Fast gas chromatography negative chemical ionization tandem mass spectrometry of explosive compounds using dynamic collision-induced dissociation

Collin, Olivier; Zimmermann, Carolyn M.; Jackson, Glen P.

doi:10.1016/j.ijms.2008.10.009

Cited by 32 publications

(10 citation statements)

References 30 publications

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“…The combination of fast GC method with dynamic collisioninduced dissociation (DCID) offered a method for analysis of explosives with detection limits between 0.5 and 5 pg. This evokes statement NCI-DCID-tandem MS being at least comparable if not superior to other MS techniques (Collin, Zimmermann, & Jackson, 2009).…”

Section: Spectrometry For Explosivesmentioning

confidence: 99%

Ion spectrometric detection technologies for ultra‐traces of explosives: A review

Mäkinen

Nousiainen

Sillanpää

2011

Mass Spectrometry Reviews

147

102

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In recent years, explosive materials have been widely employed for various military applications and civilian conflicts; their use for hostile purposes has increased considerably. The detection of different kind of explosive agents has become crucially important for protection of human lives, infrastructures, and properties. Moreover, both the environmental aspects such as the risk of soil and water contamination and health risks related to the release of explosive particles need to be taken into account. For these reasons, there is a growing need to develop analyzing methods which are faster and more sensitive for detecting explosives. The detection techniques of the explosive materials should ideally serve fast real-time analysis in high accuracy and resolution from a minimal quantity of explosive without involving complicated sample preparation. The performance of the in-field analysis of extremely hazardous material has to be user-friendly and safe for operators. The two closely related ion spectrometric methods used in explosive analyses include mass spectrometry (MS) and ion mobility spectrometry (IMS). The four requirements-speed, selectivity, sensitivity, and sampling-are fulfilled with both of these methods.

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Section: Spectrometry For Explosivesmentioning

confidence: 99%

Ion spectrometric detection technologies for ultra‐traces of explosives: A review

Mäkinen

Nousiainen

Sillanpää

2011

Mass Spectrometry Reviews

147

102

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“…Kromatogram total ion chromatogram (TIC) pada mode deteksi scan menghasilkan luas puncak gabungan seluruh spektrum massa yang sebanding dengan konsentrasi analit, namun puncak baku pembanding internal dan eksternal tidak terpisah sempurna, maka untuk mengatasinya digunakan mode ion selektif (SIM) yang dapat memisahkan puncak analit (Gambar 2). SIM waktu siklusnya lebih pendek dari pada mode deteksi scan, akurasi dan presisinya lebih baik sehingga analisis kuantitatif menjadi lebih optimal (Collin et al 2009).…”

Section: Metode Analisisunclassified

VALIDASI MODIFIKASI METODE WEIßHAAR UNTUK ANALISIS 3-MCPD ESTER DALAM MINYAK GORENG SAWIT [Validation of Modified Weißhaar’s Method for 3-MCPD Esters Analysis in Palm Oil]

