Fare Gebeli̇k Dönemi̇nde Hareketsi̇zli̇k Stresi̇ni̇n Plasenta Ve Yavruya Etki̇leri̇

Semerci, Nihan; Bilici, Gökçen; Yılmaz, Fi̇li̇z Kızılırmak; Cavdar, Zahide; Saçık, Uygar; Kayisli, Umit A.; Erbil, Güven

doi:10.17343/sdutfd.651091

Cited by 1 publication

(2 citation statements)

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“…Inhibition of erythropoiesis, slowing down of hemoglobin synthesis, and an increase in the content of catecholamines can lead to oxygen starvation of tissues and cause stress damage to internal organs. As is known, the pathogenesis of stress lesions is closely related to the activation of fat peroxidation processes [4,6,26], structural changes in cell membranes, including erythrocytes, and, as a result, the development of hemolytic situations in the blood, the degree of which depends both on the strength of the stimulus and on initial cell resistance [27]. Being the rst link in the defense mechanisms of living organisms, the antioxidant system quickly responds to both physiological and biochemical changes, while simultaneously participating and facilitating the activity of adaptation mechanisms.…”

Section: Discussionmentioning

confidence: 99%

“…Immobilization stress is one of the risk factors for developing pathological processes in the body, which may disrupt adaptation processes. As a stress factor, it causes tension in regulatory mechanisms, disruption of vegetative functions reduces the reserve capacity of the body, and inhibits energy processes [3,4]. Short-term exposure to immobilization stress causes erythropenia, a decrease in hemoglobin content and osmotic stability of erythrocytes, and an increase in the number of destroyed erythrocytes in the spleen [5][6][7] against the background of changes in various organs and systems of the body.…”

Section: Introductionmentioning

confidence: 99%

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Impact of Immobilization Stress on Erythropoiesis, Alterations in the Antioxidant System, and Potential Correction with Stevia rebaudiana Bertoni in Rabbit

Karapetyan,

Barseghyan,

Karapetyan

et al. 2024

Preprint

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This study investigates the impact of immobilization stress as a risk factor for pathological processes, with a focus on erythropoiesis and oxidative stress. Additionally, the potential therapeutic effects of Stevia rebaudiana Bertoni in mitigating these stress-induced alterations are explored. Immobilization stress was induced for 30 days, and its effects on erythropoiesis and antioxidant systems were assessed. Stevia rebaudiana Bertoni was administered to evaluate its potential for preventing and correcting the observed negative processes. Prolonged immobilization stress led to disruptions in erythropoiesis, manifested by a delay in proliferative and maturation processes and a moderate decrease in erythrocyte equilibrium. Concurrently, increased stress duration stimulated lipid peroxidation processes and inhibited antioxidant enzyme activity. The use of Stevia rebaudiana Bertoni demonstrated significant positive effects on lipid peroxidation processes and restored the activity of antioxidant enzymes, particularly peroxidase and catalase. Immobilization stress adversely affects erythropoiesis and oxidative balance, contributing to pathological processes. Stevia rebaudiana Bertoni emerges as a promising intervention, displaying the potential to attenuate the negative effects of immobilization stress through its positive influence on erythropoiesis and antioxidant mechanisms.

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Section: Discussionmentioning

confidence: 99%