Fasting before living-kidney donation: effect on donor well-being and postoperative recovery: study protocol of a multicenter randomized controlled trial

Oudmaijer, Christiaan A. J.; Minnee, Robert C.; Pol, Robert A.; Boogaard, W. M. C. van den; Komninos, Daphne S. J.; Wetering, Jacqueline van de; Heugten, Martijn H van; Hoorn, Ewout J.; Sanders, Jan-Stephan; Hoeijmakers, Jan; Vermeij, Wilbert P.; IJzermans, Jan N.M.

doi:10.1186/s13063-021-05950-x

Cited by 9 publications

(10 citation statements)

References 55 publications

(45 reference statements)

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“…This was not as expected, given that on average, women tend to crave sweet treats more than men 37 38. Lastly, study personnel were found to significantly rate lower, influenced by their involvement in the active trials,29–31 possibly setting higher standards for the coordinating investigator or they were just sad to see a familiar batch of brownies distributed to others. The consistent findings in the subscores support the absence of the ‘Brownie-Effect’.…”

Section: Discussionmentioning

confidence: 89%

“…We selected 200 email addresses of healthcare professionals from departments associated with the active clinical trials 29–31. The survey was sent twice, on 26 April 2023 and 10 May 2023, and people were given a response window of 6 weeks from 26 April 2023.…”

Section: Methodsmentioning

confidence: 99%

“…Contents and protocol on this investigational product have been published earlier 6. At the start of the presentation, colleagues were informed about the content of the presentation; an update on the active clinical trials investigating STF 29–31. After this brief introduction, they received information about the current randomised study.…”

Section: Methodsmentioning

confidence: 99%

“…We hypothesise that providing a treat positively influences the score given by participants who are not familiar with fasting, while not or negatively influencing the participants who are familiar with it. By combining two studies we hope to shed light on the factors that shape the attitudes of medical professionals toward research into fasting, to facilitate successful implementation of potential findings of current research,29–31 and ultimately contribute to evidence-based strategies. In summary, our study explores the effect of treats offered as a treat during presentations about IF and STF, while accounting for the irony of the situation: a calorie-rich brownie versus the information on the potential health benefits of restricting calories.…”

Section: Introductionmentioning

confidence: 99%

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Do treats facilitate the interpretation of findings on caloric restriction?

Oudmaijer,

Pol,

Minnee

et al. 2023

BMJNPH

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IntroductionFood can build social bonds and enhance interpersonal relationships. An area of research perhaps at odds with food abundance, is caloric restriction (CR), intermittent fasting (IF) or short-term fasting (STF). We aimed to study the impact of offering treats on the audience during presentations on IF and STF and whether this impacted the audience’s reception of the subject. The contradiction of the tempting nature of sharing brownies juxtaposed with the potential health benefits presented is a light-hearted subject in a world where nutritional intake and health outcomes are the object of intense academic discussion.ObjectiveInvestigate how treats influence hospital personnel interpretation of information presented on the potential benefits of CR, IF and STF.MethodsThis trial consists of a cross-sectional study (CSS) and a randomised controlled trial (RCT) conducted at three study centres. The CSS involved a survey administered to healthcare professionals to assess their knowledge, experience and willingness regarding IF and/or STF. In the RCT, brownies were randomly provided to healthcare staff attending a scientific meeting on restricting calories.Results135 participants were included in the CSS and 64 participants joined the randomised experiment. We found that the randomisation had no statistically significant effect. Only 2 out of 64 were aware of the irony of the provided treatment. In the CSS, participants most often cited the expected beneficial effects on their short-term and long-term health as important reasons for adhering to IF and/or STF. Perceiving fasting as beneficial was mostly influenced by knowledge on the topic and previously adhering to a fasting diet.DiscussionIn this light-hearted, holiday-inspired exploratory study, we found that providing your audience with treats does not influence participants’ opinion of you or your research, even when it focuses on the benefits of reducing calorie intake. The recipients of the treat will remain critical of presented findings, and due to prior experiences will be receptive to the counterintuitive topic of fasting.

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Section: Discussionmentioning

confidence: 89%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Do treats facilitate the interpretation of findings on caloric restriction?

Oudmaijer,

Pol,

Minnee

et al. 2023

BMJNPH

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“…We suggest three main pathomechanisms for symptom reduction in OA through fasting. One is the anti-inflammatory effect of fasting that has been shown in animal and human studies (5,13,34,55). This is probably mediated by cellular stress-response mechanisms such as autophagy, mitophagy and sirtuine-activation, as well as systemic hormonal and metabolic responses to nutrient deprivation (5,56).…”

Section: Discussionmentioning

confidence: 99%

Effects of Prolonged Fasting During Inpatient Multimodal Treatment on Pain and Functional Parameters in Knee and Hip Osteoarthritis: A Prospective Exploratory Observational Study

Koppold¹,

Kandil²,

Güttler³

et al. 2023

Preprint

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Preliminary clinical data suggest pain reduction through fasting in different diagnoses. This uncontrolled observational clinical study examined the effects of prolonged modified fasting on pain and functional parameters in hip and knee osteoarthritis. Patients admitted to the inpatient department of Internal Medicine and Nature-based Therapies of the Immanuel Hospital Berlin between February 2018 and March 2020, answered questionnaires at the beginning and end of inpatient treatment, as well as 3, 6 and 12 months after discharge. Additionally, selected blood and anthropometric parameters were routinely assessed during the inpatient stay. Fasting was performed as part of a multimodal integrative treatment program, with daily caloric intake of <600 kcal for 7.7 ± 1.7 days. N=125 consecutive patients were included. Results revealed an amelioration of overall symptomatology (WOMAC Index score: -14.8±13.31; p<0.001; d=0.78), and pain alleviation (NRS Pain: -2.7±1.98, p<0.001, d=1.48). Pain medication was reduced, stopped, or replaced by herbal remedies in 36% of patients. Improvements were also observed in secondary outcome parameters, including increased quality of life (WHO-5: +4.5±4.94, p<0.001, d=0.94), reduced anxiety (HADS-A: -2.1±2.91, p<0001, d=0.55) and depression (HADS-D: -2.3±3.01, p<0.001, d=0.65), decreases in body weight (-3.6 kg ± 1.65, p< 0.001, d=0.21), and blood pressure (systolic: -6.2±15.93, p<0.001, d= 0.43; diastolic: -3.7±10.55, p<0.001, d=0.43). Results suggest that patients with osteoarthritis of the lower extremities may profit from a prolonged fast embedded in a multimodal integrative treatment regarding quality of life, pain, and disease-specific functional parameters. Confirmatory RCTs are warranted to further investigate these hypotheses.

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