Abstract-Crosstalk is one of the bottlenecks for high-speed circuits to increase its rate and density. In order to make tradeoff between complexity and effect of the crosstalk cancellation circuit, a crosstalk cancellation method based on unitary transformation is proposed. In the method, two unitary matrixes are obtained by Singular Value Decomposition (SVD) of coupled transmission lines-channel transmission matrix (CTL-CTM), and then according to the form of the unitary matrixes, the crosstalk canceling circuits are built at both ends of the transmission line, which could transform the CTMes into unit ones and crosstalk would be cancelled out. Circuit simulation results show that at the signaling rate of 5 Gbit/s, jitter performance of eye diagram improves 85% and vertical performance improves 77.5%, which means the method achieves better crosstalk canceling effect with lower circuit cost.