Lanovia

Andarwulan

Hariyadi

2014

jtip

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The 3-monochloropropane-1,2-diol (3-MCPD) and 3-MCPD esters were found in any type of refined vegetable oil -mostly produced during the refining process-and recognized as emerging food contaminants. Several analytical methods have been developed and one of which was a Weißhaar's method. The study aims to validate the modified Weißhaar's method for analysis of 3-MCPD and 3-MCPD esters in refined palm oil. Ion fragments were used for identification and quantification of 3-MCPD and 3-MCPD-d5. 3-MCPD was determined by GC-MS after released from its ester by transesterification with sodium methoxide and derivatized with phenylboronic acid. The validation showed that liniarity response (r=0.994) was observed from a linear regression by using external standard and internal standard at a concentration range of 0.008 and 0.377 µg mL -1 . The LOD of the validated method was 0.06 µg g -1 while its LOQ was 0.20 µg g -1 , precision (relative standard deviation, RSD) was 6.16%, and accuracy (as percentage of recovery) was in the range of 95.83-113.27%. This results indicated that the modified method was valuable and sensitive for detection of 3-MCPD and 3-MCPD esters. Using the validated method, 3-MCPD esters content of a commercial palm oil sample was determined and calculated as the difference between total 3-MCPD and free 3-MCPD, which was 13.24 µg g -1 . Total 3-MCPD content of several palm oils were at a concentration range of 13.94-34.52 µg g -1 . These results also showed that there was a correlation between 3-MCPD with diacylglyceride (DAG). Samples with DAG content gave a high test results of 3-MCPD with a coefficient of correlation of r=0.752. ABSTRAKSenyawa 3-monochloropropane-1,2-diol (3-MCPD) dan esternya merupakan kontaminan yang umumnya terbentuk pada proses pengolahan pangan. Kontaminan ini termasuk food emerging yang berpotensi mempengaruhi kesehatan manusia. Beberapa metode analisis telah dikembangkan untuk penetapan kadar 3-MCPD dan esternya dan salah satunya adalah metode Weißhaar yang digunakan untuk menguji minyak safflower. Penelitian ini bertujuan untuk memvalidasi metode analisis Weißhaar yang dimodifikasi dan metode ini digunakan untuk minyak goreng sawit. 3-MCPD ester dibebaskan dari esternya oleh natrium metoksida secara transesterifikasi kemudian 3-MCPD bebas diderivatisasi dengan phenylboronic acid dan diidentifikasi secara GC-MS dengan menggunakan fragmen ion. Validasi metode analisis yang dilakukan memberikan hasil sebagai berikut: dari persamaan regresi y= 0.076x + 0.005, y adalah rasio area baku pembanding eksternal dan internal, x adalah konsentrasi baku pembanding eksternal, didapatkan linearitas yang ditunjukkan oleh koefesien korelasi (r) 0.994 pada rentang kerja 0.008-0.377 µg mL -1 ; batas deteksi pada 0.06 µg g -1 , batas kuantitasi pada 0.20 µg g -1 ; presisi dinyatakan sebagai koefisien variasi sebesar 5.89%; akurasi dihitung sebagai persen rekoveri dengan nilai 95.83-113.27%. Hasil validasi metode analisis ini memenuhi kriteria yang telah dipersyaratkan. Kadar 3-MCPD ester dihitung se...

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“…The coupling of fast GC with NCI-MS/MS was utilized for the analysis of explosives [15], in forensic toxicology for analysis of cannabinoids in blood [16] and hypnotic agents [17], and fast GC with narrow-bore column (0.15 mm I.D.) and MS detector in NCI mode was introduced by Hu´sˇkova´et al [18] for analysis of pesticide residues.…”

Section: Introductionmentioning

confidence: 99%

Survey of low-level endocrine disrupting pesticides in food matrices in Slovakia

Hrouzková

Matisová

Andraščíková

et al. 2012

International Journal of Environmental Analytical Chemistry

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The search on endocrine disrupting chemicals (EDCs) in non-fatty food was evaluated. A fast, high-throughput, accurate, multiresidue method for the analysis of selected EDC pesticides in fruit and vegetable food samples was developed. The QuEChERS technique was used for sample preparation. Fast GC-MS was performed with a narrow-bore capillary column and a quadrupole benchtop detector with electron ionization (EI) and negative chemical ionization (NCI). A part of the work was devoted to the comparison of NCI versus EI approach concerning the sensitivity of detection and to the study of selectivity enhancement in NCI mode. Matrix-matched standard solutions were utilized for calibration. The methods validation was performed. Fortification studies at 1, 5, 10 and 250 mg kg À1 for 35 pesticides in EI mode and 0.1, 1, 5 and 250 mg kg À1 for 28 pesticides in NCI mode were performed. Average recoveries for each fortification level ranged from 70 to 110% with 480% of recoveries between 90 and 110%. Limits of quantification (LOQs) were established at 5 mg kg À1 for EI and at 1 mg kg À1 for NCI mode, which is lower than the lowest maximum residue level (MRL) value set by the European Commission in fruit and vegetables. The developed and validated fast GC-MS method was successfully applied to the search of EDC pesticides at ultratrace concentration level in real fruit and vegetable samples in Slovakia. Thirty-four samples of 20 different commodities were analyzed. Seven samples contained residues of three or more EDCs pesticides.

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Fast gas chromatography negative chemical ionization tandem mass spectrometry of explosive compounds using dynamic collision-induced dissociation

Cited by 32 publications

References 30 publications

Ion spectrometric detection technologies for ultra‐traces of explosives: A review

Ion spectrometric detection technologies for ultra‐traces of explosives: A review

VALIDASI MODIFIKASI METODE WEIßHAAR UNTUK ANALISIS 3-MCPD ESTER DALAM MINYAK GORENG SAWIT [Validation of Modified Weißhaar’s Method for 3-MCPD Esters Analysis in Palm Oil]

Survey of low-level endocrine disrupting pesticides in food matrices in Slovakia

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