Fanconi Anemia: main oral manifestations

D'Agulham, Anna Clara Duszczak; Chaiben, Cassiano Lima; Lima, Antônio Adílson Soares de; Torres‐Pereira, Cassius Carvalho; Machado, Maria Ângela Naval

doi:10.1590/1981-8637201400030000082275

Cited by 8 publications

(5 citation statements)

References 33 publications

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“…5 Another reason is that leukocyte deficiency, reducing the immunity of these individuals, leads to the development of ulcerated lesions. 21 Traumatic nonulcerated lesions and petechiae are common in these individuals and are normally related to low platelet counts.…”

Section: Discussionmentioning

confidence: 99%

Dental Perspective of Rare Disease of Fanconi Anemia: Case Report with Review

Goswami

Bhushan

Goswami³

2016

Clin Med Insights Case Rep

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Fanconi anemia is an extremely rare genetic disease characterized by chromosomal instability that induces congenital alterations in individuals. It causes defective hemopoiesis ultimately leading to bone marrow failure. Patients are susceptible to recurrent infections and increased risk of hemorrhage, as well as delayed and poor wound healing. Herein, we report a case of Fanconi anemia in which various classical signs of the disease were present. The patient has been on regular follow-up since three and a half years for management of dental problems. The different aspects of this rare disorder are discussed with emphasis on oral manifestations and their influence on the general health of affected patients. Due to an increased susceptibility to developing cancers in this specific population, it is imperative for pediatric dentists to know about the common oral manifestations and potentially cancerous lesions, in order to make an early diagnosis and provide comprehensive care and maintenance of oral health in affected individuals.

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Section: Discussionmentioning

confidence: 99%

Dental Perspective of Rare Disease of Fanconi Anemia: Case Report with Review

Goswami

Bhushan

Goswami³

2016

Clin Med Insights Case Rep

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“…Factors such as regular sugar consumption and specific cariogenic bacteria may lead to the development of dental caries. Low economic status and limited access to oral health care could also play a role [51].…”

Section: Fanconi Anaemiamentioning

confidence: 99%

Exploring the Impact of Blood Disorders on Dental Caries

Kale,

Nelakurthi,

Paul

2023

Cureus

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Blood comprises various cellular elements and serves as our immune system's second line of defense. Deviations from its normal composition can have adverse effects on health. At the same time, the oral mucosa in the oral cavity functions as the body's first line of defense, and any anomalies or diseases within it can give rise to both systemic and oral complications. If left untreated, caries can lead to severe tooth damage or extraction, potentially affecting an individual's nutrition and overall health. This review article focuses on the importance of understanding the intricate relationship between blood disorders and oral health. It underscores the profound impact of oral manifestations of blood disorders such as β-thalassemia, sickle cell disease, iron deficiency anemia, leukemia, hemophilia, Plummer-Vinson syndrome, erythroblastosis fetalis, Fanconi anemia, cyclic neutropenia, and acute lymphoblastic leukemia on the overall well-being of an individual.

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“…The use of corticosteroids and androgens provide a partial answer to these hematological complications; however, transfusions and antiinfective therapies are necessary. Curative and definitive treatment in these patients comprises bone-marrow transplantation (2,3).…”

Section: Introductionmentioning

confidence: 99%

Pediatric Dental Care in Fanconi Anemia: A Case Report

Gaitán-Fonseca

Frías-Muñoz

Torre

et al. 2018

Odovtos - Int J Dent Sc

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Fanconi Anemia (FA) is an autosomal-recessive genetic disease that is linked to Chromosome X, which is reported in studies with pancytopenia, congenital malformations, and a predisposition to develop cancer. FA 1,360,000 births, and is a condition that occurs in heterozygous subjects in 0.5% of the population. In Mexico, there are, to our knowledge, no epidemiological data on FA, and it is thought that many cases are underdiagnosed. This document reports the clinical case of a patient diagnosed with FA who the cardinal signs of this rare pathology. The pediatric approach involved was performed with a preventive and restorative approach, in addition to the design and placement of a palatal shutter. After a follow-up of more than 12 months, a significant reduction in the recurrence of infections, such as otitis, tonsillitis, and pharyngitis, was observed, suggesting a positive influence of the use of the obturator. In turn with the latter, there was a lower need for transfusions, which may also be related to control of the foci of the infection. The pediatric approach employed in to patients with FA may have significant repercussions on both quality of life and on their patients’ general systemic condition, although this is scarcely verifiable due to the rarity of this pathology.

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Fanconi Anemia: main oral manifestations

Abstract: ABSTRACT

Cited by 8 publications

References 33 publications

Dental Perspective of Rare Disease of Fanconi Anemia: Case Report with Review

Dental Perspective of Rare Disease of Fanconi Anemia: Case Report with Review

Exploring the Impact of Blood Disorders on Dental Caries

Pediatric Dental Care in Fanconi Anemia: A Case Report

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