The risk of famine is rising in many countries today. Bold changes to famine information and response systems are urgently needed to improve capacities to prevent famine. To this end, the paper identifies six insights from social‐ecological systems (SES) thinking for understanding and preventing famine. It argues that a state of famine emerges from human–environment interdependencies, complex causality, and non‐linear system dynamics, shaped by history and context. The likelihood of famine can be reduced by strengthening resilience to the diverse stresses and shocks that drive destitution, food insecurity, undernutrition, morbidity, and mortality. SES thinking offers new opportunities to understand the dynamics of famine, diagnose lesser‐known drivers, pinpoint new metrics, ascertain leverage points for intervention, and develop conceptual frameworks to inform policy. SES concepts and methods could also support the development of practical analytical tools to guide decisionmakers on how, where, and when to intervene most effectively and efficiently to strengthen resilience to the drivers of famine.