Fas Ligand as a Tool for Immunosuppression and Generation of Immune Tolerance

Bohana‐Kashtan, Osnat; Civin, Curt I.

doi:10.1634/stemcells.22-6-908

Cited by 50 publications

(48 citation statements)

References 204 publications

(182 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…37 In other studies Fas-L protein has been implemented in the reduction of allogenic rejection independent of apoptotic induction. 38,39 In our study, the Fas-L protein was upregulated by both the host and injected cells following transplantation, especially at day 10 when CD34 À cells were used. The distributions of Fas-L were found to be located in the nucleus and outer regions of the annulus, consistent with a previous report.…”

mentioning

confidence: 62%

The fate of transplanted xenogeneic bone marrow‐derived stem cells in rat intervertebral discs

Wei

Tao

Chung

et al. 2009

Journal Orthopaedic Research

View full text Add to dashboard Cite

Intervertebral disc degeneration is a major cause and a risk factor for chronic low back pain. The potential of using stem cells to treat disc degeneration has been raised. The aims of our study were to assess whether xenogeneic bone-marrow derived stem cells could survive in a rat disc degeneration model and to determine which cell types, if any, survived and differentiated into disc-like cells. Human bone-marrow derived CD34 þ (hematopoietic progenitor cells) and CD34 À (nonhematopoietic progenitor cells, including mesenchymal stem cells) cells were isolated, fluorescent-labeled, and injected into rat coccygeal discs. The rats were sacrificed at day 1, 10, 21, and 42. Treated discs were examined by histological and immunostaining techniques and compared to control discs. The survival of transplanted cells was further confirmed with a human nuclear specific marker. Fluorescent labeled CD34 À cells were detected until day 42 in the nucleus pulposus of the injected discs. After 3 weeks these cells had differentiated into cells expressing chondrocytic phenotype . In contrast, the fluorescent labeled CD34 þ cells could not be detected after day 21. No fluorescence-positive cells were detected in the noninjected control discs. Further, no inflammatory cells infiltrated the nucleus pulposus, even though these animals had not received immunosuppressive treatment. Our data provide evidence that transplanted human BM CD34 À cells survived and differentiated within the relative immune privileged nucleus pulposus of intervertebral disc degeneration. ß

show abstract

mentioning

confidence: 62%

The fate of transplanted xenogeneic bone marrow‐derived stem cells in rat intervertebral discs

Wei

Tao

Chung

et al. 2009

Journal Orthopaedic Research

View full text Add to dashboard Cite

show abstract

“…In general, the role of FasL is potentially much more complex. For instance, experimental models of lung allogeneic grafts have indicated Fas ligand as a tool for immune suppression and tolerance [15].…”

Section: Introductionmentioning

confidence: 99%

Enhanced expression of Fas Ligand (FasL) in the lower airways of patients with fibrotic interstitial lung diseases (ILDs)

Kopiński¹,

Balicka-Ślusarczyk²,

Dyczek³

et al. 2012

Folia Histochem Cytobiol.

View full text Add to dashboard Cite

Abstract:The exact role of FasL, and particularly its soluble and membrane-bound forms, in the development of chronic ILDs and lung fibrosis has not been extensively explored. We aimed at analyzing membrane-bound FasL expression on alveolar macrophages (AM) and lymphocytes (AL) as well as soluble FasL (sFasL) levels in bronchoalveolar lavage (BAL) from ILDs patients, incl. pulmonary sarcoidosis (PS), hypersensitivity pneumonitis (HP), silicosis, asbestosis, idiopathic pulmonary fibrosis (IPF), nonspecific interstitial pneumonia (NSIP), and healthy subjects (n = 89, 12, 7, 8, 23, 6, 17, respectively

show abstract

“…Studies have clearly demonstrated the ability of FasL to protect allogeneic grafts from immune rejection and to sustain immune tolerance in an immune-privileged site such as the testis (23,24). Our results showed that the level of FasL was up-regulated from the first to the third weeks in vitro and at the second and third weeks in vivo during Sertoli cell infection with UU, while the control group values did not change.…”

Section: Discussionmentioning

confidence: 48%

Expression of IL-1α, IL-6, TGF-β, FasL and ZNF265 During Sertoli Cell Infection by Ureaplasma Urealyticum

et al. 2009

View full text Add to dashboard Cite

show abstract

Fas Ligand as a Tool for Immunosuppression and Generation of Immune Tolerance

Abstract: Abstract

Cited by 50 publications

References 204 publications

The fate of transplanted xenogeneic bone marrow‐derived stem cells in rat intervertebral discs

The fate of transplanted xenogeneic bone marrow‐derived stem cells in rat intervertebral discs

Enhanced expression of Fas Ligand (FasL) in the lower airways of patients with fibrotic interstitial lung diseases (ILDs)

Expression of IL-1α, IL-6, TGF-β, FasL and ZNF265 During Sertoli Cell Infection by Ureaplasma Urealyticum

Contact Info

Product

Resources

About