Family studies of immunoglobulin levels in Iraq

Abstract

The extent of the contribution of genetic and environmental factors to the variation in levels of serum immunoglobulin G, A, M and E was studied among families of Arabs and Kurds of Iraq. Heritability (h2) values were calculated from offspring-parent, offspring-mid-parent and sib-sib comparisons and were all positive and moderate. All values were significant for all four immunoglobulins, being generally lower in Arabs than in Kurds. The h2 estimate based on offspring-parent and offspring-mid-parent were generally lower than those based on sib-sib comparisons, suggesting that these values were inflated by the common environment of full sibs. Genetic correlations between IgG--IgE and IgG--IgA were relatively high, reflecting a common regulation in the level of these immunoglobulins. IgM showed low genetic correlation with other immunoglobulins. All environment correlations were positive, and rather higher in the Kurds than the Arabs, indicating that environmental factors influence the level of all four classes of immunoglobulins.

Genetic polymorphism of serum proteins and levels of immunoglobulin and complement components in high caste community (Brahmins) of Madhya Pradesh, India

“…The mean IgG level at 1,405_+.271 mg~ falls in the range of means reported for other Indian populations (1,200-1,675 mg~, Sehgal et al, 1970, Samuel etal., 1970Gupta et aI., 1972;Gupta etal., 1975)but appears slightly elevated over those in south west Asis, in populations of Afghanistan and Iraq (Agarwal et aL, 1970;A1-Agidi et al, 1977) and in western Europe (Hitzig, 1957;Stiehm and Fudenberg, 1966;Hobbs, 1972). The Brahmin mean level shows some similarity to samples from Tanzania, New Guinea and Venezuela (Bennett et al, 1970;Roberts et al, 1979;Crane et al, 1971;Wells, 1968;' Arends and Gallango, 1966).…”

Cord Serum AFP and the Immunological Status of the Mother: a Lack of Correlation

“…IgG was measured by radial immunodiffusion using Behringwerke Tripartigen plates, by the technique standard in this department (1). Data on the obstetric status of the patients were taken from the clinical records after all the samples had been analysed.…”

Immunoglobulins, Immunoglobulin G Subclasses and Complement in Adult Omanis

“…There is no published information on the normal values of these "immunoproteins" in healthy adult Omanis and very little data on the Gulf Arabs in general. [1][2][3][4][5] Reports from elsewhere would indicate that there may be significant differences depending on race and environment. 6,7 We have studied 100 healthy adult Omanis (50 males/50 females) in order to obtain local reference values to be used when evaluating patients.…”