Fast enantioseparation by HPLC on a modified carbon nanotube monolithic stationary phase with a pyrenyl aminoglycoside derivative

Guillaume, Yves Claude; André, Claire

doi:10.1016/j.talanta.2013.05.073

Cited by 27 publications

(26 citation statements)

References 16 publications

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“…This PNA-SWCNTs stationary phase was then used to test the ability of SWCNTs for the enantioseparation of ten amino acids. Under optimum conditions, enatioseparation was observed for all of the tested amino acids using PNA-SWCNTs monolithic column [47]. Tryptophan is one of the essential building blocks of proteins and analogues for serotonin and melatonin which improves the mood and sleep [120].…”

Section: Swcnts and Mwcnts For Chiral Separation In Biologicsmentioning

confidence: 99%

“…The separation of the enantiomers of tryptophan has become possible with the aid of some traditional methods such as CE [124], HPLC [125,126], and an electrochemical method [127]. The two enantiomers of tryptophan were partially separated using PNA-SWCNTs as a chiral selector stationary phase [47]. Enantioseparation of tryptophan was, however, more efficient with conventional chromatographic techniques using β-CD as a chiral stationary phase than PNASWCNTs.…”

Section: Swcnts and Mwcnts For Chiral Separation In Biologicsmentioning

confidence: 99%

“…Enantioseparation of tryptophan was, however, more efficient with conventional chromatographic techniques using β-CD as a chiral stationary phase than PNASWCNTs. The two enantiomers of DL-alanine were completely separated using the same chiral stationary phase [47]. Alanine, also, one of the essential building blocks in the biosynthesis of proteins, where the L-form of alanine was found to be one of the essential amino acids in the human genetic code [47], while the D-form exists in bacterial cell walls [128].…”

Section: Swcnts and Mwcnts For Chiral Separation In Biologicsmentioning

confidence: 99%

“…The addition of 1mM of CuSO4 was found to enhance the enantioselectivity of analytes and reduce the analysis time by controlling the dissolution enthalpies and entropies [47]. Amino acids with phenyl rings in their structure such as tryptophan, phenylalanine and tyrosine have long elution times due to an interaction of these phenyl groups with those in SWCNTs and neomycin A [47].…”

Section: Swcnts and Mwcnts For Chiral Separation In Biologicsmentioning

confidence: 99%

“…The use of nonfunctionalized CNTs for enantioseparations has been reported with nano-HPLC that utilises immobilization or encapsulation on polymer monolithic columns [46]. Functionalized CNTs with chiral selectors have been reported to enhance enantioseparations with HPLC [47], GC [37] and CE [32,48]. The use of unmodified and functionalized CNTs for achiral separations with HPLC [49] and CE [50] have also been reported.…”

Section: Introductionmentioning

confidence: 99%

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Application of Carbon Nanotubes in Chiral and Achiral Separations of Pharmaceuticals, Biologics and Chemicals

Hemasa

Naumovski

Maher

et al. 2017

Preprint

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Carbon nanotubes (CNTs) possess unique mechanical, physical, electrical and absorbability properties coupled with their nanometer dimensional scale that renders them extremely valuable for applications in many fields including nanotechnology and chromatographic separation. The aim of this review is to provide an updated overview about the applications of CNTs in chiral and achiral separations of pharmaceuticals, biologics and chemicals. Chiral SWCNTs and MWCNTs have been directly applied for the enantioseparation of pharmaceuticals and biologicals by using them as stationary or pseudostationary phases in chromatographic separation techniques such as high-performance liquid chromatography (HPLC), capillary electrophoresis (CE) and gas chromatography (GC). Achiral MWCNTs have been used for achiral separations as efficient sorbent objects in solid-phase extraction techniques of biochemicals and drugs. Achiral SWCNTs have been applied in achiral separation of biological samples. Achiral SWCNTs and MWCNTs have been also successfully used to separate achiral mixtures of pharmaceuticals and chemicals. Collectively, functionalized CNTs have been indirectly applied in separation science by enhancing the enantioseparation of different chiral selectors whereas, non-functionalized CNTs have shown efficient capabilities for chiral separations by using techniques such as encapsulation or immobilization in polymer monolithic columns.

