Fast electroanalytical determination of Cannabidiol and Cannabinol in aqueous solution using Sonogel-Carbon-PEDOT devices

López-Iglesias, David; García-Guzmán, Juan José; Zanardi, Chiara; Palacios-Santander, José María; Aguilera, Laura Cubillana; Pigani, Laura

doi:10.1016/j.jelechem.2020.114591

Cited by 21 publications

(16 citation statements)

References 47 publications

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“…As far as we know, there has been no previous report regarding the electrochemical oxidation mechanism of CBD. By referring to reported works on the oxidation of Δ 9 -THC, the oxidation process of CBD could be assumed to be a phenol-type oxidation mechanism [ 34 , 35 ].…”

Section: Resultsmentioning

confidence: 99%

An Electrochemical Sensor Based on Amino Magnetic Nanoparticle-Decorated Graphene for Detection of Cannabidiol

et al. 2021

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For detection of cannabidiol (CBD)—an important ingredient in Cannabis sativa L.—amino magnetic nanoparticle-decorated graphene (Fe3O4-NH2-GN) was prepared in the form of nanocomposites, and then modified on a glassy carbon electrode (GCE), resulting in a novel electrochemical sensor (Fe3O4-NH2-GN/GCE). The applied Fe3O4-NH2 nanoparticles and GN exhibited typical structures and intended surface groups through characterizations via transmission electron microscopy (TEM), scanning electron microscopy (SEM), X-ray powder diffraction (XRD), vibrating sample magnetometer (VSM), and Raman spectroscopy. The Fe3O4-NH2-GN/GCE showed the maximum electrochemical signal for CBD during the comparison of fabricated components via the cyclic voltammetry method, and was systematically investigated in the composition and treatment of components, pH, scan rate, and quantitative analysis ability. Under optimal conditions, the Fe3O4-NH2-GN/GCE exhibited a good detection limit (0.04 μmol L−1) with a linear range of 0.1 μmol L−1 to 100 μmol L−1 (r2 = 0.984). In the detection of CBD in the extract of C. sativa leaves, the results of the electrochemical method using the Fe3O4-NH2-GN/GCE were in good agreement with those of the HPLC method. Based on these findings, the proposed sensor could be further developed for the portable and rapid detection of natural active compounds in the food, agricultural, and pharmaceutical fields.

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Section: Resultsmentioning

confidence: 99%

An Electrochemical Sensor Based on Amino Magnetic Nanoparticle-Decorated Graphene for Detection of Cannabidiol

et al. 2021

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“…Resulting devices displayed remarkable analytical performance in the quantification of major phytocannabinoids, ascorbic acid, and 4-chloro-3-methylphenol. Furthermore, their surface can be renewed easily and quickly using either electrochemical or mechanical procedures [ 103 , 104 ]. Thus, similar bulk composite devices are promising materials for sensor arrays in electronic tongues, as discussed in the next subsection.…”

Section: Electronic Tongues (E-tongues) Based On Cpsmentioning

confidence: 99%

E-Tongues/Noses Based on Conducting Polymers and Composite Materials: Expanding the Possibilities in Complex Analytical Sensing

Sierra-Padilla

García-Guzmán

López-Iglesias

et al. 2021

Sensors

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Conducting polymers (CPs) are extensively studied due to their high versatility and electrical properties, as well as their high environmental stability. Based on the above, their applications as electronic devices are promoted and constitute an interesting matter of research. This review summarizes their application in common electronic devices and their implementation in electronic tongues and noses systems (E-tongues and E-noses, respectively). The monitoring of diverse factors with these devices by multivariate calibration methods for different applications is also included. Lastly, a critical discussion about the enclosed analytical potential of several conducting polymer-based devices in electronic systems reported in literature will be offered.

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“…Despite recent advances in providing highly efficient chronic painkillers, such as opioids, their adverse side effects remain unaddressed [ 3 ]. For instance, opioids are both addictive and poisonous [ 4 , 8 ]. Thus, seeking alternative chronic painkillers with minimal side effects is highly demanded.…”

Section: Introductionmentioning

confidence: 99%

“…An alternative approach for alleviating chronic pain can be the use of cannabinoids, such as

-tetrahydrocannabinol (

-THC) and cannabidiol (CBD), which are produced from cannabis plants [ 3 , 8 ]. A small quantity of

-THC has other pharmaceutical benefits, particularly as an anti-inflammatory and neuroprotective agent, while a large quantity of

Section: Introductionmentioning

confidence: 99%

“…A small quantity of

-THC has other pharmaceutical benefits, particularly as an anti-inflammatory and neuroprotective agent, while a large quantity of

-THC is psychoactive and addictive [ 8 , 9 ]. On the other hand, a large quantity of CBD is not psychoactive but possesses only pharmaceutical benefits, particularly as a sedative and analgesic [ 8 , 10 ]. Furthermore, purified CBD can alleviate cancer pain, decrease the proliferation of cancer cells, and delay the progression of Alzheimer’s disease [ 8 , 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

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Nanomaterials-Based Electrochemical Δ9-THC and CBD Sensors for Chronic Pain

2023

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Chronic pain is now included in the designation of chronic diseases, such as cancer, diabetes, and cardiovascular disease, which can impair quality of life and are major causes of death and disability worldwide. Pain can be treated using cannabinoids such as Δ9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD) due to their wide range of therapeutic benefits, particularly as sedatives, analgesics, neuroprotective agents, or anti-cancer medicines. While little is known about the pharmacokinetics of these compounds, there is increasing interest in the scientific understanding of the benefits and clinical applications of cannabinoids. In this review, we study the use of nanomaterial-based electrochemical sensing for detecting Δ9-THC and CBD. We investigate how nanomaterials can be functionalized to obtain highly sensitive and selective electrochemical sensors for detecting Δ9-THC and CBD. Additionally, we discuss the impacts of sensor pretreatment at fixed potentials and physiochemical parameters of the sensing medium, such as pH, on the electrochemical performance of Δ9-THC and CBD sensors. We believe this review will serve as a guideline for developing Δ9-THC and CBD electrochemical sensors for point-of-care applications.

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Fast electroanalytical determination of Cannabidiol and Cannabinol in aqueous solution using Sonogel-Carbon-PEDOT devices

Cited by 21 publications

References 47 publications

An Electrochemical Sensor Based on Amino Magnetic Nanoparticle-Decorated Graphene for Detection of Cannabidiol

An Electrochemical Sensor Based on Amino Magnetic Nanoparticle-Decorated Graphene for Detection of Cannabidiol

E-Tongues/Noses Based on Conducting Polymers and Composite Materials: Expanding the Possibilities in Complex Analytical Sensing

Nanomaterials-Based Electrochemical Δ9-THC and CBD Sensors for Chronic Pain

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