Fast self-assembly of silver nanoparticle monolayer in hydrophobic environment and its application as SERS substrate

Leiterer, Christian; Zopf, David; Seise, Barbara; Jahn, F.; Weber, Karina; Popp, Jürgen; Cialla‐May, Dana; Fritzsche, Wolfgang

doi:10.1007/s11051-014-2467-2

Cited by 22 publications

(8 citation statements)

References 31 publications

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“…The hydrophobic substrate enhanced the SERS signals by 3 times compared to the hydrophilic surfaces, which improved the sensitivity of SERS-based detections. Leiterer et al presented a straightforward way to obtain the monolayer assembled by silver nanoparticles, in which Ag NPs were coated with a hydrophobic shell to induce self-assembly without any other surfactants . The SERS hot spots generated with the assistance of hydrophobic nanoparticles could enhance the SERS signals.…”

Section: Platforms For Sers-based Immunoassaymentioning

confidence: 99%

“…Leiterer et al presented a straightforward way to obtain the monolayer assembled by silver nanoparticles, in which Ag NPs were coated with a hydrophobic shell to induce self-assembly without any other surfactants. 171 The SERS hot spots generated with the assistance of hydrophobic nanoparticles could enhance the SERS signals. Similarly, Hou et al synthesized hydrophobic Ag NPs in the presence of tri-n-octylphosphine sulfide.…”

Section: Hydrophobic Sers Substratesmentioning

confidence: 99%

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SERS-Activated Platforms for Immunoassay: Probes, Encoding Methods, and Applications

et al. 2017

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Owing to their excellent multiplexing ability, high sensitivity, and large dynamic range, immunoassays using surface-enhanced Raman scattering (SERS) as the readout signal have found prosperous applications in fields such as disease diagnosis, environmental surveillance, and food safety supervision. Various ever-increasing demands have promoted SERS-based immunoassays from the classical sandwich-type ones to those integrated with fascinating automatic platforms (e.g., test strips and microfluidic chips). As recent years have witnessed impressive progress in SERS immunoassays, we try to comprehensively cover SERS-based immunoassays from their basic working principles to specific applications. Focusing on several basic elements in SERS immunoassays, typical structures of SERS nanoprobes, productive optical spectral encoding strategies, and popular immunoassay platforms are highlighted, followed by their representative biological applications in the last 5 years. Moreover, despite the vast advances achieved to date, SERS immunoassays still suffer from some annoying shortcomings. Thus, proposals on how to improve the SERS immunoassay performance are also discussed, as well as future challenges and perspectives, aiming to give brief and valid guidelines for choosing suitable platforms according to particular applications.

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Section: Platforms For Sers-based Immunoassaymentioning

confidence: 99%

Section: Hydrophobic Sers Substratesmentioning

confidence: 99%

SERS-Activated Platforms for Immunoassay: Probes, Encoding Methods, and Applications

et al. 2017

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“…Thus, the interaction of the water-insoluble analytes with the metallic surface could be improved, and the SERS signal could be further amplified because more molecules are in the near field of the plasmonic surface. Consequently, a number of research studies have been published to generate hydrophobic surfaces. ,− One common surface functionalization to achieve hydrophobic surfaces is by combining micro/nanostructures using top-down techniques, such as lithography and plasma treatment. ,− However, these techniques require complex preparation steps and are often expensive and time consuming. The hierarchically-designed 3D flower-like silica–silver composite nanostructures presented in this study not only function as SERS templates but also provide highly hydrophobic surfaces, which were investigated through contact angle measurements of the nonmetalized composite nanostructure (135 PE-ALD cycles) and the 50 nm silver metallized composite nanostructure depicted in Figure b.…”

Section: Resultsmentioning

confidence: 99%

Hierarchically-Designed 3D Flower-Like Composite Nanostructures as an Ultrastable, Reproducible, and Sensitive SERS Substrate

Yüksel

Ziegler

Goerke

et al. 2017

ACS Appl. Mater. Interfaces

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Surface-enhanced Raman spectroscopy (SERS) is an attractive tool in the analytical sciences due to its high specificity and sensitivity. Because SERS-active substrates are only available as two-dimensional arrays, the fabrication of three-dimensional (3D) nanostructures allows for an increased number of hot spots in the focus volume, thus further amplifying the SERS signal. Although a great number of fabrication strategies for powerful SERS substrates exist, the generation of 3D nanostructures with high complexity and periodicity is still challenging. For this purpose, we report an easy fabrication technique for 3D nanostructures following a bottom-up preparation protocol. Enzymatically generated silver nanoparticles (EGNPs) are prepared, and the growth of hierarchically-designed 3D flower-like silica-silver composite nanostructures is induced by applying plasma-enhanced atomic layer deposition (PE-ALD) on the EGNPs. The morphology of these nanocomposites can be varied by changes in the PE-ALD cycle number, and a flower height of up to 10 μm is found. Moreover, the metallized (e.g., silver or gold) 3D nanostructures resulting from 135 PE-ALD cycles of silica creation provide highly reproducible SERS signals across the hydrophobic surface. Within this contribution, the morphological studies, optical properties, as well as the SERS response of these metallized silica-silver composite nanostructures applying vitamin B2 as a model analyte are introduced.

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“…The SERS intensity decreased exponentially after the substrate was exposed to the ambient air, which consequently led to an increased standard deviation [ 21 ]. To be improved, the stability, wet chemistry-based methods are used to construct nanoparticles on SERS substrates [ 22 , 23 ]. However, these synthesis processes are usually time-consuming, and the surface morphology of resulting substrates is not reproducible.…”

Section: Introductionmentioning

confidence: 99%

Highly Sensitive, Robust, and Recyclable TiO2/AgNP Substrate for SERS Detection

et al. 2022

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Label-free biosensors provide an important platform for detecting chemical and biological substances without needing extra labeling agents. Unlike surface-based techniques such as surface plasmon resonance (SPR), interference, and ellipsometry, surface-enhanced Raman spectroscopy (SERS) possesses the advantage of monitoring analytes both on surfaces and in solutions. Increasing the SERS enhancement is crucial to preparing high-quality substrates without quickly losing their stability, sensitivity, and repeatability. However, fabrication methods based on wet chemistry, nanoimprint lithography, spark discharge, and laser ablation have drawbacks of waste of time, complicated processes, or nonreproducibility in surface topography. This study reports the preparation of recyclable TiO2/Ag nanoparticle (AgNP) substrates by using simple arc ion plating and direct-current (dc) magnetron sputtering technologies. The deposited anatase-phased TiO2 ensured the photocatalytic degradation of analytes. By measuring the Raman spectra of rhodamine 6G (R6G) in titrated concentrations, a limit of detection (LOD) of 10−8 M and a SERS enhancement factor (EF) of 1.01 × 109 were attained. Self-cleaning was performed via UV irradiation, and recyclability was achieved after at least five cycles of detection and degradation. The proposed TiO2/AgNP substrates have the potential to serve as eco-friendly SERS enhancers for label-free detection of various chemical and biological substances.

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Fast self-assembly of silver nanoparticle monolayer in hydrophobic environment and its application as SERS substrate

Cited by 22 publications

References 31 publications

SERS-Activated Platforms for Immunoassay: Probes, Encoding Methods, and Applications

SERS-Activated Platforms for Immunoassay: Probes, Encoding Methods, and Applications

Hierarchically-Designed 3D Flower-Like Composite Nanostructures as an Ultrastable, Reproducible, and Sensitive SERS Substrate

Highly Sensitive, Robust, and Recyclable TiO2/AgNP Substrate for SERS Detection

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