The present study aims to reveal the reflections of IT applications on the course plan applications of prospective science teachers prepared in accordance with the 5E model and to determine their opinions regarding the impact of these applications on their professional development as teachers. The study includes multiple methods integrating qualitative and quantitative data. At this point, the simple descriptive research method encompassing qualitative and quantitative data was employed. The sample consists of 70 prospective teachers (25 male, 45 female) in their second year of studies at the Faculty of Education, Department of Science Teaching. Information Technologies Opinion Form and Course Plans prepared by the teachers based on the 5E Model were used as data collection tools. The study took place within the scope of the courses titled Computer Skills I-II and Science and Technology Curriculum. Descriptive analysis (frequency, percentage etc.) was used to evaluate the answers to the multiple-choice questions on the Information Technologies Opinion Form. It was also applied for the analysis of open-ended questions and course plans. According to the findings, it was revealed that IT applications were frequently used in the evaluation, engagement and elaboration stages of course plans prepared based on the 5E model and that these plans typically make use of tools such as "Digital Educational Games", "Video Management and Sharing" and "Discussion/Journal Group". The aforementioned IT tools were found to be the ones to be used by prospective teachers during science classes. Furthermore, the study also revealed that prospective teachers deem IT tools to be necessary for teaching science and that IT education contributes to their professional development as teachers.