Fast one-pot microwave-assisted green synthesis of highly fluorescent plant-inspired S,N-self-doped carbon quantum dots as a sensitive probe for the antiviral drug nitazoxanide and hemoglobin

Qandeel, Nermeen A.; El-Masry, Amal A.; Eid, Manal; Moustafa, Mohamed A.; El-Shaheny, Rania

doi:10.1016/j.aca.2022.340592

Cited by 43 publications

(26 citation statements)

References 50 publications

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“…FT‐IR spectra were also recorded to elucidate the functional groups at the surface of the prepared N‐doped CQDs. As shown in (Figure 2e), the peaks appeared at 3430, 2100, 1700, 1660, 1265, and 1035 cm −1 correspond to O–H/N–H, C–N, C=O, C=C, C–O of –C–OH, and S=O groups, respectively [20, 39, 40]. The prepared N‐CQDs were also subjected to an elemental analysis using EDX to determine their composition and validate the level of nitrogen doping.…”

Section: Resultsmentioning

confidence: 99%

Citrus/urea nitrogen‐doped carbon quantum dots as nanosensors for vanillin determination in infant formula and food products via factorial experimental design fluorimetry and smartphone

El Hamd,

El‐Maghrabey,

Almawash

et al. 2023

Luminescence

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Vanillin is a flavouring agent that is prohibited for use in infant food products with ages lower than 6 months. Excessive vanillin usage could lead to eating disorders, nausea, headache, and vomiting. Therefore, it is essential to control the contents of vanillin in food samples, especially in infant formula. Here, we developed a highly sensitive nanosensor for vanillin based on using green synthesized highly fluorescent (QY = 29.5%) N‐doped carbon quantum dots (N‐CQDs) as a turn‐off fluorescent nanoprobe. The N‐doped CQDs synthesis was adopted using citrus bulb squeeze extract and the commonly used fertilizer, urea, as substrates. After mixing with vanillin, the fluorescence of the N‐CQDs was largely quenched in a vanillin concentration‐dependent manner. The sensing conditions were optimized by quality‐by‐design using a two‐level full factorial design (22 FFD). The N‐doped CQDs could detect vanillin in the range 0.1–12.0 μg/ml with a limit of detection of 0.013 μg/ml. Next, a smartphone imaging‐based assay combined with a UV chamber was adopted and applied for vanillin determination. This simple detection technique showed sensitivity similar to that of the conventional fluorimetric method. Both conventional and smartphone‐based methods were successfully applied for the determination of vanillin in infant milk formula and biscuits and could detect real vanillin concentrations in the analyzed samples with high % recoveries (94.5% to 105.5%). At last, the biocompatibility of the newly synthesized N‐CQDs was tested, and it was found to be an excellent candidate for cancer cell imaging.

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Section: Resultsmentioning

confidence: 99%

Citrus/urea nitrogen‐doped carbon quantum dots as nanosensors for vanillin determination in infant formula and food products via factorial experimental design fluorimetry and smartphone

El Hamd,

El‐Maghrabey,

Almawash

et al. 2023

Luminescence

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“…16 Carbon dots have been widely used as alternative luminescent nanoprobes for quantitative determination of analytes previously assayed by uorescent dyes or semiconductor quantum dots due to their excellent photostability, tunable emission wavelength, good water-solubility, and low elemental toxicity. 17,18 Regarding synthesis of luminescent carbon quantum dots; many procedures and methodologies have been developed for this aim, these include: carbonization, 19,20 chemical and electrochemical oxidation, [21][22][23][24] hydrothermal cutting methodologies, 25 microwave-assisted methodology, 26 and others. Whereas, the majority of the previous mentioned methods do not provide a large yield and need expensive equipment hence they are not chosen.…”

Section: Nifuroxazidementioning

confidence: 99%

“…30 In addition, N, S-doped carbon dots were used as sensitive probe for hemoglobin determination. 26 Moreover, stable nitrogen and sulfur co-doped carbon dots were used for selective folate sensing, in vivo imaging and drug delivery. 31 In this study, a straightforward one-step hydrothermal approach was used to create nitrogen and sulphur co-doped quantum dots (NSC-dots) from L-cysteine and citric acid.…”

Section: Nifuroxazidementioning

confidence: 99%

White sustainable luminescent determination of nifuroxazide using nitrogen–sulphur co-doped carbon quantum dots nanosensor in bulk and various pharmaceutical matrices

Elnaggar,

El-Yazbi,

Belal

et al. 2023

RSC Adv.

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“…Carbon dots belong to zero-dimensional materials with quasi-spherical shapes, and their sizes are below 10 nm [ 2 , 3 , 4 ]. They have had considerable attention in recent years due to their attractive characteristics such as excellent water dispersibility, multicolor fluorescence emissions, prolonged colloidal durability in aqueous media, excellent photostability, good biocompatibility, cost-effective production, unique chemical inertness, and tunable surface functionalities [ 5 , 6 , 7 , 8 , 9 ]. Moreover, the synthesis process of carbon dots does not involve any hazardous heavy metals; hence, it is environmentally friendly.…”

Section: Introductionmentioning

confidence: 99%

Natural Nitrogen-Doped Carbon Dots Obtained from Hydrothermal Carbonization of Chebulic Myrobalan and Their Sensing Ability toward Heavy Metal Ions

Atchudan

Perumal

Edison

et al. 2023

Sensors

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Chebulic Myrobalan is the main ingredient in the Ayurvedic formulation Triphala, which is used for kidney and liver dysfunctions. Herein, natural nitrogen-doped carbon dots (NN-CDs) were prepared from the hydrothermal carbonization of Chebulic Myrobalan and were demonstrated to sense heavy metal ions in an aqueous medium. Briefly, the NN-CDs were developed from Chebulic Myrobalan by a single-step hydrothermal carbonization approach under a mild temperature (200 °C) without any capping and passivation agents. They were then thoroughly characterized to confirm their structural and optical properties. The resulting NN-CDs had small particles (average diameter: 2.5 ± 0.5 nm) with a narrow size distribution (1–4 nm) and a relatable degree of graphitization. They possessed bright and durable fluorescence with excitation-dependent emission behaviors. Further, the as-synthesized NN-CDs were a good fluorometric sensor for the detection of heavy metal ions in an aqueous medium. The NN-CDs showed sensitive and selective sensing platforms for Fe3+ ions; the detection limit was calculated to be 0.86 μM in the dynamic range of 5–25 μM of the ferric (Fe3+) ion concentration. Moreover, these NN-CDs could expand their application as a potential candidate for biomedical applications and offer a new method of hydrothermally carbonizing waste biomass.

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Fast one-pot microwave-assisted green synthesis of highly fluorescent plant-inspired S,N-self-doped carbon quantum dots as a sensitive probe for the antiviral drug nitazoxanide and hemoglobin

Cited by 43 publications

References 50 publications

Citrus/urea nitrogen‐doped carbon quantum dots as nanosensors for vanillin determination in infant formula and food products via factorial experimental design fluorimetry and smartphone

Citrus/urea nitrogen‐doped carbon quantum dots as nanosensors for vanillin determination in infant formula and food products via factorial experimental design fluorimetry and smartphone

White sustainable luminescent determination of nifuroxazide using nitrogen–sulphur co-doped carbon quantum dots nanosensor in bulk and various pharmaceutical matrices

Natural Nitrogen-Doped Carbon Dots Obtained from Hydrothermal Carbonization of Chebulic Myrobalan and Their Sensing Ability toward Heavy Metal Ions

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