Famotidine versus omeprazole, in combination with amoxycillin and tinidazole, for eradication of Helicobacter pylori infection

Abstract

Two-week courses of either high-dose famotidine or omeprazole, both combined with amoxycillin and tinidazole, are equally effective for eradication of H. pylori infection. In a 2-week triple therapy, metronidazole resistance has no significant impact on eradication rates.

Meta‐analysis: the effect of antibiotic resistance status on the efficacy of triple and quadruple first‐line therapies for Helicobacter pylori

“… ANB, 27–32 0, NTB, 27, 33–45 ANG, 33, 40 38, 41, 46–66 CNG, 22, 31, 53, 54, 57, 60–64, 67–90 ACG, 38, 59, 62, 63, 67, 70, 78, 84, 87, 91–105 MTBG, 34, 38, 39, 58, 99, 106–116 ACMG 82, 117 and CMBR 31, 67, 111, 113, 118 …”

“…Amoxicillin, nitroimidazole and a gastric acid inhibitor Amoxicillin, a nitroimidazole and a gastric acid inhibitor (ANG) were used to treat 1945 subjects in North America (one study, two arms), Asia (seven studies, 17 arms), Australia (one study, two arms) and Europe (15 studies, 36 arms) 33, 40, 41, 46–66 . Most treatment arms used metronidazole (88%) as the nitroimidazole, and omeprazole (67%) as the gastric acid inhibitor; 18% used lansoprazole and 11% used famotidine.…”

“…References are reported in the order they are presented in the figure. ANG 33, 40, 41, 47, 47–51, 51–55, 55, 56, 56–61, 61–66 and ACG 38, 62, 67, 70, 70, 91, 91–96, 96, 97, 97, 99, 100, 100–102, 102, 102–104, 104, 104, 105 …”

Lafutidine, a Novel Histamine H2‐Receptor Antagonist, vs. Lansoprazole in Combination with Amoxicillin and Clarithromycin for Eradication of Helicobacter pylori

“…A recent randomized, controlled trial showed that famotidine and omeprazole, combined with clarithromycin and metronidazole, were equivalent for cure of H. pylori infection [10]. In contrast, other data showed that ranitidine, when used together with amoxicillin and metronidazole, was less effective than omeprazole [12]. In our series, the 1‐week course of LFT plus amoxicillin and clarithromycin yielded acceptably high eradication rates of 85.2 and 88.2% on intention‐to‐treat and per protocol analyses, respectively, which were comparable with those of the LPZ‐based regimen with similar combination of antibiotics.…”

Meta‐analysis: proton pump inhibitors vs. H2‐receptor antagonists — their efficacy with antibiotics in Helicobacter pylori eradication

“…Finally, one more study was excluded because it evaluated these therapies as second‐line treatment for previous eradication failures 15 . Therefore, 20 studies finally fulfilled the inclusion criteria and contained data for the planned comparison; 16–35 detailed characteristics of these studies are shown in Table 1.…”