzed men and women separately by age at hospital diagnosis of psychotic disorder or schizophrenia and by maternal or paternal disease after taking several possible confounders into account. Methods-The MultigenerationRegister, in which all men and women born in Sweden from 1932 onwards are registered together with their parents, was linked to hospital data. This yielded 21,199 male and 19,029 female cases of psychotic disorders in addition to 12,799 paternal and 23,021 maternal cases of psychotic disorders (including schizophrenia). Standardized incidence ratios (SIRs) were calculated as the ratio of observed and expected number of cases among men and women with mothers and/or fathers affected by psychotic disorders or schizophrenia, compared with men and women whose mothers and/or fathers were not affected by psychotic disorders or schizophrenia.Results-The overall significant SIRs among men and women with a mother, father or both parents hospitalized for psychotic disorder varied between 2.86 and 20.30. Maternal transmission of psychotic disorder was stronger than paternal, and the highest SIRs were found in the youngest age groups. Similar results were found when the subgroup schizophrenia was analyzed separately. Maternal or paternal schizophrenia implied higher risks for the offspring than maternal or paternal psychotic disorders.Conclusions-Hereditary factors have a strong influence on the onset of psychotic disorders and schizophrenia. Young people and individuals with both parents affected by these diseases need special attention as their SIRs were particularly increased.

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Section: Discussionsupporting

confidence: 86%

Section: Introductionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

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Age-specific familial risks of psychotic disorders and schizophrenia: A nation-wide epidemiological study from Sweden

Sundquist

2007

Schizophrenia Research

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“…They are clearly incompatible with the argument that schizoaffective disorder is a variant of bipolar disorder 5, 48, 49. Nor are they easy to reconcile with the longstanding—and currently highly topical—proposal that schizoaffective disorder represents the midpoint along a continuum of psychosis, as conceptualized either genetically 6, 13, clinically 8, 50, 51, or both 52. This would predict less volume change in schizoaffective disorder than in schizophrenia, something that none of the analyses carried out in this study supported.…”

Section: Discussionmentioning

confidence: 96%

“…Clinical studies have performed little to clarify the status of the disorder, finding that it does not clearly separate from schizophrenia or bipolar disorder, either cross‐sectionally 8, 9, or in terms of its course and outcome (for a review, see 10). Similarly, family history studies have found high rates of affective disorders in the first‐degree relatives of patients with schizoaffective disorder, but also elevated rates of schizophrenia 11, 12, 13, 14.…”

Section: Introductionmentioning

confidence: 91%

Brain structural changes in schizoaffective disorder compared to schizophrenia and bipolar disorder

Amann

Canales‐Rodríguez

Madre

et al. 2015

Acta Psychiatr Scand

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ObjectiveBrain structural changes in schizoaffective disorder, and how far they resemble those seen in schizophrenia and bipolar disorder, have only been studied to a limited extent.MethodForty‐five patients meeting DSM‐IV and RDC criteria for schizoaffective disorder, groups of patients with 45 matched schizophrenia and bipolar disorder, and 45 matched healthy controls were examined using voxel‐based morphometry (VBM).ResultsAnalyses comparing each patient group with the healthy control subjects found that the patients with schizoaffective disorder and the patients with schizophrenia showed widespread and overlapping areas of significant volume reduction, but the patients with bipolar disorder did not. A subsequent analysis compared the combined group of patients with the controls followed by extraction of clusters. In regions where the patients differed significantly from the controls, no significant differences in mean volume between patients with schizoaffective disorder and patients with schizophrenia in any of five regions of volume reduction were found, but mean volumes in the patients with bipolar disorder were significantly smaller in three of five.ConclusionThe findings provide evidence that, in terms of structural gray matter brain abnormality, schizoaffective disorder resembles schizophrenia more than bipolar disorder.

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Severe Mental Disorders in Offspring With 2 Psychiatrically Ill Parents

Gottesman

Laursen

Bertelsen

et al. 2010

Arch Gen Psychiatry

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219

155

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Family History of Psychiatric Illness as a Risk Factor for Schizoaffective Disorder

Abstract: Schizoaffective disorder is not simply a subgroup of either bipolar disorder or schizophrenia but may be genetically linked to both, with schizoaffective disorder being a subtype of each or a genetic intermediate form.

Cited by 116 publications

References 23 publications

Age-specific familial risks of psychotic disorders and schizophrenia: A nation-wide epidemiological study from Sweden

Age-specific familial risks of psychotic disorders and schizophrenia: A nation-wide epidemiological study from Sweden

Brain structural changes in schizoaffective disorder compared to schizophrenia and bipolar disorder

Severe Mental Disorders in Offspring With 2 Psychiatrically Ill Parents

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