Fast image–charge calculations for multi-particle simulations in FT-ICR analyzer cells of arbitrary geometry

Driver, Joshua A.; Харченко, А. В.; Heeren, Ron M. A.; Amster, I. Jonathan

doi:10.1016/j.ijms.2014.07.038

Cited by 6 publications

(2 citation statements)

References 33 publications

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“…The sideband amplitudes are determined by the amplitude of the frequency modulation of ion drift motion in the trapping field. In addition to time-dependent drift motion due to ion trapping, an additional frequency variable shift is possible due to the action of the intrinsic electric field of the space charge, and also as a result of interaction with induced "image" charges on the electrodes (Driver et al, 2015). In these cases, the additional shift is nonstatic in nature.…”

Section: Dynamic Ion Motion Compact Ion Bunch (Single Ion)mentioning

confidence: 99%

“…In practice, to establish coherent ion motion in a magnetic field over a suitable period of time, while avoiding ion leakage, ions are confined (or trapped) inside the ICR cell (trap or mass analyzer) using static electric (trapping) fields (Breitenfeldt et al, 2008;Guan & Marshall, 1995;Marshall, 2000). Other electric fields, such as those generated by (image) charge fields induced on surrounding electrodes, and the space charge fields, influence the rotating ions during ICR cell confinement (Driver et al, 2015;Ledford et al, 1984aLedford et al, , 1984bMasselon et al, 2002;Taylor & Amster, 2003;Wong & Amster, 2007). The latter two fields are from all ions present in the ICR cell, whether having the same or different m/z values.…”

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confidence: 99%

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Fourier transform ion cyclotron resonance mass spectrometry at the true cyclotron frequency

Nagornov

Tsybin

Nicol

et al. 2021

Mass Spectrometry Reviews

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Ion cyclotron resonance (ICR) cells provide stability and coherence of ion oscillations in crossed electric and magnetic fields over extended periods of time. Using the Fourier transform enables precise measurements of ion oscillation frequencies. These precisely measured frequencies are converted into highly accurate mass-to-charge ratios of the analyte ions by calibration procedures. In terms of resolution and mass accuracy, Fourier transform ICR mass spectrometry (FT-ICR MS) offers the highest performance of any MS technology. This is reflected in its wide range of applications. However, in the most challenging MS application, for example, imaging, enhancements in the mass accuracy of fluctuating ion fluxes are required to continue advancing the field. One approach is to shift the ion signal power into the peak corresponding to the true cyclotron frequency instead of the reduced cyclotron frequency peak. The benefits of measuring the true cyclotron frequency include increased tolerance to electric fields within the ICR cell, which enhances frequency measurement precision. As a result, many attempts to implement this mode of FT-ICR MS operation have occurred. Examples of true cyclotron frequency measurements include detection of magnetron inter-harmonics of the reduced cyclotron frequency (i.e., the sidebands), trapping fieldfree (i.e., screened) ICR cells, and hyperbolic ICR cells with quadrupolar ion detection. More recently, ICR cells with spatially distributed ion clouds have demonstrated attractive performance characteristics for true cyclotron frequency ion detection. Here, we review the corresponding developments in FT-ICR MS over the past 40 years.

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Section: Dynamic Ion Motion Compact Ion Bunch (Single Ion)mentioning

confidence: 99%

mentioning

confidence: 99%

Fourier transform ion cyclotron resonance mass spectrometry at the true cyclotron frequency

Nagornov

Tsybin

Nicol

et al. 2021

Mass Spectrometry Reviews

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Multiparticle Simulations of Quadrupolar Ion Detection in an Ion Cyclotron Resonance Cell with Four Narrow Aperture Detection Electrodes

Driver

Nagornov

Kozhinov

et al. 2017

J. Am. Soc. Mass Spectrom.

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The current paradigm in FT-ICR cell design is to approximate the ideal three-dimensional quadratic trapping potential as closely as possible to maintain ion cloud spatial coherence and achieve long transients, either with hyperbolically shaped electrodes, shimming electrodes, or by dynamic harmonization. In sharp contrast, the FT-ICR analyzer cell with four narrow aperture detection electrodes (NADEL) introduces significant anharmonic terms to the trapping potential. This analyzer cell is capable of quadrupolar detection by which one can measure a signal that is close to the unperturbed cyclotron frequency. This is far less sensitive to trapping potential and space charge shifts than the reduced cyclotron frequency measured in conventional ICR cells. The quadrupolar mode of ion detection in NADEL cells has been examined previously by SIMION simulations of ion clouds with up to 500 ions per simulation. Here, the behavior of the NADEL analyzer cell is examined through particle-in-cell (PIC) simulations, which allows us to examine the behavior of large populations (tens of thousands) of ions with space charge considerations, and to calculate the induced charge on the NADEL detection electrodes, and thus the transient signal. PIC simulations confirm a unique spatial distribution of the ions, with a coherent motion that results in long transient signals. Dependence of the ion cloud and image current signal on cell design, ion energy, and magnetron radius are examined. Coalescence effects are compared with those found in a dynamically harmonized cell. The insensitivity of the measured cyclotron frequency to space-charge is demonstrated both with simulations and experimentally. Graphical Abstract ᅟ.

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Fundamentals, strengths, and future directions for Fourier transform ion cyclotron resonance mass spectrometry

Easterling

Agar

2019

Fundamentals and Applications of Fourier Transform Mass Spectrometry

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Fast image–charge calculations for multi-particle simulations in FT-ICR analyzer cells of arbitrary geometry

Cited by 6 publications

References 33 publications

Fourier transform ion cyclotron resonance mass spectrometry at the true cyclotron frequency

Fourier transform ion cyclotron resonance mass spectrometry at the true cyclotron frequency

Multiparticle Simulations of Quadrupolar Ion Detection in an Ion Cyclotron Resonance Cell with Four Narrow Aperture Detection Electrodes

Fundamentals, strengths, and future directions for Fourier transform ion cyclotron resonance mass spectrometry

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