Fast low temperature ultrasonic synthesis and injection ready preparation of carrier free 17‐I‐123‐heptadecanoic acid

Mertens, John; Vanryckeghem, W.; Bossuyt, Axel; Winkel, P. Van den; Vandendriessche, René

doi:10.1002/jlcr.2580210908

Cited by 12 publications

(1 citation statement)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For preparation of carrier-free 17-123 J-heptadecanoic acid ( 123 J-HDA) the method described by Mertens et al [9] was slightly modified. In brief, 123 J-NaJ solution (Cygne, Eindhoven, The Netherlands) was evaporated to dryness.…”

Section: Preparation Of Radioactively Labelled Fatty Acidsmentioning

confidence: 99%

Myocardial fatty acid metabolism during acute cardiac allograft rejection

et al. 1997

View full text Add to dashboard Cite

Fatty acids are promptly taken up, metabolised and eliminated by healthy cardiomyocytes. Cardiomyopathy, coronary heart disease and chronic rejection are known to be associated with an impaired fatty acid metabolism. It was the aim of this study to investigate fatty acid metabolism in a rat heart transplant model and to correlate scintigraphic findings with histological changes. After right-side nephrectomy of Lewis recipients Brown Norway cardiac allografts were anastomosed to the renal vessels. Animals were given no immunosuppression. The metabolism of carrier-free 17-123 jodo-heptadecanoic acid (123J-HDA) with a specific activity of > 2 x 10(17) Bq/ml was scintigraphically measured between days 1 and 11. An increase in the grade of rejection was observed over time. Fifty-six frames of 30 s duration each were recorded. For the region of interest (native heart, transplanted heart, left kidney) frames 10-56 were superimposed, time-activity curves generated and monoexponentially fitted. Furthermore, elimination half-life and intercepts were calculated. Following scintigraphic evaluation the animals were killed and graft as well as native hearts excised for histological examination. The uptake of the tracer identified severe grades of rejection. Elimination half-life of the tracer was twice as long from hearts with mild rejection and more than 14 times as long in severe rejection compared with no rejection. Elimination half-life and amplitude did not permit discrimination between grades 1, 2 and 3 a, but significantly decreased in groups 3 b and 4. This method therefore seems to be a valuable tool for the noninvasive detection of severe acute cardiac allograft rejection. Since fatty acid metabolism is clearly stress-dependent it remains to be seen whether this method allows detection of earlier rejection in loaded hearts.

show abstract

Section: Preparation Of Radioactively Labelled Fatty Acidsmentioning

confidence: 99%

Myocardial fatty acid metabolism during acute cardiac allograft rejection

et al. 1997

View full text Add to dashboard Cite

show abstract

Copper catalyzed radioiodination of 3-iodotyrosine and 4-iodophenyl alanine

Farah

Farouk

1997

J Label Compd Radiopharm

View full text Add to dashboard Cite

The factors affecting the yield of the copper catalyzed labelling of 3‐iodotyrosine and 4‐iodophenyl alanine such as pH of the medium, catalyst and substrate concentrations and solvent effects are described. The reaction is assumed to take place via an intermediate organo‐copper complex which favours the exchange between radioiodine and the inactive iodine in the iodocompound. The reducing agents ascorbic acid, stannous chloride or sodium metabisulphite are added to the cuprous chloride catalyzed reaction to prevent the oxidation of Cu (I) to Cu (II) in order to decrease side products formation and improve the labelling yield. Kinetics indicated a second order reaction with an activation energy of 9.6 Kcal/mole for 3‐iodotyrosine and 12.2 Kcal/mole for 4‐iodophenyl alanine. The stronger 4‐iodophenyl C‐I bond favours para‐iodination in the preparation of radioiodinated monoclonal antibodies. © 1997 John Wiley & Sons, Ltd.

show abstract

Some Synthetic Uses of Halides

Hoyle¹

2009

Patai's Chemistry of Functional Groups

View full text Add to dashboard Cite

Introduction Functional Group Interconversion of Halides Carbon–Carbon Bond Formation Using Halides Preparation of Heterocyclic Compounds by C  Y Bond Formation Rearrangement of Halides Acknowledgements

show abstract

Fast low temperature ultrasonic synthesis and injection ready preparation of carrier free 17‐I‐123‐heptadecanoic acid

Cited by 12 publications

References 8 publications

Myocardial fatty acid metabolism during acute cardiac allograft rejection

Myocardial fatty acid metabolism during acute cardiac allograft rejection

Copper catalyzed radioiodination of 3-iodotyrosine and 4-iodophenyl alanine

Some Synthetic Uses of Halides

Contact Info

Product

Resources

About