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Section: Swcnts and Mwcnts For Chiral Separation In Biologicsmentioning

confidence: 99%

Section: Swcnts and Mwcnts For Chiral Separation In Biologicsmentioning

confidence: 99%

Section: Swcnts and Mwcnts For Chiral Separation In Biologicsmentioning

confidence: 99%

Section: Swcnts and Mwcnts For Chiral Separation In Biologicsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Application of Carbon Nanotubes in Chiral and Achiral Separations of Pharmaceuticals, Biologics and Chemicals

Hemasa

Naumovski

Maher

et al. 2017

Preprint

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Rational design of highly enantioselective composite voltammetric sensors using a computationally predicted chiral modifier

et al. 2022

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The use of chiral modifiers is among the simplest and most popular strategies for synthesizing enantioselective voltammetric sensors that are applied for the analysis and discrimination of enantiomerical drugs in various media. The type and structure of the chiral modifier are the key factors for the creation of enantioselectivity to a specified analyte. We suggest a novel approach to the prediction of the quality of a chiral modifier for preparing highly enantioselective sensors. The suggested approach is based on the molecular mechanics modeling of the adsorption of analyte enantiomers on chiral modifiers and on the comparison of the corresponding adsorption energies (ΔEads). The efficiency of our approach is demonstrated using the example of cyclodextrins and chiral single‐wall carbon nanotubes as chiral modifiers, and a wide range of chiral analytes. We found that the experimental enantioselectivity (ϑexp) measured using voltammetry linearly correlates with ΔEads. The suggested approach also showed good predictive power in application to enantioselective chromatography, which further validates its general applicability.

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Evaluation of chiral separation based on bovine serum albumin–conjugated carbon nanotubes as stationary phase in capillary electrochromatography

et al. 2020

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In this work, we utilized adsorbed BSA and multiwalled carbon nanoparticles (BSA/MWCNTs) as a stationary phase in open tubular (OT) capillary for separation of chiral drugs. (3-Aminopropyl)triethoxysilane was used to assist fabrication of BSA/MWCNTscoated OT column by covalent bonding. Incorporation of MWCNTs nanomaterials into a polymer matrix could increase the phase ratio and take advantage of the easy preparation of an open tubular CEC column. SEM was carried out to characterize the BSA/MWCNTs OT columns. The electrochromatographic performance of the OT columns was evaluated by separation of ketoprofen, ibuprofen, uniconazole, and hesperidin. The effects of MWCNTs concentration, background solution pH and concentration, and applied voltage on separation were investigated. Chiral separations of ketoprofen, ibuprofen, uniconazole, and hesperidin were achieved using the BSA/MWCNTs-coated OT column with resolutions of 24.20, 12.81, 1.50, and 1.85, respectively. Their optimas were found in the 30 mM phosphate buffers at pH 5.0, 6.5, 7.0, and 6.5, respectively. In addition, the columns demonstrated good repeatability and stability with the run-to-run, day-today , and batch-to-batch RSDs of migration times less than 3.5%.

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Fast enantioseparation by HPLC on a modified carbon nanotube monolithic stationary phase with a pyrenyl aminoglycoside derivative

Cited by 27 publications

References 16 publications

Application of Carbon Nanotubes in Chiral and Achiral Separations of Pharmaceuticals, Biologics and Chemicals

Application of Carbon Nanotubes in Chiral and Achiral Separations of Pharmaceuticals, Biologics and Chemicals

Rational design of highly enantioselective composite voltammetric sensors using a computationally predicted chiral modifier

Evaluation of chiral separation based on bovine serum albumin–conjugated carbon nanotubes as stationary phase in capillary electrochromatography

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