Farmer's Lung Thermophilic Actinomycetes as a Source of "Farmer's Lung Hay" Antigen

Pepys, J.; Jenkins, P. A.; Festenstein, G. N.; Gregory, P. H.; Lacey, Maureen E.; Skinner, F. A.

doi:10.1016/s0140-6736(63)90398-2

Cited by 292 publications

(69 citation statements)

References 10 publications

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“…The choice of antigenic panel was based on the recognised causes of FL and HP due to moulds at an international [15,16] and local level [11]. The antigenic panel tested included Absidia corymbifera, Eurotium amstelodami, Wallemia sebi, Aspergillus fumigatus, Saccharopolyspora rectivirgula, mesophilic Streptomyces sp.…”

Section: Precipitins Testsmentioning

confidence: 99%

Diagnostic value of serum precipitins to mould antigens in active hypersensitivity pneumonitis

Fenoglio¹,

Reboux²,

Súdre³

et al. 2006

Eur Respir J

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Serum precipitins have a controversial diagnostic value in hypersensitivity pneumonitis (HP). The present authors' objective was to assess their diagnostic value by developing scores from a panel of specific antigens tested by two techniques (electrosyneresis and double diffusion) to discriminate active HP from other interstitial lung diseases.Consecutive patients presenting with a condition for which HP was considered in the differential diagnosis were included in the study. All patients underwent the same standardised diagnostic procedure, including precipitin tests performed in routine conditions. Clinical manifestations, bronchoalveolar lavage and high-resolution computed tomography defined the presence or absence of HP. Receiver-operating characteristic curves and logistic regression were used to develop the serological scores.A total of 122 patients (including 31 cases of HP) were included in the study. Five antigens from the panel were selected for the serological scores (Absidia corymbifera, Eurotium amstelodami, Wallemia sebi, Saccharopolyspora rectivirgula and mesophilic Streptomyces sp.). Electrosyneresis was more discriminative than the double-diffusion technique. Predictive negative values varied 81-88% and predictive positive values varied 71-75% for prevalence of HP 20-35%.In conclusion, serological scores using a panel of relevant antigens may guide both biological and clinical practice in areas of high prevalence of hypersensitivity pneumonitis.

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Section: Precipitins Testsmentioning

confidence: 99%

Diagnostic value of serum precipitins to mould antigens in active hypersensitivity pneumonitis

Fenoglio¹,

Reboux²,

Súdre³

et al. 2006

Eur Respir J

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“…The genus Faenia (26) comprises only one species on the Approved Lists (40), the thermophilic organism Faenia rectivirgula (formerly Micropolyspora rectivirgula [49] ; synonym, Micropolyspora faeni [l]), one of the causative agents of farmer's lung disease (3,25,28,43). A mesophilic species, "Faenia interjecta" (41), has not been validly published and was not available for our studies.…”

mentioning

confidence: 99%

Transfer of Faenia rectivirgula Kurup and Agre 1983 to the Genus Saccharopolyspora Lacey and Goodfellow 1975, Elevation of Saccharopolyspora hirsuta subsp. taberi Labeda 1987 to Species Level, and Emended Description of the Genus Saccharopolyspora

Korn-Wendisch

Kempf

Grund

et al. 1989

International Journal of Systematic Bacteriology

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“…British studies have shown that a thermophilic actinomycete, Micropolyspora (M) faeni, is the main causative agent of farmer's lung (9,10). The microflora of Finnish moldy hay differs from that of British moldy hay (12,13); thus it can be assumed that also the microorganisms liberated in the ambient air causing farmer's lung might be different.…”

mentioning

confidence: 99%

Airborne molds and actinomycetes in the work environment of farmer's lung patients in Finland.

Kotimaa¹,

Husman²,

Terho³

et al. 1984

Scand J Work Environ Health

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KOTIMAA MH, HUSMAN KH, TERHO EO, MUSTONEN MH. Airborne molds and actinomycetes in the work environment of farmer's lung patients in Finland. Scand J Work Environ Health 10 (1984) 115-1 19. Occurrence of molds and actinomycetes in the breathing zone of farmers during the handling of hay, straw, or grain was studied with the use of an Andersen sampler on 35 farms in Finland. On 24 farms there was a person with recently diagnosed farmer's lung disease, and on 11 farms people were free of the disease. The total spore concentration and the concentrations of the spores of Thermoactinomyces (7) vulgaris, Micropolyspora ( M ) faeni, and Aspergillus ( A ) umbrosus were statistically significantly higher on the farms of patients with farmer's lung than on the disease-free farms. The mean proportions of the spores of thermotolerant and thermophilic microbes were greater on the farms of farmer's lung patients than on the reference farms. T vulgaris was the predominant actinomycete species. Both T vulgaris and A umbrosus were found on all farms of farmer's lung patients, but M faeni on only about half of such farms. The findings match the results of previous microbiological analyses of Finnish moldy hay and serological analyses of Finnish farmer's lung patients. It seems that T vulgaris, not Mfaeni, may be the main causative agent of farmer's lung in Finland. The possible etiologic role of A umbrosus requires further investigation. Because the farmers often failed to identify the moldiness of the plant material in contrast to researchers, it might be possible, through training, to improve farmers' ability to identify moldiness.

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Farmer's Lung Thermophilic Actinomycetes as a Source of "Farmer's Lung Hay" Antigen

Cited by 292 publications

References 10 publications

Diagnostic value of serum precipitins to mould antigens in active hypersensitivity pneumonitis

Diagnostic value of serum precipitins to mould antigens in active hypersensitivity pneumonitis

Transfer of Faenia rectivirgula Kurup and Agre 1983 to the Genus Saccharopolyspora Lacey and Goodfellow 1975, Elevation of Saccharopolyspora hirsuta subsp. taberi Labeda 1987 to Species Level, and Emended Description of the Genus Saccharopolyspora

Airborne molds and actinomycetes in the work environment of farmer's lung patients in Finland.

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